STRINGSTRING
PTF1A PTF1A NANOS1 NANOS1 HSPA5 HSPA5 NAGLU NAGLU CEND1 CEND1 CDK5R1 CDK5R1 SMO SMO SEC24B SEC24B KLHL5 KLHL5 ENSGALP00000051793 ENSGALP00000051793 GBX2 GBX2 EN1 EN1 ABL2 ABL2 SEZ6L SEZ6L UQCRQ UQCRQ DIXDC1 DIXDC1 PDSS2 PDSS2 DLL1 DLL1 TRNP1 TRNP1 ENSGALP00000068651 ENSGALP00000068651 CDK5 CDK5 KLHL1 KLHL1 RPGRIP1L RPGRIP1L MECP2 MECP2 ENSGALP00000070978 ENSGALP00000070978 WHRN WHRN ZNF365 ZNF365 OTX1 OTX1 SEZ6 SEZ6 TTBK2-2 TTBK2-2 TTLL1 TTLL1 PTBP2 PTBP2 AARS AARS KIF14 KIF14 ABL1 ABL1 SERPINE2 SERPINE2 LHX1 LHX1 CRKL CRKL KLHL4 KLHL4 KNDC1 KNDC1 CLP1 CLP1 LHX5 LHX5 NEUROD1 NEUROD1 NCSTN NCSTN TTBK2 TTBK2 GNPAT GNPAT AGTPBP1 AGTPBP1 BCL2 BCL2 LRRC1 LRRC1 FZD4 FZD4 TTC21B TTC21B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTF1APancreas associated transcription factor 1a. (275 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (254 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (751 aa)
CEND1Uncharacterized protein. (130 aa)
CDK5R1Cyclin dependent kinase 5 regulatory subunit 1. (300 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
SEC24BUncharacterized protein. (1234 aa)
KLHL5Kelch like family member 5. (508 aa)
ENSGALP00000051793Uncharacterized protein. (360 aa)
GBX2Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa)
EN1Homeobox protein engrailed-1. (334 aa)
ABL2Tyrosine-protein kinase. (1159 aa)
SEZ6LSeizure related 6 homolog like. (988 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
DIXDC1DIX domain containing 1. (689 aa)
PDSS2Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (394 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
TRNP1Uncharacterized protein. (622 aa)
ENSGALP00000068651Uncharacterized protein. (150 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
KLHL1Kelch like family member 1. (776 aa)
RPGRIP1LRPGRIP1 like. (1273 aa)
MECP2Methyl-CpG binding protein 2. (208 aa)
ENSGALP00000070978XRCC1_N domain-containing protein. (182 aa)
WHRNWhirlin. (926 aa)
ZNF365Uncharacterized protein. (403 aa)
OTX1Orthodenticle homeobox 1. (335 aa)
SEZ6Seizure related 6 homolog. (823 aa)
TTBK2-2Uncharacterized protein. (577 aa)
TTLL1Tubulin tyrosine ligase like 1. (443 aa)
PTBP2Polypyrimidine tract binding protein 2. (675 aa)
AARSAA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (968 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa)
ABL1Tyrosine-protein kinase. (1111 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (442 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
CRKLCRK like proto-oncogene, adaptor protein. (193 aa)
KLHL4Kelch like family member 4. (720 aa)
KNDC1Uncharacterized protein. (1900 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phospho [...] (425 aa)
LHX5LIM homeobox protein 5. (402 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
TTBK2Tau tubulin kinase 2. (435 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (876 aa)
AGTPBP1Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1225 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
FZD4Frizzled-4; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 ki [...] (525 aa)
TTC21BTetratricopeptide repeat domain 21B. (1411 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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