STRINGSTRING
ELF3 ELF3 MED1 MED1 MST1 MST1 CUL3 CUL3 CEBPB CEBPB RXFP1 RXFP1 FRS2 FRS2 AREG AREG BCL2 BCL2 LRRC1 LRRC1 EDAR EDAR TGFB2 TGFB2 FGF8 FGF8 LAMA1 LAMA1 TGFB3 TGFB3 IGFBP5 IGFBP5 SOX9 SOX9 TGFA TGFA FGF7 FGF7 ENSGALP00000044025 ENSGALP00000044025 MSN MSN CYP7B1 CYP7B1 AR AR BTRC BTRC NKX2-3 NKX2-3 NKX2-6 NKX2-6 HOXB13 HOXB13 LOC101750972 LOC101750972 DAG1 DAG1 EDA EDA HOXD13 HOXD13 ESRP2 ESRP2 EPHA2 EPHA2 POLB POLB TP63 TP63 PMLL PMLL CSF1 CSF1 GDF7 GDF7 SEMA3C SEMA3C PLAG1 PLAG1 IL6 IL6 PLXND1 PLXND1 ENSGALP00000068651 ENSGALP00000068651 FGL1 FGL1 LOC112530162 LOC112530162
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELF3E74 like ETS transcription factor 3. (371 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
MST1Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (704 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
CEBPBCCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...] (328 aa)
RXFP1Relaxin family peptide receptor 1. (763 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
AREGAmphiregulin. (210 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
EDAREctodysplasin A1 receptor. (448 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
LAMA1Uncharacterized protein. (3091 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
TGFAEGF-like domain-containing protein. (156 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
MSNMoesin. (580 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (487 aa)
ARUncharacterized protein. (703 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (793 aa)
NKX2-3Homeobox domain-containing protein. (328 aa)
NKX2-6Homeobox domain-containing protein. (193 aa)
HOXB13Homeobox B13. (265 aa)
LOC101750972Peptidase S72 domain-containing protein. (1177 aa)
DAG1Peptidase S72 domain-containing protein. (896 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (364 aa)
HOXD13Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription (By similarity). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (303 aa)
ESRP2Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity); Belongs to the ESRP family. (728 aa)
EPHA2EPH receptor A2. (1288 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (181 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PMLLUncharacterized protein. (464 aa)
CSF1Uncharacterized protein. (493 aa)
GDF7Growth differentiation factor 7. (400 aa)
SEMA3CSemaphorin-3C; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (751 aa)
PLAG1Zinc finger protein PLAG1; Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. (501 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
PLXND1Plexin D1. (1928 aa)
ENSGALP00000068651Uncharacterized protein. (150 aa)
FGL1Fibrinogen C-terminal domain-containing protein. (313 aa)
LOC112530162Uncharacterized protein. (159 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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