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| | CHERP | Uncharacterized protein. (1018 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa) |
| | TRPC1 | Transient receptor potential cation channel subfamily C member 1 isoform alpha; Belongs to the transient receptor (TC 1.A.4) family. (781 aa) |
| | KCTD7 | BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons. (289 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | NCOA4 | Uncharacterized protein. (601 aa) |
| | STOML2 | Stomatin like 2. (382 aa) |
| | NPTN | Uncharacterized protein. (397 aa) |
| | ATP2A3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. (1042 aa) |
| | CLIC4 | Chloride intracellular channel 4. (253 aa) |
| | HERPUD1 | Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa) |
| | EDN2 | Endothelin-2. (179 aa) |
| | CCDC47 | Coiled-coil domain containing 47. (481 aa) |
| | LCK | Proto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa) |
| | STC1 | Stanniocalcin 1. (247 aa) |
| | TMEM9 | Transmembrane protein 9A. (191 aa) |
| | SLC9A8 | Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity); Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (645 aa) |
| | IMMT | MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (743 aa) |
| | SLC11A2 | Uncharacterized protein. (1307 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa) |
| | ENSGALP00000069823 | Uncharacterized protein. (167 aa) |
| | SLC39A13 | Zinc transporter ZIP13; Acts as a zinc-influx transporter. (485 aa) |
| | STEAP4 | STEAP4 metalloreductase. (472 aa) |
| | ATP6V1A | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. (617 aa) |
| | HJV | Hemojuvelin BMP co-receptor. (514 aa) |
| | SLC4A2 | Anion exchange protein. (1411 aa) |
| | ENSGALP00000071132 | Uncharacterized protein. (386 aa) |
| | LACC1 | Uncharacterized protein. (438 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa) |
| | SLC39A12 | Solute carrier family 39 member 12. (702 aa) |
| | MICU1 | Mitochondrial calcium uptake 1. (502 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa) |
| | ENSGALP00000072166 | IPT/TIG domain-containing protein. (239 aa) |
| | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known; Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa) |
| | HPS1 | Uncharacterized protein. (788 aa) |
| | KEL | Uncharacterized protein. (720 aa) |
| | TMTC4 | Transmembrane O-mannosyltransferase targeting cadherins 4. (826 aa) |
| | ENSGALP00000072903 | Uncharacterized protein. (81 aa) |
| | SLC4A7 | Anion exchange protein. (1243 aa) |
| | ATP13A5 | Uncharacterized protein. (253 aa) |
| | MICU2 | Mitochondrial calcium uptake 2. (506 aa) |
| | ENSGALP00000073501 | Uncharacterized protein. (458 aa) |
| | RNASEK | Ribonuclease K. (130 aa) |
| | SCO1 | SCO cytochrome c oxidase assembly protein 1. (558 aa) |
| | SLC1A3 | Amino acid transporter. (543 aa) |
| | ENSGALP00000074194 | Uncharacterized protein. (401 aa) |
| | CLN6 | Uncharacterized protein. (317 aa) |
| | TRPC5 | Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (969 aa) |
| | ATP7A | ATPase copper transporting alpha. (1494 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa) |
| | ATP2B2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1274 aa) |
| | LOC112530475 | B30.2/SPRY domain-containing protein. (311 aa) |
| | LOC101750621 | Uncharacterized protein. (332 aa) |
| | SCNN1D | Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa) |
| | TRPC6 | Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (951 aa) |
| | ENSGALP00000066589 | Uncharacterized protein. (349 aa) |
| | SLC10A7 | Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (355 aa) |
| | ISCU | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (158 aa) |
| | FRRS1 | Ferric chelate reductase 1. (593 aa) |
| | ENSGALP00000067557 | Uncharacterized protein. (239 aa) |
| | ENSGALP00000067603 | Uncharacterized protein. (698 aa) |
| | DMXL1 | Dmx like 1. (3057 aa) |
| | PKHD1 | Uncharacterized protein. (551 aa) |
| | ENSGALP00000067896 | Uncharacterized protein. (105 aa) |
| | SCO2 | SCO cytochrome c oxidase assembly protein 2. (251 aa) |
| | RGN | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). (299 aa) |
| | SLC39A6 | Solute carrier family 39 member 6. (720 aa) |
| | PACS2 | Phosphofurin acidic cluster sorting protein 2. (917 aa) |
| | LOC107049680 | ATP-synt_ab domain-containing protein. (721 aa) |
| | SLC9A5 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (909 aa) |
| | ABCB7 | ATP binding cassette subfamily B member 7. (684 aa) |
| | SLC39A10 | Solute carrier family 39 member 10. (719 aa) |
| | F2 | Uncharacterized protein; Belongs to the peptidase S1 family. (644 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) |
| | SLC24A3 | Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (595 aa) |
| | SLC8A1 | Sodium calcium exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (969 aa) |
| | ATP6AP1 | Uncharacterized protein. (455 aa) |
| | STEAP2 | STEAP2 metalloreductase. (489 aa) |
| | ANKRD9L | ANK_REP_REGION domain-containing protein. (293 aa) |
| | SLC8A3 | Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa) |
| | SLC30A1 | Solute carrier family 30 member 1. (516 aa) |
| | EDNRA | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa) |
| | GLRX3 | Uncharacterized protein. (328 aa) |
| | RMDN2 | Uncharacterized protein. (427 aa) |
| | SLC24A4 | Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (528 aa) |
| | SLC4A3 | Anion exchange protein. (1249 aa) |
| | SLC11A1 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (555 aa) |
| | TRPC3 | ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (933 aa) |
| | SMDT1 | Single-pass membrane protein with aspartate rich tail 1. (94 aa) |
| | MCUB | Mitochondrial calcium uniporter dominant negative beta subunit. (406 aa) |
| | GRM1 | Glutamate metabotropic receptor 1. (1152 aa) |
| | SLC39A8 | Solute carrier family 39 member 8. (493 aa) |
| | MCUR1 | Mitochondrial calcium uniporter regulator 1. (273 aa) |
| | EDN1 | Endothelin 1. (194 aa) |
| | GCM2 | GCM domain-containing protein. (471 aa) |
| | BMP6 | Bone morphogenetic protein 6. (434 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | SCGN | Secretagogin, EF-hand calcium binding protein. (273 aa) |
| | STIM2 | Stromal interaction molecule 2. (740 aa) |
| | MT3 | Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (63 aa) |
| | HEXB | Beta-hexosaminidase. (558 aa) |
| | DRD3 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (425 aa) |
| | CHRNA8 | Alpha8 subunit of nicotinic acetylcholine receptor. (511 aa) |
| | TMEM175 | Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel; Belongs to the TMEM175 family. (501 aa) |
| | GPR89A | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. (455 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (874 aa) |
| | ATP6AP1L | ATPase H+ transporting accessory protein 1 like. (356 aa) |
| | LETM1 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). (755 aa) |
| | TMPRSS3 | Transmembrane serine protease 3; Belongs to the peptidase S1 family. (470 aa) |
| | RGNL | SGL domain-containing protein. (302 aa) |
| | ATP4B | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa) |
| | RAB20 | RAB20, member RAS oncogene family. (163 aa) |
| | HTR2A | 5-hydroxytryptamine (Serotonin) receptor 2A. (468 aa) |
| | ATP7B | ATPase copper transporting beta. (1530 aa) |
| | RAB39A | RAB39A, member RAS oncogene family. (216 aa) |
| | TRPC7 | Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (853 aa) |
| | GRM5 | G_PROTEIN_RECEP_F3_4 domain-containing protein. (1242 aa) |
| | TRPC4 | Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (974 aa) |
| | SLC26A3 | Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (754 aa) |
| | TRPC2L | XRCC1_N domain-containing protein. (375 aa) |
| | HCRTR2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (501 aa) |
| | CHP1 | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa) |
| | SLC30A7 | Zinc transporter 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis (By similarity). Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP. (378 aa) |
| | ATP6AP2 | Uncharacterized protein. (354 aa) |
| | APP | BPTI/Kunitz inhibitor domain-containing protein. (751 aa) |
| | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (305 aa) |
| | CASQ2 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (406 aa) |
| | ATF4 | ATF4. (354 aa) |
| | FXN | Frataxin. (167 aa) |
| | SLC24A5 | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (423 aa) |
| | CD40 | Uncharacterized protein. (299 aa) |
| | TMEM203 | Transmembrane protein 203. (136 aa) |
| | SLC9A9 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (642 aa) |
| | STC2 | Stanniocalcin 2. (306 aa) |
| | SLC30A10 | Solute carrier family 30 member 10. (232 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa) |
| | FTL | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (278 aa) |
| | CALB2 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa) |
| | ANKRD9 | Ankyrin repeat domain 9. (292 aa) |
| | MT4 | Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals; Belongs to the metallothionein superfamily. Type 1 family. (63 aa) |
| | PLN | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). (52 aa) |
| | SLC26A6 | STAS domain-containing protein. (752 aa) |
| | COX19 | CHCH domain-containing protein. (93 aa) |
| | CAV1 | Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa) |
| | MAIP1 | Matrix AAA peptidase interacting protein 1. (248 aa) |
| | LETM2 | Leucine zipper and EF-hand containing transmembrane protein 2. (324 aa) |
| | SLC30A9 | Solute carrier family 30 member 9. (645 aa) |
| | PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa) |
| | STIM1 | SAM domain-containing protein. (742 aa) |
| | ASPH-2 | Asp-B-Hydro_N domain-containing protein. (350 aa) |
| | CHTOP | Mothers against decapentaplegic homolog. (445 aa) |
| | SLC4A4 | Anion exchange protein. (1113 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6 (Langereis blood group). (894 aa) |
| | SLC4A10 | Anion exchange protein. (1116 aa) |
| | SLC30A8 | Solute carrier family 30 member 8. (384 aa) |
| | SLC9A7 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa) |
| | SLC4A1 | Band 3 anion transport protein; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride- bicarbonate exch [...] (923 aa) |
| | SLC9A3 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (830 aa) |
| | SLC40A1 | Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (581 aa) |
| | CYB561A3 | Cytochrome b561 domain-containing protein. (272 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (825 aa) |
| | ATP13A1 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1254 aa) |
| | SLC31A2 | Solute carrier family 31 member 2. (239 aa) |
| | LOC100859230 | Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (892 aa) |
| | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (863 aa) |
| | HEPH | Hephaestin; Belongs to the multicopper oxidase family. (1167 aa) |
| | PKD2 | Uncharacterized protein. (881 aa) |
| | DISC1 | DISC1 scaffold protein. (856 aa) |
| | SLC39A14 | Solute carrier family 39 member 14. (508 aa) |
| | ANXA2P2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa) |
| | MCU | Mitochondrial calcium uniporter. (344 aa) |
| | CA7 | Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (259 aa) |
| | RYR2 | Ryanodine receptor 2. (4957 aa) |
| | CYBRD1 | Cytochrome b reductase 1. (289 aa) |
| | SLC4A8 | Anion exchange protein. (1068 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa) |
| | RYR3 | Uncharacterized protein. (4862 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (842 aa) |
| | DHRS7C | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa) |
| | MICU3 | Mitochondrial calcium uptake family member 3. (511 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | SLC4A5 | Anion exchange protein. (1060 aa) |
| | LRRK2 | Uncharacterized protein. (2557 aa) |
| | AQP11 | Aquaporin 11; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa) |
| | GRIA1 | Uncharacterized protein. (902 aa) |
| | TMEM64 | Transmembrane protein 64. (573 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1180 aa) |
| | TRPA1 | ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1126 aa) |
| | RMDN3 | Regulator of microtubule dynamics 3. (459 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa) |
| | ATP2C1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (965 aa) |
| | GRN | Uncharacterized protein. (287 aa) |
| | ATP6V1B2 | V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (503 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa) |
| | IREB2 | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA; Belongs to the aconitase/IPM isomerase family. (965 aa) |
| | ACO1 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). (916 aa) |
| | BAK1 | Uncharacterized protein. (216 aa) |
| | SYPL2 | Synaptophysin like 2. (425 aa) |
| | SCNN1G | Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa) |
| | CALB1 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa) |
| | CA2 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. (260 aa) |
| | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. (1021 aa) |
| | EDN3 | Endothelin 3. (151 aa) |
| | LOC776719 | Uncharacterized protein. (671 aa) |
| | TMEM106B | Uncharacterized protein. (278 aa) |
| | HEPHL1 | Hephaestin like 1; Belongs to the multicopper oxidase family. (1152 aa) |
| | SLC30A5 | Zinc transporter 5; Functions as a zinc transporter. Partly regulates cellular zinc homeostasis. Required with ZNT7 for activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (770 aa) |
| | ATP2B1 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. (1247 aa) |
| | ANXA6 | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity). (782 aa) |
| | SLC31A1 | Uncharacterized protein. (214 aa) |
| | SLC4A11 | Solute carrier family 4 member 11. (867 aa) |
| | NDFIP1 | Nedd4 family interacting protein 1. (213 aa) |
| | SLC35G1 | Solute carrier family 35 member G1. (376 aa) |
| | SLC8A2 | Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (916 aa) |
| | TMCO1 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling. (188 aa) |
| | SLC4A9 | Anion exchange protein. (929 aa) |
| | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. May act as a regulator of TNFSF11-mediated Ca(2+) signaling during osteoclastogenesis. (1042 aa) |
| | VPS33A | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa) |
| | ENSGALP00000060705 | Reelin domain-containing protein. (359 aa) |
| | SLC24A2 | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (651 aa) |
| | CXorf21 | Chromosome X open reading frame 21. (289 aa) |
| | LOC100858381 | Uncharacterized protein. (141 aa) |
| | TMEM165 | GDT1 family protein. (322 aa) |
| | RAB7A | RAB7A, member RAS oncogene family. (207 aa) |
| | PMLL | Uncharacterized protein. (464 aa) |
| | SLC37A4 | Solute carrier family 37 member 4. (451 aa) |
| | HTR2B | Serotonin receptor subtype 2b. (462 aa) |
| | TPCN2 | Uncharacterized protein. (753 aa) |
| | VAPB | MSP domain-containing protein. (243 aa) |
| | SLC24A1 | Sodium/potassium/calcium exchanger 1; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). (663 aa) |
| | TFRC | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa) |
| | NUBP1 | Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (323 aa) |
| | FTH1 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). (180 aa) |
| | ATP6V1G1 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | ATP13A4 | Probable cation-transporting ATPase 13A4; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1205 aa) |
| | TM9SF4 | Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (668 aa) |
| | ATP12A | Sodium/potassium-transporting ATPase subunit alpha. (1033 aa) |
| | TF | Ovotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa) |
| | SCNN1B | Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa) |
| | SLC9A6 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (866 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa) |
| | SELENOK | Uncharacterized protein. (92 aa) |
| | C11H19orf12 | Uncharacterized protein. (306 aa) |
| | CHRNA7 | Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub- subfamily. (502 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | CSRP3 | Uncharacterized protein. (194 aa) |
| | PPT1 | Uncharacterized protein. (300 aa) |
