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EHD3 EHD3 RAB10L RAB10L K4LB56_CHICK K4LB56_CHICK TIRAP TIRAP SYT11 SYT11 RABEP1 RABEP1 STAM2 STAM2 RAB5B RAB5B STX7 STX7 SYT7 SYT7 LPAR2 LPAR2 NOD1 NOD1 RAPGEF6 RAPGEF6 RAB2B RAB2B DPP4 DPP4 LAMP1 LAMP1 UVRAG UVRAG STX8 STX8 RAPGEF2 RAPGEF2 TMEM55A TMEM55A UNC93B1 UNC93B1 IGF2R IGF2R CLTCL1 CLTCL1 LMBRD1 LMBRD1 RAB23 RAB23 SLC18A3 SLC18A3 AP2A2 AP2A2 APPL2 APPL2 RAB38 RAB38 FFAR4 FFAR4 ARF6 ARF6 OCRL OCRL VPS9D1 VPS9D1 CDC42EP4 CDC42EP4 AMBRA1 AMBRA1 TYRP1 TYRP1 OVAL OVAL RAB10 RAB10 CD2AP CD2AP VAMP3 VAMP3 RAB7B RAB7B RAB31 RAB31 VAMP7 VAMP7 RAB39A RAB39A RAB20 RAB20 RAB9A RAB9A SH3KBP1 SH3KBP1 MYO6 MYO6 LPAR1 LPAR1 ECPAS ECPAS TRIM14 TRIM14 SYK SYK PLA2G5 PLA2G5 RAB32 RAB32 ATG14 ATG14 SCARB2 SCARB2 SLC11A1 SLC11A1 AMN AMN RAB5A RAB5A SGIP1 SGIP1 HEATR5B HEATR5B INPP5F INPP5F STXBP3 STXBP3 CDC42 CDC42 GAPVD1 GAPVD1 AP2S1 AP2S1 INPP5B INPP5B ENSGALP00000066581 ENSGALP00000066581 HEATR5A HEATR5A STXBP4 STXBP4 ANXA11 ANXA11 TLR15 TLR15 SLC11A2 SLC11A2 RAB11FIP3 RAB11FIP3 VPS11 VPS11 RAB11FIP1 RAB11FIP1 RAB11FIP4 RAB11FIP4 RIN3 RIN3 PIK3C3 PIK3C3 ENSGALP00000073042 ENSGALP00000073042 EHD2 EHD2 RAB7A RAB7A RAB11B RAB11B STX12 STX12 RAB14 RAB14 VPS26B VPS26B RILP RILP MTOR MTOR RAB5C RAB5C STX10 STX10 RAB17 RAB17 RAB9B RAB9B CLTC CLTC APPL1 APPL1 APOA1 APOA1 RAB35 RAB35 RAB22A RAB22A RAB11A RAB11A AP2M1 AP2M1 RIN2 RIN2 CTLA4 CTLA4 PIKFYVE PIKFYVE EHD4 EHD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHD3Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
RAB10LUncharacterized protein. (208 aa)
K4LB56_CHICKCD150. (333 aa)
TIRAPTIR domain-containing protein. (231 aa)
SYT11Synaptotagmin 11. (432 aa)
RABEP1Uncharacterized protein. (782 aa)
STAM2Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). (576 aa)
RAB5BRas-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
STX7t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa)
SYT7Synaptotagmin 7. (403 aa)
LPAR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
NOD1Uncharacterized protein. (951 aa)
RAPGEF6Uncharacterized protein. (1585 aa)
RAB2BUncharacterized protein. (428 aa)
DPP4Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa)
UVRAGC2 domain-containing protein. (707 aa)
STX8t-SNARE coiled-coil homology domain-containing protein. (273 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1652 aa)
TMEM55APhosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (571 aa)
IGF2RFibronectin type-II domain-containing protein. (2561 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
LMBRD1Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity); Belongs to the LIMR family. LMBRD1 subfamily. (539 aa)
RAB23Uncharacterized protein. (237 aa)
SLC18A3MFS domain-containing protein. (522 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (965 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
RAB38RAB38, member RAS oncogene family. (212 aa)
FFAR4Free fatty acid receptor 4. (349 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa)
OCRLRho-GAP domain-containing protein. (1013 aa)
VPS9D1VPS9 domain containing 1. (501 aa)
CDC42EP4CDC42 effector protein 4. (302 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
CD2APUncharacterized protein. (640 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
VAMP7Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family. (220 aa)
RAB39ARAB39A, member RAS oncogene family. (216 aa)
RAB20RAB20, member RAS oncogene family. (163 aa)
RAB9AUncharacterized protein. (201 aa)
SH3KBP1Uncharacterized protein. (739 aa)
MYO6Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-su [...] (1276 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ECPASEcm29 proteasome adaptor and scaffold. (1872 aa)
TRIM14Uncharacterized protein. (433 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
PLA2G5Phospholipase A(2). (158 aa)
RAB32Uncharacterized protein. (218 aa)
ATG14Autophagy related 14. (492 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (481 aa)
SLC11A1Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (555 aa)
AMNUncharacterized protein. (477 aa)
RAB5AUncharacterized protein. (215 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1. (783 aa)
HEATR5BHEAT repeat containing 5B. (2073 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1126 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
GAPVD1Uncharacterized protein. (1488 aa)
AP2S1Adaptor related protein complex 2 subunit sigma 1. (279 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (942 aa)
ENSGALP00000066581Uncharacterized protein. (532 aa)
HEATR5AHEAT repeat containing 5A. (2031 aa)
STXBP4Syntaxin binding protein 4. (736 aa)
ANXA11Annexin. (496 aa)
TLR15TIR domain-containing protein. (924 aa)
SLC11A2Uncharacterized protein. (1307 aa)
RAB11FIP3RAB11 family interacting protein 3. (689 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (957 aa)
RAB11FIP1RAB11 family interacting protein 1. (1259 aa)
RAB11FIP4RAB11 family interacting protein 4. (496 aa)
RIN3Ras and Rab interactor 3. (983 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
ENSGALP00000073042Rho-GAP domain-containing protein. (180 aa)
EHD2EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
RAB11BUncharacterized protein. (218 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (272 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
VPS26BVPS26, retromer complex component B. (336 aa)
RILPRab interacting lysosomal protein. (400 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
RAB5CRas-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity). (216 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
RAB17RAB17, member RAS oncogene family. (213 aa)
RAB9BRAB9B, member RAS oncogene family. (261 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (806 aa)
APOA1Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa)
RAB35Uncharacterized protein. (201 aa)
RAB22AUncharacterized protein. (194 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). (216 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide- containing lipids (By similarity). (489 aa)
RIN2Ras and Rab interactor 2. (664 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (205 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (542 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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