STRINGSTRING
CAPN1 CAPN1 CEP131 CEP131 SPATA1 SPATA1 SLC18A2 SLC18A2 CAPN8 CAPN8 CALCR CALCR THBS1 THBS1 SCG5 SCG5 GTPBP2 GTPBP2 TMED10 TMED10 MMRN1 MMRN1 TRIP11 TRIP11 MEPE MEPE NPY NPY SNX10 SNX10 PLAC8 PLAC8 CTSV CTSV SPX SPX ZPBP2 ZPBP2 ITPR2 ITPR2 AVP AVP PCSK1 PCSK1 HEXB HEXB S100Z S100Z CRHBP CRHBP PLA1A PLA1A DENND4C DENND4C PAM PAM PENK PENK WFS1 WFS1 OLFM4 OLFM4 RCBTB2 RCBTB2 BRCA2 BRCA2 TSTD1 TSTD1 PLA2G10L PLA2G10L DEFB4A DEFB4A PLA2G10 PLA2G10 VAMP3 VAMP3 AvBD1 AvBD1 RAB10 RAB10 ZPBP ZPBP OXT OXT CYB561 CYB561 NUDT1 NUDT1 SNAPIN SNAPIN SLC17A9 SLC17A9 BMF BMF SYT1 SYT1 GAL GAL STBD1 STBD1 SYPL1 SYPL1 CAV1 CAV1 RAB37 RAB37 SCG2 SCG2 SPAG17 SPAG17 SCG3 SCG3 RAB12 RAB12 SLC30A8 SLC30A8 SCFD2 SCFD2 RAB26 RAB26 LOC425940 LOC425940 BAIAP2 BAIAP2 MYRIP MYRIP TCIRG1 TCIRG1 ASTL ASTL SCNN1A SCNN1A ICA1 ICA1 DLD DLD PTPRN2 PTPRN2 SYT2 SYT2 DBH DBH ACPP ACPP F5 F5 STXBP5L STXBP5L SEC11A SEC11A PTPRN PTPRN MYO5A MYO5A SPATA16 SPATA16 SYT4 SYT4 ECRG4 ECRG4 SYTL4 SYTL4 ENSGALP00000051312 ENSGALP00000051312 CTSH CTSH CAPN11 CAPN11 STXBP1 STXBP1 VPS13A VPS13A MYO5C MYO5C MYH9 MYH9 LOC100859819 LOC100859819 CFAP65 CFAP65 SEC11C SEC11C TBXA2R TBXA2R CARTPT CARTPT LRGUK LRGUK GMFB GMFB SYT7 SYT7 SPACA9 SPACA9 LOC776719 LOC776719 C1orf35 C1orf35 ENSGALP00000058230 ENSGALP00000058230 KNL1 KNL1 UVS.2L UVS.2L SPACA1 SPACA1 HEXA HEXA SCAMP1 SCAMP1 DNASE1 DNASE1 IFT20 IFT20 POMC POMC GARS GARS CAV2 CAV2 VPS33B VPS33B CHGB CHGB DNASE1L2 DNASE1L2 EBAG9 EBAG9 STXBP3 STXBP3 CCDC189 CCDC189 SFTPC SFTPC SCNN1D SCNN1D STK31 STK31 ABHD2 ABHD2 ENSGALP00000066467 ENSGALP00000066467 RAB27A RAB27A HYAL6 HYAL6 HYAL3 HYAL3 STXBP5 STXBP5 ANXA11 ANXA11 TSSK3 TSSK3 ENSGALP00000068902 ENSGALP00000068902 CAPN14 CAPN14 VPS13C VPS13C SYCN SYCN KIAA1210 KIAA1210 GRP GRP TMED2 TMED2 ATP6V1A ATP6V1A PHACTR2 PHACTR2 RAB2A RAB2A ENSGALP00000071604 ENSGALP00000071604 IQUB IQUB ITPR1 ITPR1 VPS13B VPS13B RAB4A RAB4A CBARP CBARP GH GH HYAL1 HYAL1 BSG BSG TEKT3 TEKT3 MOXD1 MOXD1 ATP6V0A2 ATP6V0A2 PLAT PLAT POMT1 POMT1 TMEM184A TMEM184A OPNP OPNP SERPINE2 SERPINE2 GHRHR GHRHR SYT9 SYT9 HPS4 HPS4 SYT8 SYT8 TMPRSS4 TMPRSS4 ENKUR ENKUR SPAG6 SPAG6 HSPD1 HSPD1 CAV3 CAV3 TRH TRH E1BU02_CHICK E1BU02_CHICK SNAP23 SNAP23 FGG FGG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (715 aa)
CEP131Centrosomal protein 131. (1161 aa)
SPATA1SPATA1_C domain-containing protein. (163 aa)
SLC18A2Solute carrier family 18 member A2. (633 aa)
CAPN8Calpain 8; Belongs to the peptidase C2 family. (702 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (469 aa)
THBS1Uncharacterized protein. (1175 aa)
SCG5Uncharacterized protein. (208 aa)
GTPBP2GTP binding protein 2. (605 aa)
TMED10GOLD domain-containing protein. (219 aa)
MMRN1Multimerin 1. (1192 aa)
TRIP11Thyroid hormone receptor interactor 11. (1980 aa)
MEPEOvocleidin-116; Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones. (743 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
SNX10PX domain-containing protein. (201 aa)
PLAC8Uncharacterized protein. (145 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
SPXSpexin hormone. (116 aa)
ZPBP2Zona pellucida-binding protein 2; May be implicated in the gamete interaction during fertilization; Belongs to the zona pellucida-binding protein Sp38 family. (352 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
AVPVasotocin-neurophysin VT; Vasotocin is an antidiuretic hormone. (161 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
HEXBBeta-hexosaminidase. (558 aa)
S100ZProtein S100; Belongs to the S-100 family. (98 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
PLA1APhospholipase A1 member A. (456 aa)
DENND4CDENN domain containing 4C. (1950 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (970 aa)
PENKProenkephalin. (267 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
OLFM4Olfactomedin-like domain-containing protein. (489 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (570 aa)
BRCA2Tower domain-containing protein. (3397 aa)
TSTD1Uncharacterized protein. (358 aa)
PLA2G10LPhospholipase A(2). (158 aa)
DEFB4AGallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. (64 aa)
PLA2G10Phospholipase A(2). (155 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
AvBD1Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. (65 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
ZPBPZona pellucida-binding protein 1; Plays a role in sperm morphogenesis and in sperm-oocyte interaction during fertilization; Belongs to the zona pellucida-binding protein Sp38 family. (344 aa)
OXTMesotocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (124 aa)
CYB561Cytochrome b561. (252 aa)
NUDT1Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (156 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
SLC17A9MFS domain-containing protein. (606 aa)
BMFUncharacterized protein. (200 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family. (430 aa)
GALGalanin variant 1. (141 aa)
STBD1Starch binding domain 1. (290 aa)
SYPL1MARVEL domain-containing protein. (236 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
RAB37RAB37, member RAS oncogene family. (371 aa)
SCG2Secretogranin II. (629 aa)
SPAG17Sperm associated antigen 17. (1778 aa)
SCG3Uncharacterized protein. (469 aa)
RAB12RAB12, member RAS oncogene family. (290 aa)
SLC30A8Solute carrier family 30 member 8. (384 aa)
SCFD2Sec1 family domain containing 2; Belongs to the STXBP/unc-18/SEC1 family. (652 aa)
RAB26RAB26, member RAS oncogene family. (190 aa)
LOC425940Uncharacterized protein. (1491 aa)
BAIAP2BAI1 associated protein 2. (573 aa)
MYRIPRab_eff_C domain-containing protein. (666 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (825 aa)
ASTLAstacin-like metalloendopeptidase; Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. May act as a protease (By similarity). (409 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. (612 aa)
ICA1Islet cell autoantigen 1. (676 aa)
DLDDihydrolipoyl dehydrogenase. (508 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (1030 aa)
SYT2Synaptotagmin 2. (490 aa)
DBHDopamine beta-hydroxylase. (584 aa)
ACPPAcid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (390 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2025 aa)
STXBP5LSyntaxin binding protein 5 like. (1184 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (946 aa)
MYO5AUnconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity). (1830 aa)
SPATA16Spermatogenesis associated 16. (531 aa)
SYT4Synaptotagmin 4. (425 aa)
ECRG4ECRG4 augurin precursor. (112 aa)
SYTL4Synaptotagmin like 4. (690 aa)
ENSGALP00000051312Uncharacterized protein. (411 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
CAPN11Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. (705 aa)
STXBP1Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxins, components of the synaptic vesicle fusion machinery. May play a role in determining the specificity of intracellular fusion reactions (By similarity). Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
VPS13AUncharacterized protein. (3193 aa)
MYO5CMyosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1737 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
LOC100859819CARTL. (113 aa)
CFAP65Cilia- and flagella-associated protein 65; May play a role in sperm motility. (1775 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (177 aa)
TBXA2RThromboxane A2 receptor. (361 aa)
CARTPTCART prepropeptide. (111 aa)
LRGUKLeucine rich repeats and guanylate kinase domain containing. (740 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (141 aa)
SYT7Synaptotagmin 7. (403 aa)
SPACA9Uncharacterized protein. (167 aa)
LOC776719Uncharacterized protein. (671 aa)
C1orf35Chromosome 1 open reading frame 35. (310 aa)
ENSGALP00000058230Uncharacterized protein. (317 aa)
KNL1Knl1_RWD_C domain-containing protein. (399 aa)
UVS.2LMetalloendopeptidase. (281 aa)
SPACA1Sperm acrosome associated 1. (197 aa)
HEXABeta-hexosaminidase. (631 aa)
SCAMP1Secretory carrier-associated membrane protein. (481 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (By similarity). Binds specifically to G-actin and blocks actin polymerization (By similarity). (282 aa)
IFT20Intraflagellar transport 20. (132 aa)
POMCUncharacterized protein. (251 aa)
GARSUncharacterized protein. (859 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
VPS33BUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (667 aa)
CHGBChromogranin B. (673 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
EBAG9Uncharacterized protein. (336 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
CCDC189Uncharacterized protein. (255 aa)
SFTPCBRICHOS domain-containing protein. (202 aa)
SCNN1DSodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
STK31Serine/threonine kinase 31. (1007 aa)
ABHD2Abhydrolase domain containing 2. (425 aa)
ENSGALP00000066467Uncharacterized protein. (248 aa)
RAB27ARab27a. (221 aa)
HYAL6Hyaluronidase. (579 aa)
HYAL3Hyaluronidase. (584 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
ANXA11Annexin. (496 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
ENSGALP00000068902Chorein_N domain-containing protein. (141 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (694 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3587 aa)
SYCNSyncollin. (131 aa)
KIAA1210DUF4592 domain-containing protein. (971 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
TMED2GOLD domain-containing protein. (208 aa)
ATP6V1AV-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. (617 aa)
PHACTR2Phosphatase and actin regulator. (642 aa)
RAB2ARas-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex; Belongs to the small GTPase superfamily. Rab family. (212 aa)
ENSGALP00000071604Uncharacterized protein. (406 aa)
IQUBIQ motif and ubiquitin domain containing. (704 aa)
ITPR1Uncharacterized protein. (2800 aa)
VPS13BUncharacterized protein. (511 aa)
RAB4ARAB4A, member RAS oncogene family. (255 aa)
CBARPCACN subunit beta associated regulatory protein. (852 aa)
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
HYAL1Hyaluronidase. (436 aa)
BSGBasigin; Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development. (388 aa)
TEKT3Tektin 3. (490 aa)
MOXD1DBH-like monooxygenase protein 1. (614 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (567 aa)
POMT1Uncharacterized protein. (724 aa)
TMEM184ATransmembrane protein 184A. (425 aa)
OPNPPinopsin; Produces a slow and prolonged phototransduction response consistent with the non-visual function of pineal photoreception. (351 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (442 aa)
GHRHRG protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
SYT9Synaptotagmin 9. (528 aa)
HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (702 aa)
SYT8Synaptotagmin 8. (396 aa)
TMPRSS4Uncharacterized protein; Belongs to the peptidase S1 family. (405 aa)
ENKUREnkurin, TRPC channel interacting protein. (253 aa)
SPAG6Uncharacterized protein. (508 aa)
HSPD160 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
E1BU02_CHICKSpermatogenesis associated 1. (335 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (209 aa)
FGGFibrinogen C-terminal domain-containing protein. (438 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.