STRINGSTRING
PHOSPHO1 PHOSPHO1 WNT11 WNT11 IFITM5 IFITM5 CER1 CER1 FBXL15 FBXL15 IFT80 IFT80 SNX10 SNX10 PKDCCB PKDCCB EIF2AK3 EIF2AK3 MMP13 MMP13 PHOSPHO2 PHOSPHO2 ATF4 ATF4 IBSP IBSP ALPL ALPL TMEM38B TMEM38B FGR FGR PTH PTH PKDCC PKDCC ANXA2P2 ANXA2P2 LGR4 LGR4 PTN PTN KLF10 KLF10 CLEC3B CLEC3B ANKH ANKH PTHLH PTHLH PHEX PHEX SOX9 SOX9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. (268 aa)
WNT11Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa)
IFITM5Uncharacterized protein. (131 aa)
CER1Cerberus; Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo; Belongs to the DAN family. (272 aa)
FBXL15F-box and leucine rich repeat protein 15. (299 aa)
IFT80Intraflagellar transport 80. (790 aa)
SNX10PX domain-containing protein. (201 aa)
PKDCCBPIP49_C domain-containing protein. (378 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
MMP13ZnMc domain-containing protein. (530 aa)
PHOSPHO2Phosphatase, orphan 2. (244 aa)
ATF4ATF4. (354 aa)
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). (200 aa)
ALPLAlkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. (519 aa)
TMEM38BTransmembrane protein 38B. (287 aa)
FGRProto-oncogene tyrosine-protein kinase Yrk; May participate in signaling pathways; Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (536 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (496 aa)
ANXA2P2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity); Belongs to the pleiotrophin family. (165 aa)
KLF10Kruppel like factor 10. (436 aa)
CLEC3BTetranectin. (201 aa)
ANKHUncharacterized protein. (493 aa)
PTHLHParathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa)
PHEXUncharacterized protein. (747 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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