(9 nodes) Transmembrane receptor protein tyrosine kinase activator activity network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	BTC	Betacellulin. (171 aa)
	TGFA	EGF-like domain-containing protein. (156 aa)
	GREM1	Gremlin-1; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. (184 aa)
	DGKQ	Diacylglycerol kinase. (904 aa)
	HBEGF	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa)
	AREG	Amphiregulin. (210 aa)
	EREG	EGF-like domain-containing protein. (153 aa)
	EPGN	Epigen; Promotes the growth of epithelial cells. (151 aa)
	AGRN	Agrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	BTC	ENSGALP00000017644	ENSGALP00000041051	Amphiregulin.	Betacellulin.	0.956
AREG	EPGN	ENSGALP00000017644	ENSGALP00000017636	Amphiregulin.	Epigen; Promotes the growth of epithelial cells.	0.935
AREG	EREG	ENSGALP00000017644	ENSGALP00000017642	Amphiregulin.	EGF-like domain-containing protein.	0.989
AREG	HBEGF	ENSGALP00000017644	ENSGALP00000001399	Amphiregulin.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.615
AREG	TGFA	ENSGALP00000017644	ENSGALP00000039726	Amphiregulin.	EGF-like domain-containing protein.	0.851
BTC	AREG	ENSGALP00000041051	ENSGALP00000017644	Betacellulin.	Amphiregulin.	0.956
BTC	EPGN	ENSGALP00000041051	ENSGALP00000017636	Betacellulin.	Epigen; Promotes the growth of epithelial cells.	0.933
BTC	EREG	ENSGALP00000041051	ENSGALP00000017642	Betacellulin.	EGF-like domain-containing protein.	0.975
BTC	HBEGF	ENSGALP00000041051	ENSGALP00000001399	Betacellulin.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.922
BTC	TGFA	ENSGALP00000041051	ENSGALP00000039726	Betacellulin.	EGF-like domain-containing protein.	0.534
EPGN	AREG	ENSGALP00000017636	ENSGALP00000017644	Epigen; Promotes the growth of epithelial cells.	Amphiregulin.	0.935
EPGN	BTC	ENSGALP00000017636	ENSGALP00000041051	Epigen; Promotes the growth of epithelial cells.	Betacellulin.	0.933
EPGN	EREG	ENSGALP00000017636	ENSGALP00000017642	Epigen; Promotes the growth of epithelial cells.	EGF-like domain-containing protein.	0.953
EPGN	HBEGF	ENSGALP00000017636	ENSGALP00000001399	Epigen; Promotes the growth of epithelial cells.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.739
EPGN	TGFA	ENSGALP00000017636	ENSGALP00000039726	Epigen; Promotes the growth of epithelial cells.	EGF-like domain-containing protein.	0.560
EREG	AREG	ENSGALP00000017642	ENSGALP00000017644	EGF-like domain-containing protein.	Amphiregulin.	0.989
EREG	BTC	ENSGALP00000017642	ENSGALP00000041051	EGF-like domain-containing protein.	Betacellulin.	0.975
EREG	EPGN	ENSGALP00000017642	ENSGALP00000017636	EGF-like domain-containing protein.	Epigen; Promotes the growth of epithelial cells.	0.953
EREG	HBEGF	ENSGALP00000017642	ENSGALP00000001399	EGF-like domain-containing protein.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.926
EREG	TGFA	ENSGALP00000017642	ENSGALP00000039726	EGF-like domain-containing protein.	EGF-like domain-containing protein.	0.792