STRINGSTRING
TRAF6 TRAF6 SRC SRC CSF1R CSF1R PAFAH1B1 PAFAH1B1 LRRK1 LRRK1 CREB1 CREB1 ATP6AP1 ATP6AP1 CALCR CALCR SNX10 SNX10 OSTM1 OSTM1 GPR183 GPR183 SH3PXD2A SH3PXD2A TNFSF11 TNFSF11 FOS FOS FAM20C FAM20C GAB2 GAB2 CTNNB1 CTNNB1 EFNA2 EFNA2 TMEM64 TMEM64 FARP2 FARP2 EPHA2 EPHA2 WISP1 WISP1 TNFRSF11A TNFRSF11A GLO1 GLO1 CSF1 CSF1 FAM20CL FAM20CL DCSTAMP DCSTAMP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
CSF1RUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
PAFAH1B1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa)
LRRK1Leucine rich repeat kinase 1. (1998 aa)
CREB1cAMP response element-binding protein. (327 aa)
ATP6AP1Uncharacterized protein. (455 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (469 aa)
SNX10PX domain-containing protein. (201 aa)
OSTM1Uncharacterized protein. (306 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (371 aa)
SH3PXD2ASH3 and PX domains 2A. (1105 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (556 aa)
GAB2GRB2 associated binding protein 2. (681 aa)
CTNNB1Uncharacterized protein. (781 aa)
EFNA2Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling thro [...] (200 aa)
TMEM64Transmembrane protein 64. (573 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1049 aa)
EPHA2EPH receptor A2. (1288 aa)
WISP1Uncharacterized protein. (359 aa)
TNFRSF11ATNF receptor superfamily member 11a. (656 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (180 aa)
CSF1Uncharacterized protein. (493 aa)
FAM20CLFam20C domain-containing protein. (139 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (472 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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