(17 nodes) DNA damage response, signal transduction by p53 class mediator network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	FOXM1	Fork-head domain-containing protein. (795 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (286 aa)
	ATRX	ATRX chromatin remodeler. (2420 aa)
	MDM4	MDM4 regulator of p53. (565 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (590 aa)
	TFAP4	Transcription factor AP-4. (338 aa)
	CASP2	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
	BRCA2	Tower domain-containing protein. (3397 aa)
	MYO6	Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-su [...] (1276 aa)
	LRRC27	Death domain-containing protein. (291 aa)
	PMLL	Uncharacterized protein. (464 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). (785 aa)
	SESN2	Uncharacterized protein. (474 aa)
	CHEK2	Uncharacterized protein. (524 aa)
	E2F7	E2F transcription factor 7. (923 aa)
	ENSGALP00000045724	Uncharacterized protein. (235 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	BRCA2	ENSGALP00000012723	ENSGALP00000027524	ATRX chromatin remodeler.	Tower domain-containing protein.	0.640
BRCA2	ATRX	ENSGALP00000027524	ENSGALP00000012723	Tower domain-containing protein.	ATRX chromatin remodeler.	0.640
BRCA2	CHEK2	ENSGALP00000027524	ENSGALP00000049784	Tower domain-containing protein.	Uncharacterized protein.	0.906
CASP2	ENSGALP00000045724	ENSGALP00000029853	ENSGALP00000045724	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	Uncharacterized protein.	0.608
CASP2	LRRC27	ENSGALP00000029853	ENSGALP00000071942	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	Death domain-containing protein.	0.918
CHEK2	BRCA2	ENSGALP00000049784	ENSGALP00000027524	Uncharacterized protein.	Tower domain-containing protein.	0.906
CHEK2	PPM1D	ENSGALP00000049784	ENSGALP00000045151	Uncharacterized protein.	Protein phosphatase, Mg2+/Mn2+ dependent 1D.	0.639
E2F7	FOXM1	ENSGALP00000048416	ENSGALP00000021851	E2F transcription factor 7.	Fork-head domain-containing protein.	0.435
ENSGALP00000045724	CASP2	ENSGALP00000045724	ENSGALP00000029853	Uncharacterized protein.	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.608
ENSGALP00000045724	LRRC27	ENSGALP00000045724	ENSGALP00000071942	Uncharacterized protein.	Death domain-containing protein.	0.912
FOXM1	E2F7	ENSGALP00000021851	ENSGALP00000048416	Fork-head domain-containing protein.	E2F transcription factor 7.	0.435
LRRC27	CASP2	ENSGALP00000071942	ENSGALP00000029853	Death domain-containing protein.	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.918
LRRC27	ENSGALP00000045724	ENSGALP00000071942	ENSGALP00000045724	Death domain-containing protein.	Uncharacterized protein.	0.912
MDM4	PMLL	ENSGALP00000000906	ENSGALP00000064302	MDM4 regulator of p53.	Uncharacterized protein.	0.421
PMLL	MDM4	ENSGALP00000064302	ENSGALP00000000906	Uncharacterized protein.	MDM4 regulator of p53.	0.421
PPM1D	CHEK2	ENSGALP00000045151	ENSGALP00000049784	Protein phosphatase, Mg2+/Mn2+ dependent 1D.	Uncharacterized protein.	0.639