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CCDC47 CCDC47 HSPA5 HSPA5 HERPUD1 HERPUD1 UBE2J2 UBE2J2 VCP VCP DNAJC18 DNAJC18 UBE4B UBE4B ERLIN2 ERLIN2 AMFR AMFR JKAMP JKAMP STT3B STT3B ANKZF1 ANKZF1 CLGN CLGN UFD1L UFD1L RNF103 RNF103 ECPAS ECPAS WFS1 WFS1 SGTB SGTB DNAJB14 DNAJB14 SEC61B SEC61B FOXRED2 FOXRED2 UBXN4 UBXN4 SELENOS SELENOS EDEM2 EDEM2 ERLIN1 ERLIN1 FAF2 FAF2 CALR3 CALR3 UBE2G2 UBE2G2 ERLEC1 ERLEC1 EDEM1 EDEM1 DNAJC10 DNAJC10 UBXN10 UBXN10 DNAJB9 DNAJB9 DERL1 DERL1 ENSGALP00000069923 ENSGALP00000069923 TTC33 TTC33 PSMC6 PSMC6 UBE2J1 UBE2J1 DERL3 DERL3 LOC430766 LOC430766 DERL2 DERL2 FBXO44 FBXO44 MARCHF6 MARCHF6 HSP90B1 HSP90B1 ENSGALP00000054501 ENSGALP00000054501 FBXO2 FBXO2 AUP1 AUP1 ENSGALP00000051793 ENSGALP00000051793 FAM8A1 FAM8A1 CANX CANX EDEM3 EDEM3 MAN1B1 MAN1B1 SGTA SGTA RNF121 RNF121 RHBDD2 RHBDD2 ENSGALP00000049065 ENSGALP00000049065 YOD1 YOD1 UBE4A UBE4A DNAJB12 DNAJB12 CALR CALR FAF1 FAF1 USP19 USP19 TMEM67 TMEM67
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCDC47Coiled-coil domain containing 47. (481 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa)
UBE2J2Ubiquitin conjugating enzyme E2 J2. (259 aa)
VCPValosin containing protein. (806 aa)
DNAJC18J domain-containing protein. (296 aa)
UBE4BUbiquitination factor E4B. (1346 aa)
ERLIN2ER lipid raft associated 2. (342 aa)
AMFRAutocrine motility factor receptor. (622 aa)
JKAMPUncharacterized protein. (314 aa)
STT3BUncharacterized protein. (801 aa)
ANKZF1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (717 aa)
CLGNCalmegin. (655 aa)
UFD1LUbiquitin fusion-degradation 1-like protein. (307 aa)
RNF103RING-type domain-containing protein. (684 aa)
ECPASEcm29 proteasome adaptor and scaffold. (1872 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
SGTBTPR_REGION domain-containing protein. (304 aa)
DNAJB14J domain-containing protein. (380 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
FOXRED2FAD dependent oxidoreductase domain containing 2. (680 aa)
UBXN4Uncharacterized protein. (216 aa)
SELENOSUncharacterized protein. (207 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (601 aa)
ERLIN1PHB domain-containing protein. (347 aa)
FAF2Fas associated factor family member 2. (445 aa)
CALR3Calreticulin. (420 aa)
UBE2G2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
ERLEC1Endoplasmic reticulum lectin 1. (452 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (616 aa)
DNAJC10DnaJ heat shock protein family (Hsp40) member C10. (797 aa)
UBXN10UBX domain protein 10. (326 aa)
DNAJB9J domain-containing protein. (216 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa)
ENSGALP00000069923Uncharacterized protein. (357 aa)
TTC33Tetratricopeptide repeat domain 33. (304 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa)
UBE2J1UBIQUITIN_CONJUGAT_2 domain-containing protein. (317 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa)
LOC430766Uncharacterized protein; Belongs to the AAA ATPase family. (820 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
FBXO44Uncharacterized protein. (304 aa)
MARCHF6Membrane associated ring-CH-type finger 6. (921 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa)
ENSGALP00000054501Uncharacterized protein. (152 aa)
FBXO2F-box protein 2. (247 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (406 aa)
ENSGALP00000051793Uncharacterized protein. (360 aa)
FAM8A1Family with sequence similarity 8 member A1. (160 aa)
CANXUncharacterized protein. (601 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (933 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (655 aa)
SGTATPR_REGION domain-containing protein. (312 aa)
RNF121Ring finger protein 121. (336 aa)
RHBDD2Rhomboid domain-containing protein. (375 aa)
ENSGALP00000049065Uncharacterized protein; Belongs to the AAA ATPase family. (448 aa)
YOD1Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (346 aa)
UBE4AU-box domain-containing protein. (1074 aa)
DNAJB12J domain-containing protein. (374 aa)
CALRCalreticulin. (416 aa)
FAF1Fas associated factor 1. (650 aa)
USP19Ubiquitin specific peptidase 19. (1434 aa)
TMEM67Transmembrane protein 67. (976 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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