STRINGSTRING
PRC1 PRC1 KLHDC8A KLHDC8A NUDC NUDC HSPA5 HSPA5 CLIC4 CLIC4 GNL3 GNL3 ALKBH4 ALKBH4 C9orf72 C9orf72 CHMP4B CHMP4B KIF14 KIF14 GNAO1 GNAO1 POLDIP2 POLDIP2 USP3 USP3 VPS37B VPS37B SHCBP1 SHCBP1 CENPV CENPV PLK1 PLK1 PKN2 PKN2 TSG101 TSG101 IL16 IL16 CEP55 CEP55 KLHDC8B KLHDC8B INCENP INCENP ARL3 ARL3 ZFYVE19 ZFYVE19 ECT2 ECT2 CENPF CENPF NEK2 NEK2 BIRC6 BIRC6 TBCK TBCK SPAST SPAST SCCPDH SCCPDH URB2 URB2 LOC429032 LOC429032 CENPC CENPC EXOC5 EXOC5 ANKRD54 ANKRD54 KATNA1 KATNA1 EXOC2 EXOC2 VPS4B VPS4B CHMP5 CHMP5 CENPE CENPE NAT10 NAT10 MITD1 MITD1 CHAMP1 CHAMP1 C26H6orf89 C26H6orf89 CEP126 CEP126 KIF20AL KIF20AL BIRC5 BIRC5 ZFYVE26 ZFYVE26 ARF6 ARF6 GNAI1 GNAI1 KIF20BL KIF20BL SIRT2 SIRT2 CRMP1 CRMP1 VPS4A VPS4A LOC768589 LOC768589 RNF8 RNF8 KIF20B KIF20B RCC2 RCC2 RALA RALA CHMP4C CHMP4C MPLKIP MPLKIP ENSGALP00000048237 ENSGALP00000048237 AGBL5 AGBL5 TTC28 TTC28 MICAL1 MICAL1 TXNDC9 TXNDC9 KIF23 KIF23 INCENPL INCENPL USP8 USP8 ENSGALP00000051793 ENSGALP00000051793 UVRAG UVRAG GEM GEM ENSGALP00000053189 ENSGALP00000053189 ENSGALP00000053633 ENSGALP00000053633 PDCD6IP PDCD6IP RAN RAN EXOC7 EXOC7 HSP90B1 HSP90B1 RACGAP1 RACGAP1 RASAL3 RASAL3 KATNBL1 KATNBL1 PIN1 PIN1 IST1 IST1 SDCCAG3 SDCCAG3 DCTN3 DCTN3 SEPT2L SEPT2L GNAI3 GNAI3 ENSGALP00000065041 ENSGALP00000065041 MICAL3 MICAL3 MAP10 MAP10 CDC42 CDC42 ENSGALP00000065966 ENSGALP00000065966 YPEL5 YPEL5 ENSGALP00000066824 ENSGALP00000066824 SEPTIN2 SEPTIN2 ENSGALP00000067038 ENSGALP00000067038 ANXA11 ANXA11 CIT CIT USP8-2 USP8-2 DTNBP1 DTNBP1 LYRM1 LYRM1 ENSGALP00000068764 ENSGALP00000068764 DDX11 DDX11 ERH ERH RAB11FIP3 RAB11FIP3 SVIL SVIL LOC101747255 LOC101747255 SSNA1 SSNA1 ENSGALP00000069624 ENSGALP00000069624 CEP44 CEP44 CTDP1 CTDP1 RALB RALB LOC771190 LOC771190 CHMP3 CHMP3 USP50 USP50 RAB11FIP4 RAB11FIP4 ENSGALP00000071877 ENSGALP00000071877 EXOC4 EXOC4 JTB JTB PIK3C3 PIK3C3 GNAI2 GNAI2 LZTS2 LZTS2 SPART SPART
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRC1Uncharacterized protein. (261 aa)
KLHDC8AKelch domain containing 8A. (253 aa)
NUDCNuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity). (341 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
CLIC4Chloride intracellular channel 4. (253 aa)
GNL3G protein nucleolar 3. (568 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (242 aa)
C9orf72C9orf72-SMCR8 complex subunit. (336 aa)
CHMP4BCharged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (227 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa)
GNAO1Uncharacterized protein. (354 aa)
POLDIP2ApaG domain-containing protein. (373 aa)
USP3Ubiquitin carboxyl-terminal hydrolase. (520 aa)
VPS37BVPS37B subunit of ESCRT-I. (283 aa)
SHCBP1SHC binding and spindle associated 1. (650 aa)
CENPVGFA domain-containing protein. (207 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
PKN2Protein kinase N2. (1042 aa)
TSG101Uncharacterized protein. (390 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1454 aa)
CEP55Centrosomal protein 55. (465 aa)
KLHDC8BKelch domain containing 8B. (354 aa)
INCENPInner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central [...] (877 aa)
ARL3ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (182 aa)
ZFYVE19FYVE-type domain-containing protein. (420 aa)
ECT2Epithelial cell transforming 2. (914 aa)
CENPFUncharacterized protein. (2935 aa)
NEK2Protein kinase domain-containing protein. (444 aa)
BIRC6Baculoviral IAP repeat containing 6. (4856 aa)
TBCKTBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization. (893 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (613 aa)
SCCPDHSacchrp_dh_NADP domain-containing protein. (434 aa)
URB2URB2 ribosome biogenesis homolog. (1543 aa)
LOC429032Rho-GAP domain-containing protein. (568 aa)
CENPCUncharacterized protein. (872 aa)
EXOC5Uncharacterized protein. (867 aa)
ANKRD54Ankyrin repeat domain 54. (168 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (495 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (925 aa)
VPS4BUncharacterized protein; Belongs to the AAA ATPase family. (438 aa)
CHMP5Uncharacterized protein. (219 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2228 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1012 aa)
MITD1Microtubule interacting and trafficking domain containing 1. (250 aa)
CHAMP1Chromosome alignment maintaining phosphoprotein 1. (970 aa)
C26H6orf89Uncharacterized protein. (328 aa)
CEP126Centrosomal protein 126. (1161 aa)
KIF20ALKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (632 aa)
BIRC5Uncharacterized protein. (142 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2561 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
KIF20BLUncharacterized protein. (441 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
CRMP1Collapsin response mediator protein-1A. (683 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
LOC768589Uncharacterized protein. (173 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (529 aa)
KIF20BUncharacterized protein. (659 aa)
RCC2Regulator of chromosome condensation 2. (529 aa)
RALARAS like proto-oncogene A. (206 aa)
CHMP4CUncharacterized protein. (220 aa)
MPLKIPM-phase specific PLK1 interacting protein. (179 aa)
ENSGALP00000048237LNS2 domain-containing protein. (362 aa)
AGBL5ATP/GTP binding protein like 5. (635 aa)
TTC28Tetratricopeptide repeat domain 28. (2428 aa)
MICAL1Uncharacterized protein. (1116 aa)
TXNDC9Thioredoxin domain containing 9. (226 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
INCENPLUncharacterized protein. (837 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa)
ENSGALP00000051793Uncharacterized protein. (360 aa)
UVRAGC2 domain-containing protein. (707 aa)
GEMUncharacterized protein. (297 aa)
ENSGALP00000053189Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (542 aa)
ENSGALP00000053633Uncharacterized protein. (229 aa)
PDCD6IPBRO1 domain-containing protein. (887 aa)
RANGTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (787 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa)
RACGAP1Rac GTPase activating protein 1. (638 aa)
RASAL3Uncharacterized protein. (1938 aa)
KATNBL1Katanin_con80 domain-containing protein. (319 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (162 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
SDCCAG3Uncharacterized protein. (135 aa)
DCTN3Uncharacterized protein. (185 aa)
SEPT2LSeptin-2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] (349 aa)
GNAI3G protein alpha subunit. (354 aa)
ENSGALP00000065041Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (157 aa)
MICAL3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (2229 aa)
MAP10HPHLAWLY domain-containing protein. (906 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
ENSGALP00000065966Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (227 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
ENSGALP00000066824Uncharacterized protein. (105 aa)
SEPTIN2Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (362 aa)
ENSGALP00000067038Uncharacterized protein. (384 aa)
ANXA11Annexin. (496 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2068 aa)
USP8-2Rhodanese domain-containing protein. (602 aa)
DTNBP1Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neuri [...] (369 aa)
LYRM1Uncharacterized protein; Belongs to the complex I LYR family. (122 aa)
ENSGALP00000068764Uncharacterized protein. (495 aa)
DDX11DEAD/H-box helicase 11. (908 aa)
ERHUncharacterized protein. (175 aa)
RAB11FIP3RAB11 family interacting protein 3. (689 aa)
SVILSupervillin. (2303 aa)
LOC101747255Uncharacterized protein. (368 aa)
SSNA1Uncharacterized protein. (114 aa)
ENSGALP00000069624Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (195 aa)
CEP44Centrosomal protein 44. (395 aa)
CTDP1CTD phosphatase subunit 1. (1047 aa)
RALBRAS like proto-oncogene B. (259 aa)
LOC771190Uncharacterized protein. (116 aa)
CHMP3Uncharacterized protein. (241 aa)
USP50UCH domain-containing protein. (115 aa)
RAB11FIP4RAB11 family interacting protein 4. (496 aa)
ENSGALP00000071877Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (208 aa)
EXOC4Sec8_exocyst domain-containing protein. (1018 aa)
JTBUncharacterized protein. (90 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2. (460 aa)
LZTS2Leucine zipper tumor suppressor 2. (682 aa)
SPARTSpartin. (631 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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