(23 nodes) Neutrophil chemotaxis network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

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Your Input:
	GBF1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1863 aa)
	EDN2	Endothelin-2. (179 aa)
	BSG	Basigin; Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development. (388 aa)
	CSF3R	Uncharacterized protein. (827 aa)
	CCL20	C-C motif chemokine. (100 aa)
	CCL19	C-C motif chemokine. (108 aa)
	CCL4-2	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties. (96 aa)
	ITGA9	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa)
	LGALS3	Galectin. (258 aa)
	CXCR1	Putative C-X-C chemokine receptor type 1, CXCR1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	CCL5	C-C motif chemokine. (90 aa)
	CCL19-2	SCY domain-containing protein. (99 aa)
	CATH1	Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response. (148 aa)
	IL8L2	Interleukin-8; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. (103 aa)
	CX3CL1	SCY domain-containing protein. (496 aa)
	TGFB2	Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa)
	TSTD1	Uncharacterized protein. (358 aa)
	XCL1	Lymphotactin. (97 aa)
	SYK	Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
	SLC37A4	Solute carrier family 37 member 4. (451 aa)
	CKLF	Chemokine like factor. (145 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BSG	LGALS3	ENSGALP00000002020	ENSGALP00000055146	Basigin; Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development.	Galectin.	0.432
CCL19	CCL19-2	ENSGALP00000068348	ENSGALP00000043299	C-C motif chemokine.	SCY domain-containing protein.	0.841
CCL19	CCL20	ENSGALP00000068348	ENSGALP00000004738	C-C motif chemokine.	C-C motif chemokine.	0.901
CCL19	CCL4-2	ENSGALP00000068348	ENSGALP00000067768	C-C motif chemokine.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.819
CCL19	CCL5	ENSGALP00000068348	ENSGALP00000049143	C-C motif chemokine.	C-C motif chemokine.	0.988
CCL19	CX3CL1	ENSGALP00000068348	ENSGALP00000041151	C-C motif chemokine.	SCY domain-containing protein.	0.716
CCL19	CXCR1	ENSGALP00000068348	ENSGALP00000054150	C-C motif chemokine.	Putative C-X-C chemokine receptor type 1, CXCR1; Belongs to the G-protein coupled receptor 1 family.	0.757
CCL19	IL8L2	ENSGALP00000068348	ENSGALP00000041738	C-C motif chemokine.	Interleukin-8; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.	0.606
CCL19	XCL1	ENSGALP00000068348	ENSGALP00000024539	C-C motif chemokine.	Lymphotactin.	0.903
CCL19-2	CCL19	ENSGALP00000043299	ENSGALP00000068348	SCY domain-containing protein.	C-C motif chemokine.	0.841
CCL19-2	CCL20	ENSGALP00000043299	ENSGALP00000004738	SCY domain-containing protein.	C-C motif chemokine.	0.880
CCL19-2	CCL4-2	ENSGALP00000043299	ENSGALP00000067768	SCY domain-containing protein.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.828
CCL19-2	CCL5	ENSGALP00000043299	ENSGALP00000049143	SCY domain-containing protein.	C-C motif chemokine.	0.881
CCL19-2	CSF3R	ENSGALP00000043299	ENSGALP00000003295	SCY domain-containing protein.	Uncharacterized protein.	0.440
CCL19-2	CX3CL1	ENSGALP00000043299	ENSGALP00000041151	SCY domain-containing protein.	SCY domain-containing protein.	0.722
CCL19-2	CXCR1	ENSGALP00000043299	ENSGALP00000054150	SCY domain-containing protein.	Putative C-X-C chemokine receptor type 1, CXCR1; Belongs to the G-protein coupled receptor 1 family.	0.746
CCL19-2	IL8L2	ENSGALP00000043299	ENSGALP00000041738	SCY domain-containing protein.	Interleukin-8; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.	0.604
CCL19-2	XCL1	ENSGALP00000043299	ENSGALP00000024539	SCY domain-containing protein.	Lymphotactin.	0.608
CCL20	CCL19	ENSGALP00000004738	ENSGALP00000068348	C-C motif chemokine.	C-C motif chemokine.	0.901
CCL20	CCL19-2	ENSGALP00000004738	ENSGALP00000043299	C-C motif chemokine.	SCY domain-containing protein.	0.880