(46 nodes) Leukocyte chemotaxis network (Gallus gallus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	CCL4-2	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties. (96 aa)
	EDN2	Endothelin-2. (179 aa)
	BSG	Basigin; Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development. (388 aa)
	CSF3R	Uncharacterized protein. (827 aa)
	CCL20	C-C motif chemokine. (100 aa)
	CKLF	Chemokine like factor. (145 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1508 aa)
	GBF1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1863 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1454 aa)
	SLC37A4	Solute carrier family 37 member 4. (451 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (843 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
	ANO6	Anoctamin. (912 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	SYK	Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
	XCL1	Lymphotactin. (97 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	ARHGEF5	Uncharacterized protein. (1733 aa)
	TSTD1	Uncharacterized protein. (358 aa)
	TGFB2	Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
	EDNRB	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
	PTPRO	Uncharacterized protein. (1268 aa)
	TNFSF11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
	CX3CL1	SCY domain-containing protein. (496 aa)
	IL8L2	Interleukin-8; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. (103 aa)
	CATH1	Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response. (148 aa)
	CXCR5	Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	CCL19-2	SCY domain-containing protein. (99 aa)
	SCG2	Secretogranin II. (629 aa)
	GAS6	Growth arrest specific 6. (667 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (487 aa)
	CCR7	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	CCL5	C-C motif chemokine. (90 aa)
	TAFA4	TAFA chemokine like family member 4. (173 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
	CXCR1	Putative C-X-C chemokine receptor type 1, CXCR1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	LGALS3	Galectin. (258 aa)
	ITGA9	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa)
	K4LB56_CHICK	CD150. (333 aa)
	CCL19	C-C motif chemokine. (108 aa)
	FFAR2L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	LOC107050658	Free fatty acid receptor 2-like. (367 aa)
	IL17RA	SEFIR domain-containing protein. (978 aa)
	EDNRB2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	CCL4-2	ENSGALP00000032184	ENSGALP00000067768	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.431
ANXA1	CX3CL1	ENSGALP00000032184	ENSGALP00000041151	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	SCY domain-containing protein.	0.435
ANXA1	LGALS3	ENSGALP00000032184	ENSGALP00000055146	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Galectin.	0.642
BSG	LGALS3	ENSGALP00000002020	ENSGALP00000055146	Basigin; Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development.	Galectin.	0.432
CCL19	CCL19-2	ENSGALP00000068348	ENSGALP00000043299	C-C motif chemokine.	SCY domain-containing protein.	0.841
CCL19	CCL20	ENSGALP00000068348	ENSGALP00000004738	C-C motif chemokine.	C-C motif chemokine.	0.901
CCL19	CCL4-2	ENSGALP00000068348	ENSGALP00000067768	C-C motif chemokine.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.819
CCL19	CCL5	ENSGALP00000068348	ENSGALP00000049143	C-C motif chemokine.	C-C motif chemokine.	0.988
CCL19	CCR7	ENSGALP00000068348	ENSGALP00000048400	C-C motif chemokine.	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL19	CX3CL1	ENSGALP00000068348	ENSGALP00000041151	C-C motif chemokine.	SCY domain-containing protein.	0.716
CCL19	CXCR1	ENSGALP00000068348	ENSGALP00000054150	C-C motif chemokine.	Putative C-X-C chemokine receptor type 1, CXCR1; Belongs to the G-protein coupled receptor 1 family.	0.757
CCL19	CXCR5	ENSGALP00000068348	ENSGALP00000042818	C-C motif chemokine.	Chemokine receptor; Belongs to the G-protein coupled receptor 1 family.	0.966
CCL19	IL8L2	ENSGALP00000068348	ENSGALP00000041738	C-C motif chemokine.	Interleukin-8; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.	0.606
CCL19	XCL1	ENSGALP00000068348	ENSGALP00000024539	C-C motif chemokine.	Lymphotactin.	0.903
CCL19-2	CCL19	ENSGALP00000043299	ENSGALP00000068348	SCY domain-containing protein.	C-C motif chemokine.	0.841
CCL19-2	CCL20	ENSGALP00000043299	ENSGALP00000004738	SCY domain-containing protein.	C-C motif chemokine.	0.880
CCL19-2	CCL4-2	ENSGALP00000043299	ENSGALP00000067768	SCY domain-containing protein.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.828
CCL19-2	CCL5	ENSGALP00000043299	ENSGALP00000049143	SCY domain-containing protein.	C-C motif chemokine.	0.881
CCL19-2	CCR7	ENSGALP00000043299	ENSGALP00000048400	SCY domain-containing protein.	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL19-2	CSF3R	ENSGALP00000043299	ENSGALP00000003295	SCY domain-containing protein.	Uncharacterized protein.	0.440