(71 nodes) Synaptic vesicle membrane network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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co-expression

protein homology

Your Input:
	TPRG1L	Tumor protein p63 regulated 1 like. (270 aa)
	SLC18A1	Solute carrier family 18 member A1. (515 aa)
	UNC13B	Unc-13 homolog B. (1574 aa)
	C11H16orf70	Uncharacterized protein. (423 aa)
	STX10	Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
	SYT12	C2 domain-containing protein. (417 aa)
	SYT9	Synaptotagmin 9. (528 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1595 aa)
	SYP	MARVEL domain-containing protein. (338 aa)
	RAB35	Uncharacterized protein. (201 aa)
	ATP6AP1	Uncharacterized protein. (455 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
	SLC18A2	Solute carrier family 18 member A2. (633 aa)
	BIN1	Uncharacterized protein. (442 aa)
	SYNGR1	Synaptogyrin. (233 aa)
	TMEM163	Transmembrane protein 163. (274 aa)
	GABRA2	Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (874 aa)
	SV2C	Synaptic vesicle glycoprotein 2C. (727 aa)
	BSN	Bassoon presynaptic cytomatrix protein. (3627 aa)
	ATP6AP2	Uncharacterized protein. (354 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
	CPLX3	Uncharacterized protein. (157 aa)
	SYT1	Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family. (430 aa)
	SYPL1	MARVEL domain-containing protein. (236 aa)
	SYNGR2	Synaptogyrin. (225 aa)
	SYNDIG1	Synapse differentiation inducing 1. (256 aa)
	UNC13A	Uncharacterized protein. (1738 aa)
	SVOP	SV2 related protein. (548 aa)
	UNC13C	Uncharacterized protein. (1097 aa)
	RAB26	RAB26, member RAS oncogene family. (190 aa)
	AMPH	Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. (682 aa)
	SYT2	Synaptotagmin 2. (490 aa)
	ATP6V0A1	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (863 aa)
	BORCS5	BLOC-1-related complex subunit 5; As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS5 family. (196 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
	PTPRD	Protein tyrosine phosphatase receptor type D. (1963 aa)
	LRRK2	Uncharacterized protein. (2557 aa)
	GRIA1	Uncharacterized protein. (902 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (228 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (114 aa)
	BCL2L1	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
	SYN3	Synapsin III. (582 aa)
	SLC32A1	Solute carrier family 32 member 1. (521 aa)
	GAD2	Glutamate decarboxylase 2. (807 aa)
	STX16	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (326 aa)
	LOC100857259	Aa_trans domain-containing protein. (486 aa)
	SYPL2	Synaptophysin like 2. (425 aa)
	SLC17A6	MFS domain-containing protein. (585 aa)
	PTPRS	Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] (1924 aa)
	SLC17A8	MFS domain-containing protein. (587 aa)
	SYT7	Synaptotagmin 7. (403 aa)
	SV2B	Synaptic vesicle glycoprotein 2B. (705 aa)
	MCTP2	Multiple C2 and transmembrane domain containing 2. (895 aa)
	LAMP5	Lysosomal associated membrane protein family member 5. (344 aa)
	SCAMP1	Secretory carrier-associated membrane protein. (481 aa)
	SLC30A3	Solute carrier family 30 member 3. (439 aa)
	UNC13C-2	Uncharacterized protein. (411 aa)
	DTNBP1	Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neuri [...] (369 aa)
	SYN2	Synapsin_C domain-containing protein. (296 aa)
	TRARG1	Trafficking regulator of GLUT4 (SLC2A4) 1. (176 aa)
	SNAP47	Synaptosome associated protein 47. (461 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (245 aa)
	SYNGR3	MARVEL domain-containing protein. (295 aa)
	ENSGALP00000070006	Synaptophysin. (351 aa)
	ENSGALP00000070662	Uncharacterized protein. (243 aa)
	DNM1L	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
	SV2A	Synaptic vesicle glycoprotein 2A. (751 aa)
	MCTP1	Multiple C2 and transmembrane domain containing 1. (954 aa)
	VAMP1	V-SNARE coiled-coil homology domain-containing protein. (119 aa)
	ENSGALP00000074167	Uncharacterized protein. (178 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC8	WFS1	ENSGALP00000009950	ENSGALP00000024991	ATP binding cassette subfamily C member 8.	Wolframin ER transmembrane glycoprotein.	0.411
AMPH	BIN1	ENSGALP00000046761	ENSGALP00000018797	Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.	Uncharacterized protein.	0.901
AMPH	CLTA	ENSGALP00000046761	ENSGALP00000069813	Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.480
AMPH	CLTB	ENSGALP00000046761	ENSGALP00000053603	Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.490
AMPH	SYT1	ENSGALP00000046761	ENSGALP00000042075	Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.	Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family.	0.415
ATP6AP1	ATP6AP2	ENSGALP00000014341	ENSGALP00000035865	Uncharacterized protein.	Uncharacterized protein.	0.999
ATP6AP1	ATP6V0A1	ENSGALP00000014341	ENSGALP00000048041	Uncharacterized protein.	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	0.989
ATP6AP1	ATP6V0C	ENSGALP00000014341	ENSGALP00000015002	Uncharacterized protein.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.998
ATP6AP1	ATP6V1C1	ENSGALP00000014341	ENSGALP00000049567	Uncharacterized protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.970
ATP6AP2	ATP6AP1	ENSGALP00000035865	ENSGALP00000014341	Uncharacterized protein.	Uncharacterized protein.	0.999
ATP6AP2	ATP6V0A1	ENSGALP00000035865	ENSGALP00000048041	Uncharacterized protein.	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	0.962
ATP6AP2	ATP6V0C	ENSGALP00000035865	ENSGALP00000015002	Uncharacterized protein.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.982
ATP6AP2	ATP6V1C1	ENSGALP00000035865	ENSGALP00000049567	Uncharacterized protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.958
ATP6V0A1	ATP6AP1	ENSGALP00000048041	ENSGALP00000014341	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	Uncharacterized protein.	0.989
ATP6V0A1	ATP6AP2	ENSGALP00000048041	ENSGALP00000035865	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	Uncharacterized protein.	0.962
ATP6V0A1	ATP6V0C	ENSGALP00000048041	ENSGALP00000015002	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.997
ATP6V0A1	ATP6V1C1	ENSGALP00000048041	ENSGALP00000049567	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.986
ATP6V0C	ATP6AP1	ENSGALP00000015002	ENSGALP00000014341	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.998
ATP6V0C	ATP6AP2	ENSGALP00000015002	ENSGALP00000035865	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.982
ATP6V0C	ATP6V0A1	ENSGALP00000015002	ENSGALP00000048041	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	0.997