STRINGSTRING
BMP6 BMP6 S1PR2 S1PR2 APOLD1 APOLD1 GATA3 GATA3 MMP9 MMP9 ACVRL1 ACVRL1 ENSGALP00000068437 ENSGALP00000068437 SPRED1 SPRED1 DLL1 DLL1 ROCK2 ROCK2 TP63 TP63 H2AFY2 H2AFY2 BTG1 BTG1 TBX2 TBX2 ETV4 ETV4 AJAP1 AJAP1 PRKX PRKX LOC107049024 LOC107049024 ROCK1 ROCK1 GRHL2 GRHL2 ID1 ID1 MAFG MAFG IKBKB IKBKB IL1B IL1B TNFRSF1A TNFRSF1A SMO SMO NUMA1 NUMA1 SFRP4 SFRP4 PTCH2 PTCH2 GRHL1 GRHL1 CTNNB1 CTNNB1 TBX3 TBX3 ENSGALP00000044025 ENSGALP00000044025 ATOH8 ATOH8 CAV1 CAV1 CD24 CD24 TMEM100 TMEM100 ZDHHC21 ZDHHC21 WNT9B WNT9B SOX9 SOX9 NFE2L1 NFE2L1 NME2 NME2 ADD1 ADD1 AHI1 AHI1 BMP4 BMP4 MAFF MAFF NKX6-3 NKX6-3 WWTR1 WWTR1 JAG1 JAG1 COMMD5 COMMD5 KLF7 KLF7 CAV3 CAV3 LHX5 LHX5 APOA1 APOA1 LHX1 LHX1 VCL VCL GDNF GDNF FOXN1 FOXN1 NOG NOG FRZB FRZB PROC PROC MED1 MED1 CLDN5 CLDN5 TP73 TP73 KDF1 KDF1 ERRFI1 ERRFI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP6Bone morphogenetic protein 6. (434 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
APOLD1Apolipoprotein L domain containing 1. (246 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
MMP9Uncharacterized protein. (713 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
ENSGALP00000068437Uncharacterized protein. (99 aa)
SPRED1Uncharacterized protein. (443 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
H2AFY2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
BTG1Protein BTG1; Anti-proliferative protein; Belongs to the BTG family. (352 aa)
TBX2T-box transcription factor 2. (693 aa)
ETV4ETS variant 4. (530 aa)
AJAP1Adherens junctions associated protein 1. (266 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (366 aa)
LOC107049024Epidermal differentiation protein. (316 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
GRHL2CP2 domain-containing protein. (234 aa)
ID1Helix-loop-helix protein. (118 aa)
MAFGTranscription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. May be involved in signal transduction of extracellula [...] (162 aa)
IKBKBProtein kinase domain-containing protein. (753 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
TNFRSF1AUncharacterized protein. (427 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
NUMA1Uncharacterized protein. (2226 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
PTCH2Patched 2. (1266 aa)
GRHL1TATA box-binding protein-associated factor RNA polymerase I subunit B. (638 aa)
CTNNB1Uncharacterized protein. (781 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
ATOH8BHLH domain-containing protein. (218 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
CD24Uncharacterized protein. (87 aa)
TMEM100Transmembrane protein 100. (134 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
NFE2L1Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage and translocates into the nucleus to form t [...] (887 aa)
NME2Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). (153 aa)
ADD1Aldolase_II domain-containing protein. (736 aa)
AHI1Abelson helper integration site 1. (1242 aa)
BMP4Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
MAFFTranscription factor MafF; Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response; Belongs to the bZIP family. Maf subfamily. (149 aa)
NKX6-3NK6 homeobox 3. (259 aa)
WWTR1WW domain containing transcription regulator 1. (386 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
COMMD5COMM domain-containing protein. (226 aa)
KLF7Uncharacterized protein. (296 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LHX5LIM homeobox protein 5. (402 aa)
APOA1Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
GDNFGlial cell derived neurotrophic factor. (209 aa)
FOXN1Forkhead box N1. (636 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis. (387 aa)
FRZBSecreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (315 aa)
PROCUncharacterized protein. (433 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
KDF1Keratinocyte differentiation factor 1. (417 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (465 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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