(16 nodes) Rough endoplasmic reticulum membrane network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SEC61B	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	SRPRB	Uncharacterized protein. (258 aa)
	SEC61A1	SEC61 translocon alpha 1 subunit. (476 aa)
	TMEM97	Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (171 aa)
	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. (730 aa)
	TMEM57	Uncharacterized protein. (662 aa)
	CCDC47	Coiled-coil domain containing 47. (481 aa)
	SRPRA	Uncharacterized protein. (676 aa)
	RPS28	Uncharacterized protein. (69 aa)
	SUCO	SUN domain containing ossification factor. (1251 aa)
	SEC61G	Uncharacterized protein. (68 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (681 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (890 aa)
	SEC61A2	Plug_translocon domain-containing protein. (476 aa)
	EPM2A	Laforin. (319 aa)
	SEC63	SEC63 homolog, protein translocation regulator. (755 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC47	SEC61A1	ENSGALP00000000782	ENSGALP00000009577	Coiled-coil domain containing 47.	SEC61 translocon alpha 1 subunit.	0.700
CCDC47	SEC61A2	ENSGALP00000000782	ENSGALP00000045021	Coiled-coil domain containing 47.	Plug_translocon domain-containing protein.	0.701
CCDC47	SEC61B	ENSGALP00000000782	ENSGALP00000022049	Coiled-coil domain containing 47.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.729
CCDC47	SEC61G	ENSGALP00000000782	ENSGALP00000060425	Coiled-coil domain containing 47.	Uncharacterized protein.	0.712
CCDC47	SUCO	ENSGALP00000000782	ENSGALP00000068357	Coiled-coil domain containing 47.	SUN domain containing ossification factor.	0.483
RPS28	SEC61A1	ENSGALP00000070639	ENSGALP00000009577	Uncharacterized protein.	SEC61 translocon alpha 1 subunit.	0.525
RPS28	SEC61A2	ENSGALP00000070639	ENSGALP00000045021	Uncharacterized protein.	Plug_translocon domain-containing protein.	0.542
RPS28	SEC61B	ENSGALP00000070639	ENSGALP00000022049	Uncharacterized protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.867
RPS28	SEC61G	ENSGALP00000070639	ENSGALP00000060425	Uncharacterized protein.	Uncharacterized protein.	0.713
SEC61A1	CCDC47	ENSGALP00000009577	ENSGALP00000000782	SEC61 translocon alpha 1 subunit.	Coiled-coil domain containing 47.	0.700
SEC61A1	RPS28	ENSGALP00000009577	ENSGALP00000070639	SEC61 translocon alpha 1 subunit.	Uncharacterized protein.	0.525
SEC61A1	SEC61A2	ENSGALP00000009577	ENSGALP00000045021	SEC61 translocon alpha 1 subunit.	Plug_translocon domain-containing protein.	0.901
SEC61A1	SEC61B	ENSGALP00000009577	ENSGALP00000022049	SEC61 translocon alpha 1 subunit.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.993
SEC61A1	SEC61G	ENSGALP00000009577	ENSGALP00000060425	SEC61 translocon alpha 1 subunit.	Uncharacterized protein.	0.992
SEC61A1	SEC63	ENSGALP00000009577	ENSGALP00000024664	SEC61 translocon alpha 1 subunit.	SEC63 homolog, protein translocation regulator.	0.998
SEC61A1	SRPRA	ENSGALP00000009577	ENSGALP00000072364	SEC61 translocon alpha 1 subunit.	Uncharacterized protein.	0.805
SEC61A1	SRPRB	ENSGALP00000009577	ENSGALP00000010404	SEC61 translocon alpha 1 subunit.	Uncharacterized protein.	0.563
SEC61A2	CCDC47	ENSGALP00000045021	ENSGALP00000000782	Plug_translocon domain-containing protein.	Coiled-coil domain containing 47.	0.701
SEC61A2	RPS28	ENSGALP00000045021	ENSGALP00000070639	Plug_translocon domain-containing protein.	Uncharacterized protein.	0.542
SEC61A2	SEC61A1	ENSGALP00000045021	ENSGALP00000009577	Plug_translocon domain-containing protein.	SEC61 translocon alpha 1 subunit.	0.901