STRINGSTRING
PHLPP2 PHLPP2 SEMA7A SEMA7A LHX3 LHX3 BBS4 BBS4 KIF14 KIF14 UCHL5 UCHL5 LRRC45 LRRC45 E1C066_CHICK E1C066_CHICK DKK1 DKK1 GHRH GHRH MFSD2A MFSD2A HTR6 HTR6 DLX1 DLX1 DRAXIN DRAXIN WNT7A WNT7A AQP1 AQP1 GHRHR GHRHR LHX1 LHX1 CSF1R CSF1R PAFAH1B1 PAFAH1B1 CRKL CRKL C14H16orf45 C14H16orf45 RYK RYK TRA2B TRA2B JAKMIP2 JAKMIP2 DPCD DPCD RTN4R RTN4R DRD2 DRD2 PEX13 PEX13 ATRX ATRX DCX DCX RELN RELN LHX5 LHX5 SSTR4 SSTR4 CREB1 CREB1 NEUROD1 NEUROD1 FEZF1 FEZF1 MKKS MKKS BTBD3 BTBD3 DLX5 DLX5 FOXP2 FOXP2 MPP5 MPP5 SLC7A11 SLC7A11 FRS2 FRS2 SSTR1 SSTR1 ZSWIM5 ZSWIM5 TTC8 TTC8 LRP8 LRP8 CCDC85C CCDC85C LHX8 LHX8 SCYL2 SCYL2 MAS1 MAS1 EPHA5 EPHA5 FAT4 FAT4 NDNF NDNF METTL14 METTL14 RAB3GAP1 RAB3GAP1 NIN NIN AGTPBP1 AGTPBP1 CGTL CGTL NR4A3 NR4A3 VIP VIP C1H12ORF57 C1H12ORF57 PCSK1 PCSK1 ZSWIM6 ZSWIM6 TENT2 TENT2 MSX1 MSX1 CDH2 CDH2 HOOK3 HOOK3 ARL13B ARL13B JAKMIP1 JAKMIP1 TACC3 TACC3 AKIRIN2 AKIRIN2 PTCHD1 PTCHD1 EFHC1 EFHC1 PTCHD4 PTCHD4 NRGN NRGN FGF8 FGF8 NF2 NF2 DCT DCT APP APP E1C5H3_CHICK E1C5H3_CHICK APAF1 APAF1 TTC21B TTC21B LOC421195 LOC421195 SUN2 SUN2 OTP OTP EOMES EOMES C1H21ORF91 C1H21ORF91 ISL1 ISL1 SALL1 SALL1 NUMB NUMB RAX RAX LHX6 LHX6 TRAPPC9 TRAPPC9 NFIB NFIB TBX3 TBX3 NRP2 NRP2 SLIT2 SLIT2 SLC4A10 SLC4A10 SOX2 SOX2 CTNNB1 CTNNB1 NR4A2 NR4A2 POU4F1 POU4F1 PITX2 PITX2 CDK5R1 CDK5R1 CHD9 CHD9 OLIG2 OLIG2 ENSGALP00000047504 ENSGALP00000047504 CDH15 CDH15 POU3F4 POU3F4 ENSGALP00000048186 ENSGALP00000048186 TBR1 TBR1 ARHGAP35 ARHGAP35 KDM1A KDM1A DISC1 DISC1 ARX ARX SMO SMO ADGRG1 ADGRG1 GLI1 GLI1 GSX2 GSX2 NARS NARS SOX1 SOX1 PGAP1 PGAP1 ZDHHC16 ZDHHC16 RAPGEF2 RAPGEF2 SEMA3E SEMA3E GBX2 GBX2 HTRA2 HTRA2 DLX2 DLX2 EMX1 EMX1 LRRK2 LRRK2 CCKAR CCKAR GSX1 GSX1 SRF SRF FOXG1 FOXG1 UNCX UNCX ALDH1A3 ALDH1A3 ZNF335 ZNF335 TCTN1 TCTN1 SLC1A2 SLC1A2 DYNC2H1 DYNC2H1 CHD7 CHD7 BCL11B BCL11B BBS2 BBS2 LOC100859602 LOC100859602 POU3F3 POU3F3 TBX2 TBX2 NR3C2 NR3C2 SIX3 SIX3 LHX4 LHX4 GSC GSC METTL3 METTL3 HESX1 HESX1 TMEM108 TMEM108 HDAC1 HDAC1 LOC428505 LOC428505 BCAN BCAN MCPH1 MCPH1 FEZ1 FEZ1 UQCRQ UQCRQ RFX4 RFX4 DIXDC1 DIXDC1 SUN1 SUN1 GDF7 GDF7 LOC770839 LOC770839 ATP2B4 ATP2B4 ENSGALP00000066137 ENSGALP00000066137 JAKMIP3 JAKMIP3 LDLR LDLR TAL2 TAL2 EMX2 EMX2 TOX TOX CEP120 CEP120 NEUROD6 NEUROD6 TSC1 TSC1 SETD2 SETD2 CDK5 CDK5 ENSGALP00000068920 ENSGALP00000068920 NTRK2 NTRK2 AKNA AKNA RPGRIP1L RPGRIP1L DCLK1 DCLK1 MGARP MGARP PSEN1 PSEN1 FYN FYN ENSGALP00000069955 ENSGALP00000069955 FBXO45 FBXO45 HSD3B1 HSD3B1 ENSGALP00000070347 ENSGALP00000070347 ENSGALP00000070762 ENSGALP00000070762 ENSGALP00000070978 ENSGALP00000070978 SZT2 SZT2 LOC107050371 LOC107050371 NF2L NF2L POU3F1 POU3F1 LOC776146 LOC776146 OTX1 OTX1 BTG2 BTG2 STIL STIL SALL3 SALL3 LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1397 aa)
SEMA7ASema domain-containing protein; Belongs to the semaphorin family. (636 aa)
LHX3LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa)
BBS4TPR_REGION domain-containing protein. (532 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (331 aa)
LRRC45Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. (670 aa)
E1C066_CHICKUncharacterized protein. (258 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (240 aa)
GHRHGHRH/PACAP-like. (172 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (528 aa)
HTR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (433 aa)
DLX1Homeodomain transcription factor DLX1. (255 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Binds directly to the neurites and growth cones. (349 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
GHRHRG protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
CSF1RUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
PAFAH1B1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa)
CRKLCRK like proto-oncogene, adaptor protein. (193 aa)
C14H16orf45BMERB domain-containing protein. (204 aa)
RYKReceptor like tyrosine kinase. (481 aa)
TRA2BTransformer-2 beta. (289 aa)
JAKMIP2Janus kinase and microtubule interacting protein 2. (820 aa)
DPCDUncharacterized protein. (209 aa)
RTN4RReticulon 4 receptor. (483 aa)
DRD2Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
PEX13SH3 domain-containing protein. (397 aa)
ATRXATRX chromatin remodeler. (2420 aa)
DCXDoublecortin. (361 aa)
RELNReelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...] (3462 aa)
LHX5LIM homeobox protein 5. (402 aa)
SSTR4Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family. (377 aa)
CREB1cAMP response element-binding protein. (327 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
FEZF1FEZ family zinc finger 1. (438 aa)
MKKSUncharacterized protein. (570 aa)
BTBD3BTB domain containing 3. (520 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
FOXP2Fork-head domain-containing protein. (513 aa)
MPP5Uncharacterized protein; Belongs to the MAGUK family. (675 aa)
SLC7A11Solute carrier family 7 member 11 xCT. (501 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ZSWIM5Zinc finger SWIM-type containing 5. (1321 aa)
TTC8Tetratricopeptide repeat domain 8. (567 aa)
LRP8Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of th [...] (917 aa)
CCDC85CCoiled-coil domain containing 85C. (393 aa)
LHX8Uncharacterized protein. (347 aa)
SCYL2Protein kinase domain-containing protein. (756 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa)
EPHA5Ephrin type-A receptor 5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in [...] (1013 aa)
FAT4FAT atypical cadherin 4. (5022 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. (459 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1014 aa)
NINNinein. (2081 aa)
AGTPBP1Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1225 aa)
CGTLUncharacterized protein. (474 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (609 aa)
VIPIntestinal peptide PHI-27-like; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (200 aa)
C1H12ORF57Uncharacterized protein. (126 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
ZSWIM6SWIM-type domain-containing protein. (1157 aa)
TENT2Terminal nucleotidyltransferase 2. (499 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
HOOK3Hook microtubule tethering protein 3. (713 aa)
ARL13BADP ribosylation factor like GTPase 13B. (425 aa)
JAKMIP1Janus kinase and microtubule interacting protein 1. (826 aa)
TACC3TACC_C domain-containing protein. (891 aa)
AKIRIN2Akirin. (191 aa)
PTCHD1Patched domain containing 1. (914 aa)
EFHC1EF-hand domain containing 1. (642 aa)
PTCHD4SSD domain-containing protein. (904 aa)
NRGNUncharacterized protein. (73 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
NF2FERM domain-containing protein. (595 aa)
DCTL-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
E1C5H3_CHICKSUN domain-containing protein. (197 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
TTC21BTetratricopeptide repeat domain 21B. (1411 aa)
LOC421195Uncharacterized protein. (2510 aa)
SUN2Sad1 and UNC84 domain containing 2. (601 aa)
OTPOrthopedia homeobox. (325 aa)
EOMEST-box_assoc domain-containing protein. (661 aa)
C1H21ORF91Protein EURL; Plays a role in cortical progenitor cell proliferation and differentiation. May promote dendritic spine development of post- migratory cortical projection neurons by modulating the beta-catenin signaling pathway; Belongs to the EURL family. (292 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
SALL1Uncharacterized protein. (1308 aa)
NUMBPID domain-containing protein. (620 aa)
RAXRetinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (317 aa)
LHX6LIM homeobox 6. (380 aa)
TRAPPC9Trafficking protein particle complex 9. (996 aa)
NFIBNuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (560 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
NRP2Uncharacterized protein. (969 aa)
SLIT2Uncharacterized protein. (1533 aa)
SLC4A10Anion exchange protein. (1116 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
CTNNB1Uncharacterized protein. (781 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (605 aa)
POU4F1POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
PITX2Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa)
CDK5R1Cyclin dependent kinase 5 regulatory subunit 1. (300 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2820 aa)
OLIG2Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
ENSGALP00000047504Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (367 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
POU3F4POU domain protein. (247 aa)
ENSGALP00000048186Uncharacterized protein. (528 aa)
TBR1T-box brain transcription factor 1. (677 aa)
ARHGAP35Rho GTPase activating protein 35. (1613 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa)
DISC1DISC1 scaffold protein. (856 aa)
ARXAristaless related homeobox. (513 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (695 aa)
GLI1Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. (1281 aa)
GSX2GS homeobox 2. (263 aa)
NARSAA_TRNA_LIGASE_II domain-containing protein. (559 aa)
SOX1Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa)
PGAP1Post-GPI attachment to proteins 1. (866 aa)
ZDHHC16Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (375 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1652 aa)
SEMA3ESemaphorin-3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity); Belongs to the se [...] (779 aa)
GBX2Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa)
HTRA2HtrA serine peptidase 2. (200 aa)
DLX2Distal-less homeobox 2. (253 aa)
EMX1Empty spiracles homeobox 1. (235 aa)
LRRK2Uncharacterized protein. (2557 aa)
CCKARCholecystokinin type 1 receptor; Belongs to the G-protein coupled receptor 1 family. (429 aa)
GSX1GS homeobox 1. (247 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
UNCXHomeobox domain-containing protein. (199 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
ZNF335Uncharacterized protein. (1473 aa)
TCTN1Tectonic family member 1. (565 aa)
SLC1A2Amino acid transporter. (554 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4301 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (884 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
LOC100859602SWIM-type domain-containing protein. (1005 aa)
POU3F3POU domain protein. (445 aa)
TBX2T-box transcription factor 2. (693 aa)
NR3C2Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). (993 aa)
SIX3Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
LHX4LIM homeobox 4. (533 aa)
GSCHomeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (548 aa)
HESX1Homeobox protein ANF-1; May be involved in the early patterning of the most anterior region of the main embryonic body axis. (210 aa)
TMEM108Transmembrane protein 108. (476 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
LOC428505SUN domain-containing protein. (246 aa)
BCANBrevican. (968 aa)
MCPH1Uncharacterized protein. (589 aa)
FEZ1Fasciculation and elongation protein zeta 1. (393 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
RFX4Regulatory factor X4. (743 aa)
DIXDC1DIX domain containing 1. (689 aa)
SUN1Sad1 and UNC84 domain containing 1. (906 aa)
GDF7Growth differentiation factor 7. (400 aa)
LOC770839SUN domain-containing protein. (306 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa)
ENSGALP00000066137Uncharacterized protein. (168 aa)
JAKMIP3Janus kinase and microtubule interacting protein 3. (869 aa)
LDLRUncharacterized protein. (302 aa)
TAL2TAL bHLH transcription factor 2. (117 aa)
EMX2Empty spiracles homeobox 2. (336 aa)
TOXThymocyte selection associated high mobility group box. (525 aa)
CEP120Centrosomal protein 120. (1006 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
TSC1Uncharacterized protein. (275 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2523 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
ENSGALP00000068920SUN domain-containing protein 3-like isoform X1. (182 aa)
NTRK2BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] (842 aa)
AKNAUncharacterized protein. (1246 aa)
RPGRIP1LRPGRIP1 like. (1273 aa)
DCLK1Uncharacterized protein. (740 aa)
MGARPMitochondria localized glutamic acid rich protein. (244 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
FYNTyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. (589 aa)
ENSGALP00000069955Uncharacterized protein. (496 aa)
FBXO45F-box protein 45. (107 aa)
HSD3B13Beta_HSD domain-containing protein. (484 aa)
ENSGALP00000070347Uncharacterized protein. (229 aa)
ENSGALP00000070762Homeobox domain-containing protein. (160 aa)
ENSGALP00000070978XRCC1_N domain-containing protein. (182 aa)
SZT2Uncharacterized protein. (3775 aa)
LOC107050371Uncharacterized protein. (1015 aa)
NF2LFERM domain-containing protein. (648 aa)
POU3F1POU domain protein. (374 aa)
LOC776146SUN domain-containing protein. (275 aa)
OTX1Orthodenticle homeobox 1. (335 aa)
BTG2BTG anti-proliferation factor 2. (164 aa)
STILSTIL centriolar assembly protein. (1330 aa)
SALL3Uncharacterized protein. (1333 aa)
LEF1HMG box domain-containing protein. (412 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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