STRINGSTRING
CREB3L1 CREB3L1 DNAJC10 DNAJC10 EIF2AK2 EIF2AK2 EP300 EP300 CREB3L2 CREB3L2 WFS1 WFS1 EIF2AK3 EIF2AK3 ATF4 ATF4 SELENOS SELENOS TBL2 TBL2 ATF6 ATF6 CDK5RAP3 CDK5RAP3 EIF2S1 EIF2S1 YOD1 YOD1 DDIT3 DDIT3 RHBDD2 RHBDD2 SERP1 SERP1 BHLHA15 BHLHA15 ENSGALP00000051793 ENSGALP00000051793 QRICH1 QRICH1 DERL2 DERL2 DERL3 DERL3 TMED2 TMED2 ENSGALP00000070665 ENSGALP00000070665 DERL1 DERL1 TMTC4 TMTC4 HERPUD2 HERPUD2 NFE2L2 NFE2L2 ATF3 ATF3 CREB3 CREB3 PTPN1 PTPN1 ERN1 ERN1 XBP1 XBP1 PARP16 PARP16 VAPB VAPB ERLEC1 ERLEC1 CREB3L3 CREB3L3 HERPUD1 HERPUD1 HSPA5 HSPA5 ERMP1 ERMP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3L1cAMP responsive element binding protein 3 like 1. (506 aa)
DNAJC10DnaJ heat shock protein family (Hsp40) member C10. (797 aa)
EIF2AK2Uncharacterized protein. (550 aa)
EP300E1A binding protein p300. (2450 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
ATF4ATF4. (354 aa)
SELENOSUncharacterized protein. (207 aa)
TBL2Transducin beta like 2. (279 aa)
ATF6Activating transcription factor 6. (671 aa)
CDK5RAP3Uncharacterized protein. (619 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa)
YOD1Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (346 aa)
DDIT3C/EBP-like protein. (155 aa)
RHBDD2Rhomboid domain-containing protein. (375 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
BHLHA15Basic helix-loop-helix family member a15. (166 aa)
ENSGALP00000051793Uncharacterized protein. (360 aa)
QRICH1DUF3504 domain-containing protein. (773 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa)
TMED2GOLD domain-containing protein. (208 aa)
ENSGALP00000070665Nuclear factor, erythroid 2. (326 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (826 aa)
HERPUD2HERPUD family member 2. (436 aa)
NFE2L2BZIP domain-containing protein. (593 aa)
ATF3Activating transcription factor 3. (181 aa)
CREB3cAMP responsive element binding protein 3. (390 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). (475 aa)
ERN1Uncharacterized protein. (968 aa)
XBP1BZIP domain-containing protein. (372 aa)
PARP16Poly [ADP-ribose] polymerase. (328 aa)
VAPBMSP domain-containing protein. (243 aa)
ERLEC1Endoplasmic reticulum lectin 1. (452 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
ERMP1Endoplasmic reticulum metallopeptidase 1. (680 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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