STRINGSTRING
HNF1A HNF1A NKX3-2 NKX3-2 DNAAF1 DNAAF1 HNF1B HNF1B CCDC40 CCDC40 NEUROD1 NEUROD1 PROX1 PROX1 SRP54 SRP54 SELENOT SELENOT NKX6-2 NKX6-2 WLS WLS GIP GIP IHH IHH BMP6 BMP6 DLL1 DLL1 PCSK1 PCSK1 RFX6 RFX6 CDH2 CDH2 WFS1 WFS1 EIF2AK3 EIF2AK3 ANXA1 ANXA1 SOX9 SOX9 PTF1A PTF1A ISL1 ISL1 CTNNB1 CTNNB1 CDH15 CDH15 SMO SMO PDX1 PDX1 BAK1 BAK1 MNX1 MNX1 NR5A2 NR5A2 NKX6-1 NKX6-1 IL6R IL6R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HNF1AHepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator. Belongs to the HNF1 homeobox family. (634 aa)
NKX3-2Homeobox domain-containing protein. (275 aa)
DNAAF1Dynein assembly factor 1, axonemal. (516 aa)
HNF1BHNF1 homeobox B. (531 aa)
CCDC40Coiled-coil domain containing 40. (931 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
PROX1Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
SELENOTThioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. Selenoprotein T subfamily. (199 aa)
NKX6-2Homeobox domain-containing protein. (364 aa)
WLSProtein wntless homolog; May play an essential role in Wnt signaling pathway. May be required for Wnt-dependent patterning processes (By similarity). Belongs to the wntless family. (541 aa)
GIPGLUCAGON domain-containing protein. (139 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
BMP6Bone morphogenetic protein 6. (434 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
RFX6Regulatory factor X6. (916 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
PTF1APancreas associated transcription factor 1a. (275 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
CTNNB1Uncharacterized protein. (781 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
PDX1Homeobox domain-containing protein. (259 aa)
BAK1Uncharacterized protein. (216 aa)
MNX1Homeobox domain-containing protein. (348 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2; Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism (By similarity). Activates the transcription of CYP2C38 (By similarity). (541 aa)
NKX6-1NK6 homeobox 1. (272 aa)
IL6RUncharacterized protein. (445 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.