STRINGSTRING
HERPUD1 HERPUD1 RC3H2 RC3H2 CALCOCO2 CALCOCO2 C9orf72 C9orf72 POLR2D POLR2D PLEKHN1 PLEKHN1 NPRL2 NPRL2 PATL2 PATL2 CNOT1 CNOT1 SIRT1 SIRT1 BECN1 BECN1 PARN PARN UPF1 UPF1 LSM1 LSM1 E1C066_CHICK E1C066_CHICK P2RX7 P2RX7 SH3BP4 SH3BP4 PLEKHF1 PLEKHF1 SMURF1 SMURF1 ZER1 ZER1 ULK2 ULK2 MKRN2 MKRN2 ZSWIM8 ZSWIM8 KLHL40 KLHL40 TSC2 TSC2 SESN2-2 SESN2-2 PLK1 PLK1 ZC3H18 ZC3H18 FAM122A FAM122A DET1 DET1 DEPDC5 DEPDC5 EIF4ENIF1 EIF4ENIF1 APOA1 APOA1 DAGLB DAGLB HSPB8 HSPB8 DIS3L2 DIS3L2 PRR5L PRR5L FBXW8 FBXW8 PSMD10 PSMD10 CAV3 CAV3 TPCN1 TPCN1 BAG3 BAG3 RAB3GAP2 RAB3GAP2 SH3RF1 SH3RF1 IFNG IFNG CDC20 CDC20 SOCS5 SOCS5 CNOT2 CNOT2 CNOT6L CNOT6L BNIP3 BNIP3 NRDC NRDC TUT4 TUT4 ZYG11A ZYG11A PRKAA2 PRKAA2 PNLDC1 PNLDC1 BBS7 BBS7 METTL14 METTL14 TNRC6B TNRC6B SNX4 SNX4 DTX3L DTX3L RAB3GAP1 RAB3GAP1 FBXO7 FBXO7 RNF144B RNF144B RBM24 RBM24 CNOT7 CNOT7 SNX9 SNX9 ENPP7 ENPP7 KDR KDR USP5 USP5 PNPLA2 PNPLA2 PRKAA1 PRKAA1 METTL16 METTL16 CLUL1 CLUL1 SNX18 SNX18 ZBTB20 ZBTB20 RB1CC1 RB1CC1 FOXO3 FOXO3 TRIM14 TRIM14 UFL1 UFL1 HTT HTT SNX30 SNX30 DDRGK1 DDRGK1 GCLC GCLC RNF19AL RNF19AL PTK2B PTK2B HTR2A HTR2A EXOSC8 EXOSC8 LOC419074 LOC419074 EPM2A EPM2A SVIP SVIP ZCCHC6 ZCCHC6 PRXL2C PRXL2C FZR1 FZR1 APP APP TRIB2 TRIB2 EXOSC9 EXOSC9 AMBRA1 AMBRA1 RCHY1 RCHY1 SMCR8 SMCR8 SUPV3L1 SUPV3L1 ARIH2 ARIH2 RNF152 RNF152 RNF144A RNF144A NANOS1 NANOS1 CAV1 CAV1 AGO2 AGO2 ATF6 ATF6 YTHDF3 YTHDF3 VPS13D VPS13D TMEM59 TMEM59 WAC WAC FYCO1 FYCO1 SIRT2 SIRT2 TNRC6A TNRC6A NOCT NOCT CSNK1D CSNK1D TFEB TFEB YTHDF1 YTHDF1 ZFP36L2 ZFP36L2 EXOSC7 EXOSC7 SAMD4B SAMD4B MLH1 MLH1 CNOT6 CNOT6 RIPK2 RIPK2 FLCN FLCN ZC3H12A ZC3H12A RNF19A RNF19A PINK1 PINK1 MLXIPL MLXIPL PAN3 PAN3 HSPBP1 HSPBP1 DCP2 DCP2 SESN1 SESN1 LRSAM1 LRSAM1 DISC1 DISC1 TMEM173 TMEM173 SPTLC1 SPTLC1 SESN3 SESN3 TP53INP2 TP53INP2 AXIN1 AXIN1 PNPT1 PNPT1 RIDA RIDA ENSGALP00000073564 ENSGALP00000073564 TPCN3 TPCN3 COP1 COP1 GPLD1 GPLD1 BTG2 BTG2 B9D2 B9D2 DAB2 DAB2 NUB1 NUB1 GPSM1 GPSM1 DDA1 DDA1 PRKN PRKN RIPK3 RIPK3 PDE12 PDE12 PCSK9 PCSK9 DCP1B DCP1B BCL2L11 BCL2L11 WDR24 WDR24 DND1 DND1 TNRC6C TNRC6C PACSIN3 PACSIN3 LARP1 LARP1 CDC20B CDC20B PSEN1 PSEN1 RC3H1 RC3H1 RNF180 RNF180 RNF217 RNF217 PNPLA3 PNPLA3 TSC1 TSC1 IL6 IL6 FBXW9 FBXW9 EXOSC3 EXOSC3 RNF19B RNF19B GSK3B GSK3B SH3RF3 SH3RF3 SH3D19 SH3D19 SCOC SCOC CSNK1A1 CSNK1A1 ENSGALP00000065087 ENSGALP00000065087 ATG101 ATG101 SOCS4 SOCS4 EXOSC2 EXOSC2 CNOT8 CNOT8 SIRT6 SIRT6 DCN DCN CCDC90B CCDC90B SH3RF2 SH3RF2 LOC107051192 LOC107051192 METTL3 METTL3 ANKIB1 ANKIB1 ZFP36L1 ZFP36L1 FTO FTO GTPBP1 GTPBP1 SAMD4A SAMD4A NOP53 NOP53 TRIM67 TRIM67 GIGYF2 GIGYF2 SMAD7B SMAD7B FOXO1 FOXO1 PAN2 PAN2 TNFRSF1B TNFRSF1B NOD1 NOD1 TP53INP1 TP53INP1 TNFRSF8 TNFRSF8 PUM1 PUM1 ITCH ITCH NPRL3 NPRL3 DCP1A DCP1A AXIN2 AXIN2 SMAD7 SMAD7 WIPI1 WIPI1 FBXO22 FBXO22 TRIM8 TRIM8 GRSF1 GRSF1 ABHD4 ABHD4 RNF14 RNF14 SESN2 SESN2 ROCK1 ROCK1 PATL1 PATL1 CSNK1E CSNK1E YTHDF2 YTHDF2 LRRK2 LRRK2 ABCD2 ABCD2 DCPS DCPS DHX36 DHX36 ARIH1 ARIH1 ULK1 ULK1 TRIB1 TRIB1 FBXW7 FBXW7 SNX33 SNX33 RNF139 RNF139 IL1B IL1B SNX7 SNX7 SGTA SGTA AGO3 AGO3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
CALCOCO2SKICH domain-containing protein. (357 aa)
C9orf72C9orf72-SMCR8 complex subunit. (336 aa)
POLR2DRPOL4c domain-containing protein. (142 aa)
PLEKHN1Pleckstrin homology domain containing N1. (605 aa)
NPRL2Uncharacterized protein. (378 aa)
PATL2PAT1 homolog 2. (781 aa)
CNOT1Uncharacterized protein. (2376 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
BECN1Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa)
PARNR3H domain-containing protein. (635 aa)
UPF1UPF1 RNA helicase and ATPase. (1117 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (133 aa)
E1C066_CHICKUncharacterized protein. (258 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
SH3BP4SH3 domain binding protein 4. (964 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (273 aa)
SMURF1E3 ubiquitin-protein ligase. (744 aa)
ZER1Zyg-11 related cell cycle regulator. (766 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1001 aa)
MKRN2Uncharacterized protein. (417 aa)
ZSWIM8SWIM-type domain-containing protein. (1833 aa)
KLHL40Kelch like family member 40. (587 aa)
TSC2TSC complex subunit 2. (1872 aa)
SESN2-2Uncharacterized protein. (450 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
ZC3H18Zinc finger CCCH-type containing 18. (902 aa)
FAM122AProtein FAM122A; Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). (284 aa)
DET1Uncharacterized protein. (551 aa)
DEPDC5DEP domain-containing protein. (1592 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (990 aa)
APOA1Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa)
DAGLBLipase_3 domain-containing protein. (667 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (197 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1128 aa)
PRR5LProline rich 5 like. (366 aa)
FBXW8F-box and WD repeat domain containing 8. (582 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TPCN1Two pore segment channel 1. (817 aa)
BAG3BCL2 associated athanogene 3. (560 aa)
RAB3GAP2Uncharacterized protein. (1382 aa)
SH3RF1SH3 domain containing ring finger 1. (872 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (507 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CNOT2NOT2_3_5 domain-containing protein. (520 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (607 aa)
BNIP3BCL2 interacting protein 3. (155 aa)
NRDCUncharacterized protein; Belongs to the peptidase M16 family. (1159 aa)
TUT4Terminal uridylyl transferase 4. (1539 aa)
ZYG11AZyg-11 family member B, cell cycle regulator. (735 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (509 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (716 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. (459 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1805 aa)
SNX4Sorting nexin 4. (435 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (737 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1014 aa)
FBXO7F-box domain-containing protein. (526 aa)
RNF144BRBR-type E3 ubiquitin transferase. (302 aa)
RBM24RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (225 aa)
CNOT7CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa)
SNX9Sorting nexin. (600 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (444 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
USP5Ubiquitin carboxyl-terminal hydrolase. (832 aa)
PNPLA2PNPLA2/ATGL. (483 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
METTL16RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] (557 aa)
CLUL1Clusterin; Belongs to the clusterin family. (461 aa)
SNX18Sorting nexin. (601 aa)
ZBTB20Zinc finger and BTB domain containing 20. (669 aa)
RB1CC1RB1 inducible coiled-coil 1. (1598 aa)
FOXO3Forkhead box O3. (660 aa)
TRIM14Uncharacterized protein. (433 aa)
UFL1E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (789 aa)
HTTHuntingtin. (3095 aa)
SNX30Sorting nexin family member 30. (438 aa)
DDRGK1DDRGK domain containing 1. (221 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
RNF19ALRBR-type E3 ubiquitin transferase. (525 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (992 aa)
HTR2A5-hydroxytryptamine (Serotonin) receptor 2A. (468 aa)
EXOSC8Exosome component 8. (283 aa)
LOC419074Uncharacterized protein. (765 aa)
EPM2ALaforin. (319 aa)
SVIPUncharacterized protein. (80 aa)
ZCCHC6Uncharacterized protein. (1538 aa)
PRXL2CPeroxiredoxin like 2C. (222 aa)
FZR1WD_REPEATS_REGION domain-containing protein. (493 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
TRIB2TRB2 protein. (343 aa)
EXOSC9Polymyositis/scleroderma autoantigen 1. (440 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1. (256 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
SUPV3L1ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation o [...] (794 aa)
ARIH2RBR-type E3 ubiquitin transferase. (490 aa)
RNF152E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation; Belongs to the RNF152 family. (203 aa)
RNF144ARBR-type E3 ubiquitin transferase. (292 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (254 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (864 aa)
ATF6Activating transcription factor 6. (671 aa)
YTHDF3YTH domain-containing protein. (593 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4371 aa)
TMEM59Uncharacterized protein. (325 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
FYCO1Uncharacterized protein. (1540 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1720 aa)
NOCTEndo/exonuclease/phosphatase domain-containing protein. (386 aa)
CSNK1DProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
TFEBBHLH domain-containing protein. (493 aa)
YTHDF1YTH domain-containing protein. (561 aa)
ZFP36L2Uncharacterized protein. (489 aa)
EXOSC7Uncharacterized protein. (291 aa)
SAMD4BSterile alpha motif domain containing 4B. (666 aa)
MLH1DNA mismatch repair protein MLH1. (757 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (681 aa)
RNF19ARBR-type E3 ubiquitin transferase. (820 aa)
PINK1PTEN induced kinase 1. (364 aa)
MLXIPLBHLH domain-containing protein. (895 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (687 aa)
HSPBP1Uncharacterized protein. (330 aa)
DCP2Decapping mRNA 2. (416 aa)
SESN1Sestrin 1. (564 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (728 aa)
DISC1DISC1 scaffold protein. (856 aa)
TMEM173Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (By similarity). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus [...] (379 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (476 aa)
SESN3Sestrin 3. (492 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (213 aa)
AXIN1Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (896 aa)
RIDAReactive intermediate imine deaminase A homolog. (286 aa)
ENSGALP00000073564Uncharacterized protein. (243 aa)
TPCN3Uncharacterized protein. (783 aa)
COP1COP1 E3 ubiquitin ligase. (723 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
BTG2BTG anti-proliferation factor 2. (164 aa)
B9D2RNase_PH domain-containing protein. (594 aa)
DAB2DAB adaptor protein 2. (715 aa)
NUB1Uncharacterized protein. (611 aa)
GPSM1G protein signaling modulator 1. (666 aa)
DDA1DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (166 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
RIPK3Uncharacterized protein. (424 aa)
PDE12Phosphodiesterase 12. (584 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa)
DCP1BDecapping mRNA 1B. (606 aa)
BCL2L11BCL2 like 11. (179 aa)
WDR24GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (789 aa)
DND1DND microRNA-mediated repression inhibitor 1. (405 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1797 aa)
PACSIN3Uncharacterized protein. (458 aa)
LARP1La ribonucleoprotein domain family member 1. (1046 aa)
CDC20BCell division cycle 20B. (403 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
RC3H1Ring finger and CCCH-type domains 1. (1114 aa)
RNF180Ring finger protein 180. (609 aa)
RNF217RBR-type E3 ubiquitin transferase. (453 aa)
PNPLA3Patatin like phospholipase domain containing 3. (543 aa)
TSC1Uncharacterized protein. (275 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
FBXW9F-box domain-containing protein. (337 aa)
EXOSC3KH_dom_type_1 domain-containing protein. (288 aa)
RNF19BRing finger protein 19B. (406 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
SH3RF3SH3 domain containing ring finger 3. (736 aa)
SH3D19SH3 domain containing 19. (1123 aa)
SCOCUncharacterized protein. (120 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly. (370 aa)
ENSGALP00000065087Uncharacterized protein. (76 aa)
ATG101Autophagy related 101. (236 aa)
SOCS4Uncharacterized protein. (436 aa)
EXOSC2S1 domain-containing protein. (294 aa)
CNOT8Uncharacterized protein. (292 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
CCDC90BCoiled-coil domain containing 90B. (261 aa)
SH3RF2SH3 domain containing ring finger 2. (644 aa)
LOC107051192RanBP2-type domain-containing protein. (1255 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (548 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1064 aa)
ZFP36L1Zinc finger protein 36 C3H1 type-like 1 protein. (335 aa)
FTOFTO_NTD domain-containing protein. (565 aa)
GTPBP1Tr-type G domain-containing protein. (682 aa)
SAMD4ASterile alpha motif domain containing 4A. (705 aa)
NOP53NOP53 ribosome biogenesis factor. (598 aa)
TRIM67Tripartite motif containing 67. (717 aa)
GIGYF2GYF domain-containing protein. (1278 aa)
SMAD7BMothers against decapentaplegic homolog. (388 aa)
FOXO1Fork-head domain-containing protein. (727 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1439 aa)
TNFRSF1BUncharacterized protein. (462 aa)
NOD1Uncharacterized protein. (951 aa)
TP53INP1Uncharacterized protein. (237 aa)
TNFRSF8TNFR-Cys domain-containing protein. (467 aa)
PUM1Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. (1189 aa)
ITCHE3 ubiquitin-protein ligase. (878 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
DCP1ADecapping mRNA 1A. (582 aa)
AXIN2Uncharacterized protein. (837 aa)
SMAD7Mothers against decapentaplegic homolog. (388 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (508 aa)
FBXO22FIST_C domain-containing protein. (393 aa)
TRIM8RING-type domain-containing protein. (551 aa)
GRSF1G-rich RNA sequence binding factor 1. (467 aa)
ABHD4AB hydrolase-1 domain-containing protein. (385 aa)
RNF14RBR-type E3 ubiquitin transferase. (470 aa)
SESN2Uncharacterized protein. (474 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (754 aa)
CSNK1ECasein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity). (416 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (645 aa)
LRRK2Uncharacterized protein. (2557 aa)
ABCD2Uncharacterized protein. (730 aa)
DCPSDecapping enzyme, scavenger. (230 aa)
DHX36DEAH-box helicase 36. (987 aa)
ARIH1RBR-type E3 ubiquitin transferase. (552 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1081 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
FBXW7Uncharacterized protein. (586 aa)
SNX33Sorting nexin. (554 aa)
RNF139RING-type domain-containing protein. (677 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
SNX7Sorting nexin 7. (445 aa)
SGTATPR_REGION domain-containing protein. (312 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity. (860 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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