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HERPUD1 | Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa) | ||||
RC3H2 | Ring finger and CCCH-type domains 2. (1191 aa) | ||||
CALCOCO2 | SKICH domain-containing protein. (357 aa) | ||||
C9orf72 | C9orf72-SMCR8 complex subunit. (336 aa) | ||||
POLR2D | RPOL4c domain-containing protein. (142 aa) | ||||
PLEKHN1 | Pleckstrin homology domain containing N1. (605 aa) | ||||
NPRL2 | Uncharacterized protein. (378 aa) | ||||
PATL2 | PAT1 homolog 2. (781 aa) | ||||
CNOT1 | Uncharacterized protein. (2376 aa) | ||||
SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) | ||||
BECN1 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa) | ||||
PARN | R3H domain-containing protein. (635 aa) | ||||
UPF1 | UPF1 RNA helicase and ATPase. (1117 aa) | ||||
LSM1 | U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (133 aa) | ||||
E1C066_CHICK | Uncharacterized protein. (258 aa) | ||||
P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa) | ||||
SH3BP4 | SH3 domain binding protein 4. (964 aa) | ||||
PLEKHF1 | Pleckstrin homology and FYVE domain containing 1. (273 aa) | ||||
SMURF1 | E3 ubiquitin-protein ligase. (744 aa) | ||||
ZER1 | Zyg-11 related cell cycle regulator. (766 aa) | ||||
ULK2 | Unc-51 like autophagy activating kinase 2. (1001 aa) | ||||
MKRN2 | Uncharacterized protein. (417 aa) | ||||
ZSWIM8 | SWIM-type domain-containing protein. (1833 aa) | ||||
KLHL40 | Kelch like family member 40. (587 aa) | ||||
TSC2 | TSC complex subunit 2. (1872 aa) | ||||
SESN2-2 | Uncharacterized protein. (450 aa) | ||||
PLK1 | Serine/threonine-protein kinase PLK. (595 aa) | ||||
ZC3H18 | Zinc finger CCCH-type containing 18. (902 aa) | ||||
FAM122A | Protein FAM122A; Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). (284 aa) | ||||
DET1 | Uncharacterized protein. (551 aa) | ||||
DEPDC5 | DEP domain-containing protein. (1592 aa) | ||||
EIF4ENIF1 | Eukaryotic translation initiation factor 4E nuclear import factor 1. (990 aa) | ||||
APOA1 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa) | ||||
DAGLB | Lipase_3 domain-containing protein. (667 aa) | ||||
HSPB8 | Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (197 aa) | ||||
DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1128 aa) | ||||
PRR5L | Proline rich 5 like. (366 aa) | ||||
FBXW8 | F-box and WD repeat domain containing 8. (582 aa) | ||||
PSMD10 | ANK_REP_REGION domain-containing protein. (226 aa) | ||||
CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) | ||||
TPCN1 | Two pore segment channel 1. (817 aa) | ||||
BAG3 | BCL2 associated athanogene 3. (560 aa) | ||||
RAB3GAP2 | Uncharacterized protein. (1382 aa) | ||||
SH3RF1 | SH3 domain containing ring finger 1. (872 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa) | ||||
CDC20 | WD_REPEATS_REGION domain-containing protein. (507 aa) | ||||
SOCS5 | Suppressor of cytokine signaling 5. (536 aa) | ||||
CNOT2 | NOT2_3_5 domain-containing protein. (520 aa) | ||||
CNOT6L | CCR4-NOT transcription complex subunit 6 like. (607 aa) | ||||
BNIP3 | BCL2 interacting protein 3. (155 aa) | ||||
NRDC | Uncharacterized protein; Belongs to the peptidase M16 family. (1159 aa) | ||||
TUT4 | Terminal uridylyl transferase 4. (1539 aa) | ||||
ZYG11A | Zyg-11 family member B, cell cycle regulator. (735 aa) | ||||
PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) | ||||
PNLDC1 | PARN like, ribonuclease domain containing 1. (509 aa) | ||||
BBS7 | Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (716 aa) | ||||
METTL14 | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. (459 aa) | ||||
TNRC6B | Trinucleotide repeat containing adaptor 6B. (1805 aa) | ||||
SNX4 | Sorting nexin 4. (435 aa) | ||||
DTX3L | Deltex E3 ubiquitin ligase 3L. (737 aa) | ||||
RAB3GAP1 | RAB3 GTPase activating protein catalytic subunit 1. (1014 aa) | ||||
FBXO7 | F-box domain-containing protein. (526 aa) | ||||
RNF144B | RBR-type E3 ubiquitin transferase. (302 aa) | ||||
RBM24 | RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (225 aa) | ||||
CNOT7 | CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa) | ||||
SNX9 | Sorting nexin. (600 aa) | ||||
ENPP7 | Ectonucleotide pyrophosphatase/phosphodiesterase 7. (444 aa) | ||||
KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa) | ||||
USP5 | Ubiquitin carboxyl-terminal hydrolase. (832 aa) | ||||
PNPLA2 | PNPLA2/ATGL. (483 aa) | ||||
PRKAA1 | Non-specific serine/threonine protein kinase. (560 aa) | ||||
METTL16 | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] (557 aa) | ||||
CLUL1 | Clusterin; Belongs to the clusterin family. (461 aa) | ||||
SNX18 | Sorting nexin. (601 aa) | ||||
ZBTB20 | Zinc finger and BTB domain containing 20. (669 aa) | ||||
RB1CC1 | RB1 inducible coiled-coil 1. (1598 aa) | ||||
FOXO3 | Forkhead box O3. (660 aa) | ||||
TRIM14 | Uncharacterized protein. (433 aa) | ||||
UFL1 | E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (789 aa) | ||||
HTT | Huntingtin. (3095 aa) | ||||
SNX30 | Sorting nexin family member 30. (438 aa) | ||||
DDRGK1 | DDRGK domain containing 1. (221 aa) | ||||
GCLC | Glutamate-cysteine ligase catalytic subunit. (636 aa) | ||||
RNF19AL | RBR-type E3 ubiquitin transferase. (525 aa) | ||||
PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (992 aa) | ||||
HTR2A | 5-hydroxytryptamine (Serotonin) receptor 2A. (468 aa) | ||||
EXOSC8 | Exosome component 8. (283 aa) | ||||
LOC419074 | Uncharacterized protein. (765 aa) | ||||
EPM2A | Laforin. (319 aa) | ||||
SVIP | Uncharacterized protein. (80 aa) | ||||
ZCCHC6 | Uncharacterized protein. (1538 aa) | ||||
PRXL2C | Peroxiredoxin like 2C. (222 aa) | ||||
FZR1 | WD_REPEATS_REGION domain-containing protein. (493 aa) | ||||
APP | BPTI/Kunitz inhibitor domain-containing protein. (751 aa) | ||||
TRIB2 | TRB2 protein. (343 aa) | ||||
EXOSC9 | Polymyositis/scleroderma autoantigen 1. (440 aa) | ||||
AMBRA1 | Autophagy and beclin 1 regulator 1. (872 aa) | ||||
RCHY1 | RING finger and CHY zinc finger domain-containing protein 1. (256 aa) | ||||
SMCR8 | SMCR8-C9orf72 complex subunit. (935 aa) | ||||
SUPV3L1 | ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation o [...] (794 aa) | ||||
ARIH2 | RBR-type E3 ubiquitin transferase. (490 aa) | ||||
RNF152 | E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation; Belongs to the RNF152 family. (203 aa) | ||||
RNF144A | RBR-type E3 ubiquitin transferase. (292 aa) | ||||
NANOS1 | Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (254 aa) | ||||
CAV1 | Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa) | ||||
AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (864 aa) | ||||
ATF6 | Activating transcription factor 6. (671 aa) | ||||
YTHDF3 | YTH domain-containing protein. (593 aa) | ||||
VPS13D | Vacuolar protein sorting 13 homolog D. (4371 aa) | ||||
TMEM59 | Uncharacterized protein. (325 aa) | ||||
WAC | WW domain containing adaptor with coiled-coil. (646 aa) | ||||
FYCO1 | Uncharacterized protein. (1540 aa) | ||||
SIRT2 | Deacetylase sirtuin-type domain-containing protein. (485 aa) | ||||
TNRC6A | Trinucleotide repeat containing adaptor 6A. (1720 aa) | ||||
NOCT | Endo/exonuclease/phosphatase domain-containing protein. (386 aa) | ||||
CSNK1D | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa) | ||||
TFEB | BHLH domain-containing protein. (493 aa) | ||||
YTHDF1 | YTH domain-containing protein. (561 aa) | ||||
ZFP36L2 | Uncharacterized protein. (489 aa) | ||||
EXOSC7 | Uncharacterized protein. (291 aa) | ||||
SAMD4B | Sterile alpha motif domain containing 4B. (666 aa) | ||||
MLH1 | DNA mismatch repair protein MLH1. (757 aa) | ||||
CNOT6 | CCR4-NOT transcription complex subunit 6. (557 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa) | ||||
FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (579 aa) | ||||
ZC3H12A | Zinc finger CCCH-type containing 12A. (681 aa) | ||||
RNF19A | RBR-type E3 ubiquitin transferase. (820 aa) | ||||
PINK1 | PTEN induced kinase 1. (364 aa) | ||||
MLXIPL | BHLH domain-containing protein. (895 aa) | ||||
PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (687 aa) | ||||
HSPBP1 | Uncharacterized protein. (330 aa) | ||||
DCP2 | Decapping mRNA 2. (416 aa) | ||||
SESN1 | Sestrin 1. (564 aa) | ||||
LRSAM1 | Leucine rich repeat and sterile alpha motif containing 1. (728 aa) | ||||
DISC1 | DISC1 scaffold protein. (856 aa) | ||||
TMEM173 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (By similarity). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus [...] (379 aa) | ||||
SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (476 aa) | ||||
SESN3 | Sestrin 3. (492 aa) | ||||
TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (213 aa) | ||||
AXIN1 | Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa) | ||||
PNPT1 | Polyribonucleotide nucleotidyltransferase 1. (896 aa) | ||||
RIDA | Reactive intermediate imine deaminase A homolog. (286 aa) | ||||
ENSGALP00000073564 | Uncharacterized protein. (243 aa) | ||||
TPCN3 | Uncharacterized protein. (783 aa) | ||||
COP1 | COP1 E3 ubiquitin ligase. (723 aa) | ||||
GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (856 aa) | ||||
BTG2 | BTG anti-proliferation factor 2. (164 aa) | ||||
B9D2 | RNase_PH domain-containing protein. (594 aa) | ||||
DAB2 | DAB adaptor protein 2. (715 aa) | ||||
NUB1 | Uncharacterized protein. (611 aa) | ||||
GPSM1 | G protein signaling modulator 1. (666 aa) | ||||
DDA1 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (166 aa) | ||||
PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa) | ||||
RIPK3 | Uncharacterized protein. (424 aa) | ||||
PDE12 | Phosphodiesterase 12. (584 aa) | ||||
PCSK9 | Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa) | ||||
DCP1B | Decapping mRNA 1B. (606 aa) | ||||
BCL2L11 | BCL2 like 11. (179 aa) | ||||
WDR24 | GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (789 aa) | ||||
DND1 | DND microRNA-mediated repression inhibitor 1. (405 aa) | ||||
TNRC6C | Trinucleotide repeat containing adaptor 6C. (1797 aa) | ||||
PACSIN3 | Uncharacterized protein. (458 aa) | ||||
LARP1 | La ribonucleoprotein domain family member 1. (1046 aa) | ||||
CDC20B | Cell division cycle 20B. (403 aa) | ||||
PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa) | ||||
RC3H1 | Ring finger and CCCH-type domains 1. (1114 aa) | ||||
RNF180 | Ring finger protein 180. (609 aa) | ||||
RNF217 | RBR-type E3 ubiquitin transferase. (453 aa) | ||||
PNPLA3 | Patatin like phospholipase domain containing 3. (543 aa) | ||||
TSC1 | Uncharacterized protein. (275 aa) | ||||
IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa) | ||||
FBXW9 | F-box domain-containing protein. (337 aa) | ||||
EXOSC3 | KH_dom_type_1 domain-containing protein. (288 aa) | ||||
RNF19B | Ring finger protein 19B. (406 aa) | ||||
GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) | ||||
SH3RF3 | SH3 domain containing ring finger 3. (736 aa) | ||||
SH3D19 | SH3 domain containing 19. (1123 aa) | ||||
SCOC | Uncharacterized protein. (120 aa) | ||||
CSNK1A1 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly. (370 aa) | ||||
ENSGALP00000065087 | Uncharacterized protein. (76 aa) | ||||
ATG101 | Autophagy related 101. (236 aa) | ||||
SOCS4 | Uncharacterized protein. (436 aa) | ||||
EXOSC2 | S1 domain-containing protein. (294 aa) | ||||
CNOT8 | Uncharacterized protein. (292 aa) | ||||
SIRT6 | Deacetylase sirtuin-type domain-containing protein. (378 aa) | ||||
DCN | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa) | ||||
CCDC90B | Coiled-coil domain containing 90B. (261 aa) | ||||
SH3RF2 | SH3 domain containing ring finger 2. (644 aa) | ||||
LOC107051192 | RanBP2-type domain-containing protein. (1255 aa) | ||||
METTL3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (548 aa) | ||||
ANKIB1 | RBR-type E3 ubiquitin transferase. (1064 aa) | ||||
ZFP36L1 | Zinc finger protein 36 C3H1 type-like 1 protein. (335 aa) | ||||
FTO | FTO_NTD domain-containing protein. (565 aa) | ||||
GTPBP1 | Tr-type G domain-containing protein. (682 aa) | ||||
SAMD4A | Sterile alpha motif domain containing 4A. (705 aa) | ||||
NOP53 | NOP53 ribosome biogenesis factor. (598 aa) | ||||
TRIM67 | Tripartite motif containing 67. (717 aa) | ||||
GIGYF2 | GYF domain-containing protein. (1278 aa) | ||||
SMAD7B | Mothers against decapentaplegic homolog. (388 aa) | ||||
FOXO1 | Fork-head domain-containing protein. (727 aa) | ||||
PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1439 aa) | ||||
TNFRSF1B | Uncharacterized protein. (462 aa) | ||||
NOD1 | Uncharacterized protein. (951 aa) | ||||
TP53INP1 | Uncharacterized protein. (237 aa) | ||||
TNFRSF8 | TNFR-Cys domain-containing protein. (467 aa) | ||||
PUM1 | Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. (1189 aa) | ||||
ITCH | E3 ubiquitin-protein ligase. (878 aa) | ||||
NPRL3 | NPR3 like, GATOR1 complex subunit. (582 aa) | ||||
DCP1A | Decapping mRNA 1A. (582 aa) | ||||
AXIN2 | Uncharacterized protein. (837 aa) | ||||
SMAD7 | Mothers against decapentaplegic homolog. (388 aa) | ||||
WIPI1 | WD repeat domain, phosphoinositide interacting 1. (508 aa) | ||||
FBXO22 | FIST_C domain-containing protein. (393 aa) | ||||
TRIM8 | RING-type domain-containing protein. (551 aa) | ||||
GRSF1 | G-rich RNA sequence binding factor 1. (467 aa) | ||||
ABHD4 | AB hydrolase-1 domain-containing protein. (385 aa) | ||||
RNF14 | RBR-type E3 ubiquitin transferase. (470 aa) | ||||
SESN2 | Uncharacterized protein. (474 aa) | ||||
ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa) | ||||
PATL1 | PAT1 homolog 1, processing body mRNA decay factor. (754 aa) | ||||
CSNK1E | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity). (416 aa) | ||||
YTHDF2 | YTH N6-methyladenosine RNA binding protein 2. (645 aa) | ||||
LRRK2 | Uncharacterized protein. (2557 aa) | ||||
ABCD2 | Uncharacterized protein. (730 aa) | ||||
DCPS | Decapping enzyme, scavenger. (230 aa) | ||||
DHX36 | DEAH-box helicase 36. (987 aa) | ||||
ARIH1 | RBR-type E3 ubiquitin transferase. (552 aa) | ||||
ULK1 | Unc-51 like autophagy activating kinase 1. (1081 aa) | ||||
TRIB1 | Tribbles pseudokinase 1. (372 aa) | ||||
FBXW7 | Uncharacterized protein. (586 aa) | ||||
SNX33 | Sorting nexin. (554 aa) | ||||
RNF139 | RING-type domain-containing protein. (677 aa) | ||||
IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) | ||||
SNX7 | Sorting nexin 7. (445 aa) | ||||
SGTA | TPR_REGION domain-containing protein. (312 aa) | ||||
AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity. (860 aa) |