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| | FBXL17 | F-box and leucine rich repeat protein 17. (442 aa) |
| | DCAF7 | WD_REPEATS_REGION domain-containing protein. (460 aa) |
| | KLHL12 | Kelch like family member 12. (565 aa) |
| | CDC27 | Uncharacterized protein. (833 aa) |
| | FBXL20 | F-box and leucine rich repeat protein 20. (436 aa) |
| | KLHL6 | BTB domain-containing protein. (610 aa) |
| | SPSB3 | SplA/ryanodine receptor domain and SOCS box containing 3. (389 aa) |
| | FBXL16 | Uncharacterized protein. (503 aa) |
| | DAW1 | Dynein assembly factor with WD repeats 1. (415 aa) |
| | TRPC4AP | Uncharacterized protein. (771 aa) |
| | FBXL8 | F-box domain-containing protein. (379 aa) |
| | SKP2 | F-box domain-containing protein. (520 aa) |
| | FBXO42 | F-box protein 42. (764 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (565 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (134 aa) |
| | CACYBP | Calcyclin binding protein. (221 aa) |
| | FBXL18 | F-box domain-containing protein. (711 aa) |
| | ZER1 | Zyg-11 related cell cycle regulator. (766 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) |
| | ZSWIM8 | SWIM-type domain-containing protein. (1833 aa) |
| | KCTD10 | Potassium channel tetramerization domain containing 10. (313 aa) |
| | KLHL40 | Kelch like family member 40. (587 aa) |
| | APPBP2 | TPR_REGION domain-containing protein. (586 aa) |
| | DCAF10 | DDB1 and CUL4 associated factor 10. (390 aa) |
| | FBXL15 | F-box and leucine rich repeat protein 15. (299 aa) |
| | DCAF12L2 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (427 aa) |
| | GLMN | Glomulin, FKBP associated protein. (628 aa) |
| | KLHL22 | BTB domain-containing protein. (638 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa) |
| | DET1 | Uncharacterized protein. (551 aa) |
| | KLHL25 | Kelch like family member 25. (589 aa) |
| | CDC23 | Cell division cycle 23. (595 aa) |
| | KCTD2 | BTB domain-containing protein. (332 aa) |
| | KLHDC10 | Kelch domain containing 10. (409 aa) |
| | FEM1C | Fem-1 homolog C. (617 aa) |
| | FBXW8 | F-box and WD repeat domain containing 8. (582 aa) |
| | DDB2 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1- CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1- CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV [...] (507 aa) |
| | CRBN | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (445 aa) |
| | COMMD1 | Copper metabolism domain containing 1. (215 aa) |
| | ANKRD9L | ANK_REP_REGION domain-containing protein. (293 aa) |
| | DCAF4L2 | WD_REPEATS_REGION domain-containing protein. (501 aa) |
| | DCAF5 | DDB1 and CUL4 associated factor 5. (959 aa) |
| | KLHL2 | BTB domain-containing protein. (599 aa) |
| | ASB4 | Ankyrin repeat and SOCS box containing 4. (425 aa) |
| | DTL | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (720 aa) |
| | CDC20 | WD_REPEATS_REGION domain-containing protein. (507 aa) |
| | FBXO33 | F-box protein 33. (526 aa) |
| | ZSWIM5 | Zinc finger SWIM-type containing 5. (1321 aa) |
| | ZYG11A | Zyg-11 family member B, cell cycle regulator. (735 aa) |
| | KLHL7 | Kelch-like protein 7; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity). (586 aa) |
| | KLHL8 | Kelch like family member 8. (617 aa) |
| | RBX1 | RING-type domain-containing protein. (108 aa) |
| | FBXO7 | F-box domain-containing protein. (526 aa) |
| | PDCD6 | Programmed cell death 6. (178 aa) |
| | GAN | Gigaxonin. (590 aa) |
| | FBXL5 | F-box and leucine rich repeat protein 5. (837 aa) |
| | ZSWIM6 | SWIM-type domain-containing protein. (1157 aa) |
| | ENC1 | Ectodermal-neural cortex 1. (589 aa) |
| | F1NU19_CHICK | WD_REPEATS_REGION domain-containing protein. (306 aa) |
| | FBXO9 | F-box domain-containing protein. (435 aa) |
| | KLHL34 | Kelch like family member 34. (595 aa) |
| | CDC16 | TPR_REGION domain-containing protein. (623 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (767 aa) |
| | KLHL42 | Kelch like family member 42. (503 aa) |
| | KLHL35 | Kelch like family member 35. (503 aa) |
| | FBXO48 | F-box protein 48. (155 aa) |
| | KLHDC2 | Uncharacterized protein. (407 aa) |
| | RNF7 | RING-type domain-containing protein. (114 aa) |
| | FZR1 | WD_REPEATS_REGION domain-containing protein. (493 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (872 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa) |
| | FEM1A | Fem-1 homolog A. (765 aa) |
| | ANKRD9 | Ankyrin repeat domain 9. (292 aa) |
| | USP47 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). (1376 aa) |
| | FEM1B | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity); Belongs to the fem-1 family. (627 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | LOC425795 | BTB domain-containing protein. (589 aa) |
| | LOC100859020 | Uncharacterized protein. (397 aa) |
| | FBXO15 | F-box protein 15. (473 aa) |
| | SPSB4 | SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa) |
| | FBXL4 | F-box and leucine rich repeat protein 4. (620 aa) |
| | FBXW5 | Uncharacterized protein. (588 aa) |
| | FBXW11 | Uncharacterized protein. (531 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (662 aa) |
| | LZTR1 | Leucine zipper like transcription regulator 1. (786 aa) |
| | FBXO32 | Uncharacterized protein. (355 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (793 aa) |
| | PEF1 | Penta-EF-hand domain containing 1. (223 aa) |
| | KLHL3 | Kelch like family member 3. (593 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (883 aa) |
| | DCAF17 | DDB1 and CUL4 associated factor 17. (544 aa) |
| | ANAPC4 | Anaphase promoting complex subunit 4. (838 aa) |
| | DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa) |
| | CCNF | Cyclin F; Belongs to the cyclin family. (750 aa) |
| | FBXL2 | F-box and leucine rich repeat protein 2. (436 aa) |
| | CUL2 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | FAM89A | Family with sequence similarity 89 member A. (136 aa) |
| | KLHL15 | Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. (604 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1505 aa) |
| | FBXO39 | F-box protein 39. (402 aa) |
| | FBXL7 | F-box and leucine rich repeat protein 7. (491 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (121 aa) |
| | KLHL21 | Kelch like family member 21. (600 aa) |
| | FBXO2 | F-box protein 2. (247 aa) |
| | TMEM183A | Uncharacterized protein. (368 aa) |
| | CACUL1 | Cullin domain-containing protein; Belongs to the cullin family. (377 aa) |
| | FBXO4 | F-box protein 4. (354 aa) |
| | ENSGALP00000055781 | Cullin_Nedd8 domain-containing protein. (146 aa) |
| | GSE1 | Gse1 coiled-coil protein. (1169 aa) |
| | FBXO44 | Uncharacterized protein. (304 aa) |
| | ANAPC13 | Uncharacterized protein. (74 aa) |
| | LOC100859602 | SWIM-type domain-containing protein. (1005 aa) |
| | KBTBD8 | Kelch repeat and BTB domain containing 8. (601 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). (613 aa) |
| | FBXL21 | F-box domain-containing protein. (437 aa) |
| | FBXL14 | F-box and leucine rich repeat protein 14. (400 aa) |
| | DCAF13 | DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). (566 aa) |
| | ENSGALP00000058556 | WD_REPEATS_REGION domain-containing protein. (410 aa) |
| | ENSGALP00000059206 | Uncharacterized protein. (64 aa) |
| | KLHDC1 | Kelch domain containing 1. (404 aa) |
| | FBXL13 | Uncharacterized protein. (439 aa) |
| | FBXO25 | F-box protein 25. (370 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | KCTD17 | Potassium channel tetramerization domain containing 17. (223 aa) |
| | ENSGALP00000065343 | F-box domain-containing protein. (314 aa) |
| | AMN1 | Antagonist of mitotic exit network 1 homolog. (266 aa) |
| | LSM7 | Uncharacterized protein. (201 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1948 aa) |
| | DCAF11 | Uncharacterized protein. (92 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (268 aa) |
| | FBXL22 | F-box and leucine rich repeat protein 22. (226 aa) |
| | FBXL3 | F-box and leucine rich repeat protein 3. (433 aa) |
| | SPSB1 | SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa) |
| | FBXO31 | F-box protein 31. (573 aa) |
| | KLHL24 | BTB domain-containing protein. (600 aa) |
| | DCAF6 | WD_REPEATS_REGION domain-containing protein. (486 aa) |
| | CDC20B | Cell division cycle 20B. (403 aa) |
| | KLHL9 | Kelch-like protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). (655 aa) |
| | FBXO45 | F-box protein 45. (107 aa) |
| | FBXL12 | Uncharacterized protein. (471 aa) |
| | ENSGALP00000070347 | Uncharacterized protein. (229 aa) |
| | ANAPC10 | DOC domain-containing protein. (255 aa) |
| | FBXO18 | F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: p [...] (1021 aa) |
| | ENSGALP00000071775 | RING-type domain-containing protein. (343 aa) |
| | DDA1 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (166 aa) |
| | CDC26 | Uncharacterized protein. (84 aa) |
| | ENSGALP00000072290 | WD_REPEATS_REGION domain-containing protein. (89 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (697 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (723 aa) |
| | KLHDC3 | Kelch domain containing 3. (382 aa) |
| | ENSGALP00000073240 | Uncharacterized protein. (430 aa) |
| | ENSGALP00000073605 | Uncharacterized protein. (253 aa) |
| | DCAF8 | Uncharacterized protein. (444 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa) |
| | DCAF15 | DDB1 and CUL4 associated factor 15. (619 aa) |
