STRINGSTRING
CRKL CRKL RAPSN RAPSN SYNGR1 SYNGR1 LAMA4 LAMA4 SLC5A7 SLC5A7 LOC428094 LOC428094 PDZRN4 PDZRN4 PRKAR1A PRKAR1A APP APP SYNGR2 SYNGR2 SYNJ2BP-2 SYNJ2BP-2 SNTA1 SNTA1 UNC13A UNC13A UNC13C UNC13C DLGAP4 DLGAP4 CFAP52 CFAP52 LAMB2 LAMB2 TBC1D24 TBC1D24 TRIP4 TRIP4 STXBP5L STXBP5L PDZRN3 PDZRN3 DLGAP3 DLGAP3 ASCC1 ASCC1 MYH9 MYH9 COLQ COLQ FCHSD2 FCHSD2 PSEN2 PSEN2 AGRN AGRN NEFL NEFL ENSGALP00000064934 ENSGALP00000064934 SYNC SYNC UNC13C-2 UNC13C-2 LAMA2 LAMA2 STXBP5 STXBP5 CDK5 CDK5 PSEN1 PSEN1 ENSGALP00000069792 ENSGALP00000069792 SYNGR3 SYNGR3 FCHSD1 FCHSD1 ENSGALP00000074167 ENSGALP00000074167 UNC13B UNC13B P2RX7 P2RX7 VCL VCL SERPINE2 SERPINE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (193 aa)
RAPSN43 kDa receptor-associated protein of the synapse; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity). Belongs to the RAPsyn family. (412 aa)
SYNGR1Synaptogyrin. (233 aa)
LAMA4Laminin subunit alpha 4. (1827 aa)
SLC5A7Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (578 aa)
LOC428094Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (563 aa)
PDZRN4PDZ domain containing ring finger 4. (836 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
SYNGR2Synaptogyrin. (225 aa)
SYNJ2BP-2PDZ domain-containing protein. (146 aa)
SNTA1Syntrophin alpha 1. (484 aa)
UNC13AUncharacterized protein. (1738 aa)
UNC13CUncharacterized protein. (1097 aa)
DLGAP4DLG associated protein 4. (985 aa)
CFAP52Rab-GAP TBC domain-containing protein. (628 aa)
LAMB2Uncharacterized protein. (1802 aa)
TBC1D24Uncharacterized protein. (561 aa)
TRIP4Thyroid hormone receptor interactor 4. (581 aa)
STXBP5LSyntaxin binding protein 5 like. (1184 aa)
PDZRN3PDZ domain containing ring finger 3. (1074 aa)
DLGAP3DLG associated protein 3. (960 aa)
ASCC1Activating signal cointegrator 1 complex subunit 1. (355 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
COLQCollagen like tail subunit of asymmetric acetylcholinesterase. (298 aa)
FCHSD2FCH and double SH3 domains 2. (1105 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (455 aa)
AGRNAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (373 aa)
ENSGALP00000064934Uncharacterized protein. (2030 aa)
SYNCSyncoilin, intermediate filament protein. (672 aa)
UNC13C-2Uncharacterized protein. (411 aa)
LAMA2Uncharacterized protein. (598 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
ENSGALP00000069792L27 domain-containing protein. (47 aa)
SYNGR3MARVEL domain-containing protein. (295 aa)
FCHSD1FCH and double SH3 domains 1. (788 aa)
ENSGALP00000074167Uncharacterized protein. (178 aa)
UNC13BUnc-13 homolog B. (1574 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (442 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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