Your Input: | |
| | UBE2L6 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (153 aa) |
| | SPART | Spartin. (631 aa) |
| | ENSGALP00000073564 | Uncharacterized protein. (243 aa) |
| | OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1. (439 aa) |
| | BAG4 | BCL2 associated athanogene 4. (364 aa) |
| | RTN2 | Reticulon. (316 aa) |
| | ENSGALP00000072214 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (309 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa) |
| | TXNIP | Thioredoxin interacting protein. (430 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa) |
| | DNM1L | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | LOC107056305 | Uncharacterized protein. (314 aa) |
| | RALB | RAS like proto-oncogene B. (259 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (981 aa) |
| | FAM178B | Uncharacterized protein. (653 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | LOC112530287 | Mothers against decapentaplegic homolog. (343 aa) |
| | ENSGALP00000069273 | EST1_DNA_bind domain-containing protein. (492 aa) |
| | TANK | TBD domain-containing protein. (422 aa) |
| | TMBIM6 | Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (345 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (711 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa) |
| | ENSGALP00000068158 | Uncharacterized protein. (384 aa) |
| | ATXN3L | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By [...] (375 aa) |
| | UBXN7 | UBX domain protein 7. (623 aa) |
| | FBXW9 | F-box domain-containing protein. (337 aa) |
| | RTN3 | Reticulon. (320 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa) |
| | SPOPL | Speckle type BTB/POZ protein like. (392 aa) |
| | RNF34 | RING-type domain-containing protein. (359 aa) |
| | MAP1LC3B | Uncharacterized protein. (125 aa) |
| | RFFL | RING-type domain-containing protein. (360 aa) |
| | CASP18 | Initiator caspase; Belongs to the peptidase C14A family. (464 aa) |
| | PMLL | Uncharacterized protein. (464 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (455 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (158 aa) |
| | YWHAZ | 14-3-3 protein zeta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (251 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa) |
| | SKI | Ski oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity). (750 aa) |
| | TRAF1 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | UBE2J2 | Ubiquitin conjugating enzyme E2 J2. (259 aa) |
| | BRCA1 | Uncharacterized protein. (1749 aa) |
| | ERLIN2 | ER lipid raft associated 2. (342 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (178 aa) |
| | ERLIN1 | PHB domain-containing protein. (347 aa) |
| | FAF2 | Fas associated factor family member 2. (445 aa) |
| | TRAF4 | TNF receptor-associated factor. (470 aa) |
| | MFN2 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa) |
| | CACYBP | Calcyclin binding protein. (221 aa) |
| | VCL | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa) |
| | TRIM37 | Uncharacterized protein. (983 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) |
| | GLMN | Glomulin, FKBP associated protein. (628 aa) |
| | TSG101 | Uncharacterized protein. (390 aa) |
| | CAMLG | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (289 aa) |
| | SLC22A18 | Solute carrier family 22 member 18. (427 aa) |
| | DET1 | Uncharacterized protein. (551 aa) |
| | PRKAR2A | Protein kinase cAMP-dependent type II regulatory subunit alpha. (400 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (148 aa) |
| | PRR5L | Proline rich 5 like. (366 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1189 aa) |
| | PRKAR2B | Protein kinase cAMP-dependent type II regulatory subunit beta. (415 aa) |
| | HSPD1 | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa) |
| | RAD18 | Uncharacterized protein. (672 aa) |
| | ARRDC1 | Arrestin_C domain-containing protein. (421 aa) |
| | USP13 | Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). (862 aa) |
| | ASB4 | Ankyrin repeat and SOCS box containing 4. (425 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | LRPPRC | Leucine rich pentatricopeptide repeat containing. (1371 aa) |
| | CCT2 | Uncharacterized protein. (535 aa) |
| | MAP1LC3C | Microtubule associated protein 1 light chain 3 gamma. (142 aa) |
| | RANGAP1 | RanGAP1_C domain-containing protein. (579 aa) |
| | RTN1 | Reticulon. (760 aa) |
| | JKAMP | Uncharacterized protein. (314 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1691 aa) |
| | FBXO7 | F-box domain-containing protein. (526 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | MC4R | G_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa) |
| | BAG1 | Uncharacterized protein. (209 aa) |
| | SNX9 | Sorting nexin. (600 aa) |
| | AICDA | CMP/dCMP-type deaminase domain-containing protein. (198 aa) |
| | PACRGL | Parkin coregulated like. (309 aa) |
| | TPI1 | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (248 aa) |
| | GABARAPL1 | GABA type A receptor associated protein like 1. (117 aa) |
| | BLZF1 | Basic leucine zipper nuclear factor 1. (397 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (874 aa) |
| | SMC6 | SMC_N domain-containing protein. (1096 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (767 aa) |
| | FZD4 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 ki [...] (525 aa) |
| | LOC419074 | Uncharacterized protein. (765 aa) |
| | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa) |
| | ANKRA2 | ANK_REP_REGION domain-containing protein. (313 aa) |
| | UBASH3A | Uncharacterized protein. (626 aa) |
| | TRIB2 | TRB2 protein. (343 aa) |
| | RIPK1 | Uncharacterized protein. (682 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (872 aa) |
| | CD40 | Uncharacterized protein. (299 aa) |
| | MYOD1 | Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa) |
| | UBE2G1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | PRKACB | Uncharacterized protein; Belongs to the protein kinase superfamily. (398 aa) |
| | TNK2 | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1175 aa) |
| | BAG2 | BCL2 associated athanogene 2. (224 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (234 aa) |
| | ATF6 | Activating transcription factor 6. (671 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | SPOP | Speckle type BTB/POZ protein. (374 aa) |
| | USP19 | Ubiquitin specific peptidase 19. (1434 aa) |
| | FAF1 | Fas associated factor 1. (650 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (662 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (529 aa) |
| | LAPTM4B | Lysosomal protein transmembrane 4 beta. (224 aa) |
| | RALA | RAS like proto-oncogene A. (206 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (493 aa) |
| | SNCAIP | Synuclein alpha interacting protein. (960 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | LYN | Tyrosine-protein kinase. (491 aa) |
| | PINK1 | PTEN induced kinase 1. (364 aa) |
| | UBB | Polyubiquitin-B. (229 aa) |
| | HSPBP1 | Uncharacterized protein. (330 aa) |
| | YOD1 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (346 aa) |
| | UBASH3B | Ubiquitin associated and SH3 domain containing B. (651 aa) |
| | PA2G4 | Peptidase_M24 domain-containing protein. (394 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (883 aa) |
| | WBP1L | WW domain binding protein 1 like. (343 aa) |
| | BID | BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). (300 aa) |
| | PIAS2 | Uncharacterized protein. (622 aa) |
| | UBOX5 | U-box domain containing 5. (534 aa) |
| | CHEK2 | Uncharacterized protein. (524 aa) |
| | UBE2A | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling, preventing NF-kappa-B activation, and BMP-SMAD1 signaling pathway. Binds to regulatory elements in target promoter regions (By similarity). (431 aa) |
| | RPS27A | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa) |
| | RPL5 | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa) |
| | PRKAR1B | Protein kinase cAMP-dependent type I regulatory subunit beta. (422 aa) |
| | FBXW7 | Uncharacterized protein. (586 aa) |
| | CUL2 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | MAP1LC3A | Microtubule associated protein 1 light chain 3 alpha. (121 aa) |
| | ENSGALP00000051793 | Uncharacterized protein. (360 aa) |
| | STX8 | t-SNARE coiled-coil homology domain-containing protein. (273 aa) |
| | UBE2L3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (339 aa) |
| | ARIH1 | RBR-type E3 ubiquitin transferase. (552 aa) |
| | NDUFS2 | NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (832 aa) |
| | LOC101747587 | Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (406 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (252 aa) |
| | SQSTM1 | Sequestosome 1. (453 aa) |
| | CASC3 | CASC3 exon junction complex subunit. (657 aa) |
| | PPARGC1A | RRM domain-containing protein. (795 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (388 aa) |
| | FANCL | Fanconi anemia protein FANCL. (373 aa) |
| | RTN4 | Reticulon. (1159 aa) |
| | AXIN2 | Uncharacterized protein. (837 aa) |
| | CACUL1 | Cullin domain-containing protein; Belongs to the cullin family. (377 aa) |
| | NEDD8 | NEDD8 ubiquitin like modifier. (85 aa) |
| | TNFRSF8 | TNFR-Cys domain-containing protein. (467 aa) |
| | LAPTM5 | Lysosomal protein transmembrane 5. (256 aa) |
| | ENSGALP00000055781 | Cullin_Nedd8 domain-containing protein. (146 aa) |
| | SMG5 | PINc domain-containing protein. (1049 aa) |
| | TNFRSF1B | Uncharacterized protein. (462 aa) |
| | HM13 | Histocompatibility minor 13. (701 aa) |
| | SMAD7B | Mothers against decapentaplegic homolog. (388 aa) |
| | DBT | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa) |
| | BAG5 | BAG family molecular chaperone regulator 5; May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. (450 aa) |
| | UBE2K | Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | LOC107051192 | RanBP2-type domain-containing protein. (1255 aa) |
| | UBE2J1 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (317 aa) |
| | PACRG | Parkin coregulated. (254 aa) |
| | GPI | Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa) |
| | SYT11 | Synaptotagmin 11. (432 aa) |
| | ENSGALP00000074323 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (170 aa) |
| | ENSGALP00000074157 | Uncharacterized protein. (199 aa) |
| | AXIN1 | Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa) |
