(43 nodes) Positive regulation of protein binding network (Gallus gallus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RFNG	Beta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Plays an important role in limb outgrowth, it directs the formation and positioning of the apical ectodermal ridge (AER), one of the key organizer centers of vertebrate limb development. (372 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	POLDIP2	ApaG domain-containing protein. (373 aa)
	VTN	SMB domain-containing protein. (453 aa)
	ABL1	Tyrosine-protein kinase. (1111 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4382 aa)
	MAPRE1	Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Belongs to the MAPRE family. (263 aa)
	SPPL3	Signal peptide peptidase like 3. (384 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	NVL	Uncharacterized protein. (855 aa)
	EP300	E1A binding protein p300. (2450 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase. (352 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1346 aa)
	ADD1	Aldolase_II domain-containing protein. (736 aa)
	BLK	Tyrosine-protein kinase. (526 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
	APP	BPTI/Kunitz inhibitor domain-containing protein. (751 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
	CAV1	Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning. (363 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (964 aa)
	HIP1R	Uncharacterized protein. (977 aa)
	ADD2	Adducin 2. (775 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1652 aa)
	KRIT1	Uncharacterized protein. (736 aa)
	LRRK2	Uncharacterized protein. (2557 aa)
	ABL2	Tyrosine-protein kinase. (1159 aa)
	AKTIP	AKT-interacting protein; May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity); Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. (351 aa)
	RAN	GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (162 aa)
	CAPRIN2	Caprin family member 2. (1267 aa)
	PLXND1	Plexin D1. (1928 aa)
	MMP9	Uncharacterized protein. (713 aa)
	DTX3L	Deltex E3 ubiquitin ligase 3L. (737 aa)
	CDK5	Protein kinase domain-containing protein. (522 aa)
	PSEN1	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (314 aa)
	PTK2	Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] (1102 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa)
	RIPK3	Uncharacterized protein. (424 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (766 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSGALP00000006154	ENSGALP00000052767	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
ABL2	ABL1	ENSGALP00000052767	ENSGALP00000006154	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
ADD1	ADD2	ENSGALP00000025213	ENSGALP00000050830	Aldolase_II domain-containing protein.	Adducin 2.	0.966
ADD2	ADD1	ENSGALP00000050830	ENSGALP00000025213	Adducin 2.	Aldolase_II domain-containing protein.	0.966
APP	CDK5	ENSGALP00000036014	ENSGALP00000068854	BPTI/Kunitz inhibitor domain-containing protein.	Protein kinase domain-containing protein.	0.539
APP	EP300	ENSGALP00000036014	ENSGALP00000019537	BPTI/Kunitz inhibitor domain-containing protein.	E1A binding protein p300.	0.625
APP	IDE	ENSGALP00000036014	ENSGALP00000047668	BPTI/Kunitz inhibitor domain-containing protein.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.946
APP	PRKN	ENSGALP00000036014	ENSGALP00000071728	BPTI/Kunitz inhibitor domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.503
APP	PSEN1	ENSGALP00000036014	ENSGALP00000069770	BPTI/Kunitz inhibitor domain-containing protein.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.990
CAV1	CAV3	ENSGALP00000043610	ENSGALP00000013584	Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.903
CAV1	CLDN5	ENSGALP00000043610	ENSGALP00000002474	Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.518
CAV1	MMP9	ENSGALP00000043610	ENSGALP00000068659	Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).	Uncharacterized protein.	0.417
CAV1	PTK2	ENSGALP00000043610	ENSGALP00000071114	Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).	Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...]	0.417
CAV3	CAV1	ENSGALP00000013584	ENSGALP00000043610	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).	0.903
CDK5	APP	ENSGALP00000068854	ENSGALP00000036014	Protein kinase domain-containing protein.	BPTI/Kunitz inhibitor domain-containing protein.	0.539
CDK5	PRKN	ENSGALP00000068854	ENSGALP00000071728	Protein kinase domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.440
CDK5	PSEN1	ENSGALP00000068854	ENSGALP00000069770	Protein kinase domain-containing protein.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.610
CLDN5	CAV1	ENSGALP00000002474	ENSGALP00000043610	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).	0.518
CLDN5	MMP9	ENSGALP00000002474	ENSGALP00000068659	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.702
EP300	APP	ENSGALP00000019537	ENSGALP00000036014	E1A binding protein p300.	BPTI/Kunitz inhibitor domain-containing protein.	0.625