12 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HPS1	Uncharacterized protein. (788 aa)
	SHROOM2	Shroom family member 2. (1755 aa)
	ASIP	Agouti signaling protein. (139 aa)
	PMEL	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. (740 aa)
	HPS4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (702 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
	RAB32	Uncharacterized protein. (218 aa)
	BLOC1S4	Biogenesis of lysosomal organelles complex 1 subunit 4. (214 aa)
	GPR143	Uncharacterized protein. (391 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
	RAB38	RAB38, member RAS oncogene family. (212 aa)
	ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group). (894 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASIP	TYRP1	ENSGALP00000054181	ENSGALP00000037537	Agouti signaling protein.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.860
BLOC1S4	HPS1	ENSGALP00000022076	ENSGALP00000072544	Biogenesis of lysosomal organelles complex 1 subunit 4.	Uncharacterized protein.	0.574
BLOC1S4	HPS4	ENSGALP00000022076	ENSGALP00000008962	Biogenesis of lysosomal organelles complex 1 subunit 4.	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	0.585
GPR143	PMEL	ENSGALP00000026765	ENSGALP00000051268	Uncharacterized protein.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.578
GPR143	TYRP1	ENSGALP00000026765	ENSGALP00000037537	Uncharacterized protein.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.774
HPS1	BLOC1S4	ENSGALP00000072544	ENSGALP00000022076	Uncharacterized protein.	Biogenesis of lysosomal organelles complex 1 subunit 4.	0.574
HPS1	HPS4	ENSGALP00000072544	ENSGALP00000008962	Uncharacterized protein.	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	0.998
HPS1	RAB32	ENSGALP00000072544	ENSGALP00000020074	Uncharacterized protein.	Uncharacterized protein.	0.517
HPS1	RAB38	ENSGALP00000072544	ENSGALP00000043111	Uncharacterized protein.	RAB38, member RAS oncogene family.	0.517
HPS4	BLOC1S4	ENSGALP00000008962	ENSGALP00000022076	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Biogenesis of lysosomal organelles complex 1 subunit 4.	0.585
HPS4	HPS1	ENSGALP00000008962	ENSGALP00000072544	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Uncharacterized protein.	0.998
HPS4	RAB32	ENSGALP00000008962	ENSGALP00000020074	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Uncharacterized protein.	0.546
HPS4	RAB38	ENSGALP00000008962	ENSGALP00000043111	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	RAB38, member RAS oncogene family.	0.546
PMEL	GPR143	ENSGALP00000051268	ENSGALP00000026765	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	Uncharacterized protein.	0.578
PMEL	TYRP1	ENSGALP00000051268	ENSGALP00000037537	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.915
RAB32	HPS1	ENSGALP00000020074	ENSGALP00000072544	Uncharacterized protein.	Uncharacterized protein.	0.517
RAB32	HPS4	ENSGALP00000020074	ENSGALP00000008962	Uncharacterized protein.	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	0.546
RAB32	RAB38	ENSGALP00000020074	ENSGALP00000043111	Uncharacterized protein.	RAB38, member RAS oncogene family.	0.428
RAB38	HPS1	ENSGALP00000043111	ENSGALP00000072544	RAB38, member RAS oncogene family.	Uncharacterized protein.	0.517
RAB38	HPS4	ENSGALP00000043111	ENSGALP00000008962	RAB38, member RAS oncogene family.	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	0.546