STRINGSTRING
SRSF5 SRSF5 E1C066_CHICK E1C066_CHICK PIK3R2 PIK3R2 SOGA1 SOGA1 MTOR MTOR SIRT1 SIRT1 INPP5K INPP5K CPEB1 CPEB1 PRKCZ PRKCZ ERRFI1 ERRFI1 GH GH RARRES2 RARRES2 TLDC1 TLDC1 EIF6 EIF6 MYO5C MYO5C SESN2 SESN2 SP1 SP1 MYO5A MYO5A PKLR PKLR OTOP1 OTOP1 SRSF6 SRSF6 INSR INSR SLC2A1 SLC2A1 KBTBD2 KBTBD2 SRSF5A SRSF5A LYN LYN BCAR1 BCAR1 OGT OGT RAB12 RAB12 ZDHHC7 ZDHHC7 APRT APRT INSIG2 INSIG2 LOC100858814 LOC100858814 TROJANZ TROJANZ INHBB INHBB LOC100858919 LOC100858919 GHSR GHSR PRKCI PRKCI RAB10 RAB10 RAB31 RAB31 INSIG1 INSIG1 CYFIP1 CYFIP1 SYAP1 SYAP1 HADHA HADHA GCLC GCLC DENND4C DENND4C PIK3R3 PIK3R3 CPEB2 CPEB2 PTPN2 PTPN2 INSRR INSRR ZNF106 ZNF106 IRS4 IRS4 EGR1 EGR1 PCK1 PCK1 GOT1 GOT1 NCOA5 NCOA5 EEF2K EEF2K PDPK1 PDPK1 ABCC8 ABCC8 XBP1 XBP1 ADIPOQ ADIPOQ PIK3AP1 PIK3AP1 APPL1 APPL1 GHRHR GHRHR SLC27A4 SLC27A4 IRS1 IRS1 CSRP3 CSRP3 LPIN2 LPIN2 IGF1R IGF1R CAPN10 CAPN10 PRLH PRLH EIF4EBP2 EIF4EBP2 PTPRA PTPRA TNFSF10 TNFSF10 AKT3 AKT3 RAB10L RAB10L CAV2 CAV2 LPIN1 LPIN1 EPRS EPRS STXBP3 STXBP3 AKT2 AKT2 KHK KHK ACVR1C ACVR1C SLC27A1 SLC27A1 GSK3B GSK3B AKT1 AKT1 SORT1 SORT1 STXBP4 STXBP4 PIK3R1 PIK3R1 DNAI1 DNAI1 PPARG PPARG TSC1 TSC1 LOC107049937 LOC107049937 INPPL1 INPPL1 SCAP SCAP PCK2 PCK2 PCSK9 PCSK9 USF1 USF1 RB1 RB1 SLC9A1 SLC9A1 KCNQ1 KCNQ1 GPLD1 GPLD1 WDTC1 WDTC1 ENSGALP00000073164 ENSGALP00000073164 C2CD5 C2CD5 LOC100858953 LOC100858953 SRSF4 SRSF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRSF5Uncharacterized protein. (264 aa)
E1C066_CHICKUncharacterized protein. (258 aa)
PIK3R2Uncharacterized protein. (731 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1719 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
INPP5KIPPc domain-containing protein. (465 aa)
CPEB1RRM domain-containing protein. (561 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (465 aa)
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
RARRES2Chemerin. (162 aa)
TLDC1MTOR-associated protein MEAK7; Activates an alternative mTOR signaling to regulate cell proliferation and migration. (468 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
MYO5CMyosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1737 aa)
SESN2Uncharacterized protein. (474 aa)
SP1Transcription factor. (760 aa)
MYO5AUnconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity). (1830 aa)
PKLRPyruvate kinase PKM; Plays a key role in glycolysis; Belongs to the pyruvate kinase family. (550 aa)
OTOP1Otopetrin 1. (609 aa)
SRSF6Uncharacterized protein. (351 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. (490 aa)
KBTBD2Kelch repeat and BTB domain containing 2. (623 aa)
SRSF5AUncharacterized protein. (278 aa)
LYNTyrosine-protein kinase. (491 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (905 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa)
RAB12RAB12, member RAS oncogene family. (290 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (305 aa)
APRTPribosyltran domain-containing protein. (179 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
LOC100858814Pribosyltran domain-containing protein. (210 aa)
TROJANZUncharacterized protein. (494 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (392 aa)
LOC100858919Uncharacterized protein. (580 aa)
GHSRG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (561 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
INSIG1Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (252 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
SYAP1BSD domain-containing protein. (357 aa)
HADHAUncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (770 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
DENND4CDENN domain containing 4C. (1950 aa)
PIK3R3Uncharacterized protein. (463 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (558 aa)
PTPN2Uncharacterized protein. (597 aa)
INSRRTyrosine-protein kinase receptor. (1333 aa)
ZNF106Zinc finger protein 106. (1036 aa)
IRS4Insulin receptor substrate 4. (1164 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa)
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (412 aa)
NCOA5Nuclear receptor coactivator 5. (715 aa)
EEF2KEukaryotic elongation factor 2 kinase. (742 aa)
PDPK1Protein kinase domain-containing protein. (556 aa)
ABCC8ATP binding cassette subfamily C member 8. (1595 aa)
XBP1BZIP domain-containing protein. (372 aa)
ADIPOQC1q domain-containing protein. (244 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll- like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival o [...] (800 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (806 aa)
GHRHRG protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
SLC27A4Solute carrier family 27 member 4. (802 aa)
IRS1Insulin receptor substrate 1. (1178 aa)
CSRP3Uncharacterized protein. (194 aa)
LPIN2LNS2 domain-containing protein. (918 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
PRLHUncharacterized protein. (87 aa)
EIF4EBP2Uncharacterized protein. (114 aa)
PTPRAUncharacterized protein. (867 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAB10LUncharacterized protein. (208 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
LPIN1Lipin 1. (1003 aa)
EPRSUncharacterized protein. (1689 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
AKT2Non-specific serine/threonine protein kinase. (881 aa)
KHKKetohexokinase. (291 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
SLC27A1AMP-binding domain-containing protein. (719 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SORT1Sortilin. (954 aa)
STXBP4Syntaxin binding protein 4. (736 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DNAI1Dynein axonemal intermediate chain 1. (687 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
TSC1Uncharacterized protein. (275 aa)
LOC107049937Uncharacterized protein. (608 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1175 aa)
SCAPSREBF chaperone. (1316 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. (414 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa)
USF1BHLH domain-containing protein. (614 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
WDTC1WD and tetratricopeptide repeats 1. (697 aa)
ENSGALP00000073164LNS2 domain-containing protein. (153 aa)
C2CD5C2 calcium dependent domain containing 5. (1219 aa)
LOC100858953Fibronectin type-III domain-containing protein. (572 aa)
SRSF4Serine and arginine rich splicing factor 4. (475 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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