STRINGSTRING
RTFDC1 RTFDC1 LIG1 LIG1 POLA1 POLA1 DONSON DONSON GINS3 GINS3 RAD51 RAD51 MCM6 MCM6 BRCA2 BRCA2 MCM2 MCM2 MCM3 MCM3 CDT1 CDT1 GMNN GMNN ZNF830 ZNF830 GINS1 GINS1 MCM4 MCM4 CDC45 CDC45 UPF1 UPF1 ATAD5 ATAD5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RTFDC1Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Interacts with nascent DNA. Belongs to the rtf2 family. (306 aa)
LIG1DNA ligase 1; Belongs to the ATP-dependent DNA ligase family. (961 aa)
POLA1DNA polymerase. (1496 aa)
DONSONDownstream neighbor of SON. (515 aa)
GINS3GINS complex subunit 3. (214 aa)
RAD51DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa)
MCM6DNA helicase; Belongs to the MCM family. (825 aa)
BRCA2Tower domain-containing protein. (3397 aa)
MCM2DNA helicase; Belongs to the MCM family. (929 aa)
MCM3DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
CDT1Chromatin licensing and DNA replication factor 1. (745 aa)
GMNNUncharacterized protein. (224 aa)
ZNF830Zinc finger protein 830. (532 aa)
GINS1Sld5 domain-containing protein. (195 aa)
MCM4DNA helicase; Belongs to the MCM family. (859 aa)
CDC45Cell division cycle 45. (566 aa)
UPF1UPF1 RNA helicase and ATPase. (1117 aa)
ATAD5AAA domain-containing protein. (1816 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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