(53 nodes) Monocarboxylic acid binding network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGALP00000073118	ACC_central domain-containing protein. (87 aa)
	FABP6	FABP domain-containing protein. (128 aa)
	ACOX1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
	LOC769899	Avidin-related protein 4/5; Belongs to the avidin/streptavidin family. (150 aa)
	RBP7	Retinol binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
	LBFABP	Fatty acid-binding protein, liver; Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit. (126 aa)
	E1BT64_CHICK	Uncharacterized protein. (206 aa)
	RBP2	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	NR2F2	COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (410 aa)
	ACOX2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (675 aa)
	PLA2G1B	Phospholipase A(2). (148 aa)
	F1N9G3_CHICK	Phospholipase A(2). (111 aa)
	LOC417013	Uncharacterized protein. (638 aa)
	NAPEPLD	Lactamase_B domain-containing protein. (463 aa)
	NR1H4	Farnesoid X receptor. (473 aa)
	FABP2	Intestinal fatty acid-binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	ACOX3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (706 aa)
	FABP1	Fatty acid-binding protein, liver. (127 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
	NR2F1	Nuclear receptor subfamily 2 group F member 1. (418 aa)
	STARD5	StAR related lipid transfer domain containing 5. (210 aa)
	CRABP1	Cellular retinoic acid-binding protein 1; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. (137 aa)
	F1NVW9_CHICK	Uncharacterized protein. (75 aa)
	ALOX5AP	Uncharacterized protein. (161 aa)
	FFAR4	Free fatty acid receptor 4. (349 aa)
	CRABP2	Cellular retinoic acid-binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
	ACACA	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. (2355 aa)
	NR2F6	Nuclear receptor subfamily 2 group F member 6. (379 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
	EXFABP	Extracellular fatty acid-binding protein; Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor; Belongs to the calycin superfamily. Lipocalin family. (178 aa)
	FABP4	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	RBP1	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	PSAP	Prosaposin; The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. (538 aa)
	PRR7	Proline rich 7, synaptic. (231 aa)
	ENSGALP00000051771	Biotin carboxylation domain-containing protein. (177 aa)
	AVR2	Avidin-related protein 2. (320 aa)
	FABP9	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	FABP3	Heart fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	FABP5	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (291 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa)
	CYP26C1	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (510 aa)
	ACACB	Uncharacterized protein. (879 aa)
	FABP7	Fatty acid-binding protein, brain; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	LOC777082	Uncharacterized protein. (414 aa)
	ENSGALP00000067304	Uncharacterized protein. (87 aa)
	PC	Lipoyl-binding domain-containing protein. (317 aa)
	PODN	Podocan. (632 aa)
	LOC427416	Uncharacterized protein. (289 aa)
	ENSGALP00000071256	Biotin carboxylation domain-containing protein. (250 aa)
	HLCS	Holocarboxylase synthetase. (933 aa)
	AVD	Avidin. (250 aa)
	AVDL	Uncharacterized protein. (283 aa)
	PPARD	Uncharacterized protein. (545 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSGALP00000043760	ENSGALP00000058059	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Uncharacterized protein.	0.902
ACACA	ACOX1	ENSGALP00000043760	ENSGALP00000003376	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.796
ACACA	ACOX2	ENSGALP00000043760	ENSGALP00000011541	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.547
ACACA	ACOX3	ENSGALP00000043760	ENSGALP00000025093	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.587
ACACA	ENSGALP00000071256	ENSGALP00000043760	ENSGALP00000071256	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Biotin carboxylation domain-containing protein.	0.439
ACACA	FABP1	ENSGALP00000043760	ENSGALP00000025639	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Fatty acid-binding protein, liver.	0.454
ACACA	FABP3	ENSGALP00000043760	ENSGALP00000053529	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Heart fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.550
ACACA	FABP4	ENSGALP00000043760	ENSGALP00000045411	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.527
ACACA	FABP5	ENSGALP00000043760	ENSGALP00000054856	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.404
ACACA	HLCS	ENSGALP00000043760	ENSGALP00000071699	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Holocarboxylase synthetase.	0.898
ACACA	LBFABP	ENSGALP00000043760	ENSGALP00000006574	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Fatty acid-binding protein, liver; Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit.	0.403
ACACA	PC	ENSGALP00000043760	ENSGALP00000068177	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Lipoyl-binding domain-containing protein.	0.585
ACACB	ACACA	ENSGALP00000058059	ENSGALP00000043760	Uncharacterized protein.	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	0.902
ACACB	ACOX1	ENSGALP00000058059	ENSGALP00000003376	Uncharacterized protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.765
ACACB	ACOX2	ENSGALP00000058059	ENSGALP00000011541	Uncharacterized protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.412
ACACB	ACOX3	ENSGALP00000058059	ENSGALP00000025093	Uncharacterized protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.526
ACACB	ENSGALP00000051771	ENSGALP00000058059	ENSGALP00000051771	Uncharacterized protein.	Biotin carboxylation domain-containing protein.	0.900
ACACB	ENSGALP00000071256	ENSGALP00000058059	ENSGALP00000071256	Uncharacterized protein.	Biotin carboxylation domain-containing protein.	0.439
ACACB	ENSGALP00000073118	ENSGALP00000058059	ENSGALP00000073118	Uncharacterized protein.	ACC_central domain-containing protein.	0.921
ACACB	HLCS	ENSGALP00000058059	ENSGALP00000071699	Uncharacterized protein.	Holocarboxylase synthetase.	0.459