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ACOT9 ACOT9 LOC423222 LOC423222 DCAKD DCAKD ACOT4-2 ACOT4-2 ACOT7 ACOT7 PANK4 PANK4 HSD17B4 HSD17B4 ACSM3 ACSM3 MCCC2 MCCC2 ACSS2 ACSS2 ACSL3 ACSL3 MLYCD MLYCD PANK1 PANK1 ACSL6 ACSL6 ACOT8 ACOT8 MVD MVD SUCLG2 SUCLG2 DLAT DLAT ACSL4 ACSL4 ACSS1 ACSS1 GPAM GPAM CROT CROT AADAT AADAT ACSS1B ACSS1B PAPSS1 PAPSS1 MCCC2L MCCC2L OXSM OXSM MVK MVK HMGCR HMGCR MPC2 MPC2 ACOT12 ACOT12 ELOVL4 ELOVL4 ELOVL5 ELOVL5 ACAT1 ACAT1 MCEE MCEE FAR1 FAR1 COASY COASY PIPOX PIPOX ACACA ACACA TDO2 TDO2 PAPSS2 PAPSS2 PDHB PDHB PANK2 PANK2 HMGCS1 HMGCS1 BAAT BAAT NUDT19 NUDT19 ACOT11 ACOT11 PDHA2 PDHA2 ENSGALP00000051771 ENSGALP00000051771 ELOVL1 ELOVL1 ACSM5 ACSM5 AASS AASS DLST DLST ACLY ACLY ACOT4 ACOT4 ELOVL7 ELOVL7 PDHX PDHX ACACB ACACB NUDT7 NUDT7 PPCDC PPCDC HDDC3 HDDC3 ACSL1 ACSL1 PMVK PMVK DIP2A DIP2A ENSGALP00000066498 ENSGALP00000066498 ACSM4 ACSM4 NUDT8 NUDT8 GPAT4 GPAT4 GCDH GCDH ELOVL6 ELOVL6 ACSL5 ACSL5 ENSGALP00000070487 ENSGALP00000070487 PANK3 PANK3 HMGCS2 HMGCS2 HTD2 HTD2 ELOVL2 ELOVL2 PPCS PPCS FAR2 FAR2 FITM2 FITM2 ENSGALP00000073118 ENSGALP00000073118
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACOT9Uncharacterized protein. (434 aa)
LOC423222Uncharacterized protein. (419 aa)
DCAKDDephospho-CoA kinase domain containing. (284 aa)
ACOT4-2Uncharacterized protein. (459 aa)
ACOT7Acyl-CoA thioesterase 7. (402 aa)
PANK4DUF89 domain-containing protein; Belongs to the type II pantothenate kinase family. (770 aa)
HSD17B417-beta-hydroxysteroid dehydrogenase type IV. (735 aa)
ACSM3Acyl-CoA synthetase medium chain family member 3. (578 aa)
MCCC2Methylcrotonoyl-CoA carboxylase 2. (560 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (696 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (713 aa)
MLYCDMalonyl-CoA decarboxylase. (501 aa)
PANK1Pantothenate kinase 1. (373 aa)
ACSL6AMP-binding domain-containing protein. (698 aa)
ACOT8Acyl-CoA thioesterase 8. (372 aa)
MVDMevalonate diphosphate decarboxylase. (629 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (432 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (632 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (670 aa)
ACSS1Acetyl-coenzyme A synthetase. (665 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
CROTCarnitine O-octanoyltransferase. (612 aa)
AADATAminoadipate aminotransferase. (428 aa)
ACSS1BAcetyl-coenzyme A synthetase. (682 aa)
PAPSS13'-phosphoadenosine 5'-phosphosulfate synthase 1. (624 aa)
MCCC2LUncharacterized protein. (606 aa)
OXSM3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (461 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (930 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (133 aa)
ACOT12Acyl-CoA thioesterase 12. (554 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa)
ACAT1Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa)
MCEEVOC domain-containing protein. (186 aa)
FAR1Fatty acyl-CoA reductase 1; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis. (515 aa)
COASYCoenzyme A synthase. (529 aa)
PIPOXPipecolic acid and sarcosine oxidase. (504 aa)
ACACAAcetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. (2355 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (478 aa)
PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2. (601 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PANK2Pantothenate kinase 2. (279 aa)
HMGCS1Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (542 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (409 aa)
NUDT19Nucleoside diphosphate-linked moiety X motif 19; Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty- acyl-CoA esters. (378 aa)
ACOT11Acyl-CoA thioesterase 11. (611 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (404 aa)
ENSGALP00000051771Biotin carboxylation domain-containing protein. (177 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (290 aa)
ACSM5Acyl-CoA synthetase medium chain family member 5. (580 aa)
AASSAminoadipate-semialdehyde synthase. (928 aa)
DLSTLipoyl-binding domain-containing protein. (474 aa)
ACLYATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1101 aa)
ACOT4BAAT_C domain-containing protein. (222 aa)
ELOVL7Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (279 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (502 aa)
ACACBUncharacterized protein. (879 aa)
NUDT7Nudix hydrolase domain-containing protein. (307 aa)
PPCDCPhosphopantothenoylcysteine decarboxylase. (204 aa)
HDDC3HD domain containing 3. (185 aa)
ACSL1AMP-binding domain-containing protein. (699 aa)
PMVKPhosphomevalonate kinase. (188 aa)
DIP2ADisco interacting protein 2 homolog A. (1567 aa)
ENSGALP00000066498Elongation of very long chain fatty acids protein. (143 aa)
ACSM4Uncharacterized protein. (579 aa)
NUDT8Uncharacterized protein. (105 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (455 aa)
GCDHGlutaryl-CoA dehydrogenase. (476 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (494 aa)
ACSL5AMP-binding domain-containing protein. (683 aa)
ENSGALP00000070487Uncharacterized protein. (460 aa)
PANK3Pantothenate kinase 3. (519 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (517 aa)
HTD2Hydroxyacyl-thioester dehydratase type 2. (171 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (297 aa)
PPCSPhosphopantothenoylcysteine synthetase. (414 aa)
FAR2Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa)
FITM2Fat storage inducing transmembrane protein 2. (396 aa)
ENSGALP00000073118ACC_central domain-containing protein. (87 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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