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IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa) | ||||
ADIPOQ | C1q domain-containing protein. (244 aa) | ||||
APOA1 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa) | ||||
MAP2K5 | Uncharacterized protein. (582 aa) | ||||
FGG | Fibrinogen C-terminal domain-containing protein. (438 aa) | ||||
IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) | ||||
SKAP1 | Src kinase associated phosphoprotein 1. (355 aa) |