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| | UBXN6 | UBX domain protein 6. (438 aa) |
| | FAM214B | Family with sequence similarity 214 member B. (606 aa) |
| | PDIA4 | Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (641 aa) |
| | DERL2 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa) |
| | FBXO44 | Uncharacterized protein. (304 aa) |
| | QRICH1 | DUF3504 domain-containing protein. (773 aa) |
| | HM13 | Histocompatibility minor 13. (701 aa) |
| | MARCHF6 | Membrane associated ring-CH-type finger 6. (921 aa) |
| | BAK1 | Uncharacterized protein. (216 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa) |
| | ENSGALP00000054501 | Uncharacterized protein. (152 aa) |
| | PDX1 | Homeobox domain-containing protein. (259 aa) |
| | FBXO2 | F-box protein 2. (247 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (406 aa) |
| | PDIA2 | Protein disulfide isomerase family A member 2. (539 aa) |
| | SESN2 | Uncharacterized protein. (474 aa) |
| | EIF2B5 | Eukaryotic translation initiation factor 2B subunit epsilon. (711 aa) |
| | ENSGALP00000051793 | Uncharacterized protein. (360 aa) |
| | FAM8A1 | Family with sequence similarity 8 member A1. (160 aa) |
| | CANX | Uncharacterized protein. (601 aa) |
| | EDEM3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (933 aa) |
| | MAN1B1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (655 aa) |
| | RNF139 | RING-type domain-containing protein. (677 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa) |
| | SGTA | TPR_REGION domain-containing protein. (312 aa) |
| | FAM214A | Protein FAM214A; Belongs to the FAM214 family. (1117 aa) |
| | RNF121 | Ring finger protein 121. (336 aa) |
| | BHLHA15 | Basic helix-loop-helix family member a15. (166 aa) |
| | SERP1 | Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa) |
| | RHBDD2 | Rhomboid domain-containing protein. (375 aa) |
| | ENSGALP00000049065 | Uncharacterized protein; Belongs to the AAA ATPase family. (448 aa) |
| | DDIT3 | C/EBP-like protein. (155 aa) |
| | YOD1 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (346 aa) |
| | UBE4A | U-box domain-containing protein. (1074 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa) |
| | DNAJB12 | J domain-containing protein. (374 aa) |
| | CALR | Calreticulin. (416 aa) |
| | SEL1L3 | SEL1L family member 3. (1124 aa) |
| | FAF1 | Fas associated factor 1. (650 aa) |
| | USP19 | Ubiquitin specific peptidase 19. (1434 aa) |
| | CDK5RAP3 | Uncharacterized protein. (619 aa) |
| | TMEM67 | Transmembrane protein 67. (976 aa) |
| | UFM1 | Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. Belongs to the UFM1 family. (85 aa) |
| | ATF6 | Activating transcription factor 6. (671 aa) |
| | TBL2 | Transducin beta like 2. (279 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (254 aa) |
| | ATG10 | Autophagy related 10. (227 aa) |
| | SELENOS | Uncharacterized protein. (207 aa) |
| | TMX4 | Thioredoxin domain-containing protein. (383 aa) |
| | UBXN10 | UBX domain protein 10. (326 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa) |
| | ATF4 | ATF4. (354 aa) |
| | UFD1L | Ubiquitin fusion-degradation 1-like protein. (307 aa) |
| | TMX1 | Thioredoxin related transmembrane protein 1. (153 aa) |
| | DNAJC3 | DnaJ homolog subfamily C member 3; May be involved in the unfolded protein response (UPR) during ER stress. (504 aa) |
| | UGGT2 | Uncharacterized protein. (1564 aa) |
| | DDRGK1 | DDRGK domain containing 1. (221 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa) |
| | RNF103 | RING-type domain-containing protein. (684 aa) |
| | ECPAS | Ecm29 proteasome adaptor and scaffold. (1872 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1232 aa) |
| | UFL1 | E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (789 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (874 aa) |
| | SGTB | TPR_REGION domain-containing protein. (304 aa) |
| | TMEM33 | Transmembrane protein 33. (251 aa) |
| | DNAJB14 | J domain-containing protein. (380 aa) |
| | SEC61B | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa) |
| | ERP44 | Endoplasmic reticulum protein 44. (406 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (386 aa) |
| | FOXRED2 | FAD dependent oxidoreductase domain containing 2. (680 aa) |
| | ERO1A | Uncharacterized protein. (463 aa) |
| | PLA2G6 | Uncharacterized protein. (796 aa) |
| | UBXN4 | Uncharacterized protein. (216 aa) |
| | JKAMP | Uncharacterized protein. (314 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | IL8L1 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa) |
| | STT3B | Uncharacterized protein. (801 aa) |
| | ANKZF1 | Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (717 aa) |
| | TMTC3 | Transmembrane O-mannosyltransferase targeting cadherins 3. (939 aa) |
| | SEL1L | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (791 aa) |
| | EIF2AK2 | Uncharacterized protein. (550 aa) |
| | CLGN | Calmegin. (655 aa) |
| | THBS1 | Uncharacterized protein. (1175 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1656 aa) |
| | USP13 | Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). (862 aa) |
| | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10. (797 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (506 aa) |
| | PDIA3 | Protein disulfide-isomerase A3; Belongs to the protein disulfide isomerase family. (505 aa) |
| | EDEM1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (616 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1284 aa) |
| | ERLEC1 | Endoplasmic reticulum lectin 1. (452 aa) |
| | CEBPB | CCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...] (328 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). (475 aa) |
| | VAPB | MSP domain-containing protein. (243 aa) |
| | PARP16 | Poly [ADP-ribose] polymerase. (328 aa) |
| | XBP1 | BZIP domain-containing protein. (372 aa) |
| | UBE2G2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (165 aa) |
| | SELENOK | Uncharacterized protein. (92 aa) |
| | RHBDD1 | Rhomboid domain containing 1. (317 aa) |
| | FICD | FIC domain containing. (455 aa) |
| | FAM129A | Uncharacterized protein. (1190 aa) |
| | AIFM1 | Uncharacterized protein. (689 aa) |
| | CALR3 | Calreticulin. (420 aa) |
| | GET4 | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...] (327 aa) |
| | ERN1 | Uncharacterized protein. (968 aa) |
| | FAF2 | Fas associated factor family member 2. (445 aa) |
| | ERLIN1 | PHB domain-containing protein. (347 aa) |
| | EDEM2 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (601 aa) |
| | AMFR | Autocrine motility factor receptor. (622 aa) |
| | ERLIN2 | ER lipid raft associated 2. (342 aa) |
| | NRBF2 | Uncharacterized protein. (435 aa) |
| | UBE4B | Ubiquitination factor E4B. (1346 aa) |
| | DNAJC18 | J domain-containing protein. (296 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (390 aa) |
| | ANKS4B | Ankyrin repeat and sterile alpha motif domain containing 4B. (403 aa) |
| | TMEM259 | Transmembrane protein 259. (738 aa) |
| | VCP | Valosin containing protein. (806 aa) |
| | UBE2J2 | Ubiquitin conjugating enzyme E2 J2. (259 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (493 aa) |
| | HERPUD1 | Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa) |
| | LOC430766 | Uncharacterized protein; Belongs to the AAA ATPase family. (820 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa) |
| | PPP1R15B | PP1c_bdg domain-containing protein. (202 aa) |
| | CCDC47 | Coiled-coil domain containing 47. (481 aa) |
| | ERMP1 | Endoplasmic reticulum metallopeptidase 1. (680 aa) |
| | ATF3 | Activating transcription factor 3. (181 aa) |
| | NFE2L2 | BZIP domain-containing protein. (593 aa) |
| | HERPUD2 | HERPUD family member 2. (436 aa) |
| | TMTC4 | Transmembrane O-mannosyltransferase targeting cadherins 4. (826 aa) |
| | DNAJB9 | J domain-containing protein. (216 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa) |
| | TMEM117 | Transmembrane protein 117. (512 aa) |
| | ENSGALP00000070665 | Nuclear factor, erythroid 2. (326 aa) |
| | BCL2L11 | BCL2 like 11. (179 aa) |
| | TMED2 | GOLD domain-containing protein. (208 aa) |
| | ENSGALP00000069923 | Uncharacterized protein. (357 aa) |
| | UFC1 | Uncharacterized protein. (647 aa) |
| | UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1. (1559 aa) |
| | TTC33 | Tetratricopeptide repeat domain 33. (304 aa) |
| | RNF5 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] (229 aa) |
| | MBTPS2 | Membrane bound transcription factor peptidase, site 2. (494 aa) |
| | NCK1 | Cytoplasmic protein. (380 aa) |
| | SRPX | Sushi repeat containing protein X-linked. (464 aa) |
| | P4HB | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). Also acts a structural subunit o [...] (547 aa) |
| | PMLL | Uncharacterized protein. (464 aa) |
| | PSMC6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa) |
| | ERP27 | Endoplasmic reticulum protein 27. (293 aa) |
| | UBE2J1 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (317 aa) |
| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa) |
| | TMCO1 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling. (188 aa) |
| | UBA5 | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2; Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. (394 aa) |
