(49 nodes) Multicellular organism growth network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMED2	GOLD domain-containing protein. (208 aa)
	SP2	Sp2 transcription factor. (626 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	CLIC4	Chloride intracellular channel 4. (253 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
	STK40	Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (467 aa)
	CCM2	PID domain-containing protein. (453 aa)
	PALB2	Partner and localizer of BRCA2. (1341 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa)
	ANKRD11	Ankyrin repeat domain 11. (2707 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1495 aa)
	ATRX	ATRX chromatin remodeler. (2420 aa)
	TTC8	Tetratricopeptide repeat domain 8. (567 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2644 aa)
	PKDCCB	PIP49_C domain-containing protein. (378 aa)
	IHH	Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
	EP300	E1A binding protein p300. (2450 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1166 aa)
	KDM6A	Uncharacterized protein. (1484 aa)
	SLITRK1	SLIT and NTRK like family member 1. (692 aa)
	ATM	Non-specific serine/threonine protein kinase. (3050 aa)
	WDR48	WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (678 aa)
	XRCC2	X-ray repair cross complementing 2. (279 aa)
	WDR11	WD repeat domain 11. (1222 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (662 aa)
	SLC4A10	Anion exchange protein. (1116 aa)
	AR	Uncharacterized protein. (703 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (496 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (697 aa)
	RBBP6	RB binding protein 6, ubiquitin ligase. (1967 aa)
	SMO	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
	CTC1	Uncharacterized protein. (1282 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1319 aa)
	ENSGALP00000051627	ANK_REP_REGION domain-containing protein. (323 aa)
	EN1	Homeobox protein engrailed-1. (334 aa)
	SLC1A2	Amino acid transporter. (554 aa)
	GIGYF2	GYF domain-containing protein. (1278 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
	SLITRK6	SLIT and NTRK like family member 6. (840 aa)
	STIL	STIL centriolar assembly protein. (1330 aa)
	ENSGALP00000071692	Uncharacterized protein. (105 aa)
	HOXA5	Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity); Belongs to the Antp homeobox family. (318 aa)
	FKBP8	Peptidylprolyl isomerase. (686 aa)
	SELENOM	Sep15_SelM domain-containing protein. (152 aa)
	ANKRD31	Uncharacterized protein. (1555 aa)
	PLAG1	Zinc finger protein PLAG1; Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. (501 aa)
	TAL2	TAL bHLH transcription factor 2. (117 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (824 aa)
	HELT	Helt bHLH transcription factor. (240 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	EP300	ENSGALP00000046062	ENSGALP00000019537	Uncharacterized protein.	E1A binding protein p300.	0.735
AR	WDR48	ENSGALP00000046062	ENSGALP00000030646	Uncharacterized protein.	WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.	0.526
ATM	ATRX	ENSGALP00000027660	ENSGALP00000012723	Non-specific serine/threonine protein kinase.	ATRX chromatin remodeler.	0.669
ATM	EP300	ENSGALP00000027660	ENSGALP00000019537	Non-specific serine/threonine protein kinase.	E1A binding protein p300.	0.597
ATM	PALB2	ENSGALP00000027660	ENSGALP00000009796	Non-specific serine/threonine protein kinase.	Partner and localizer of BRCA2.	0.898
ATM	WDR48	ENSGALP00000027660	ENSGALP00000030646	Non-specific serine/threonine protein kinase.	WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.	0.582
ATM	XRCC2	ENSGALP00000027660	ENSGALP00000041071	Non-specific serine/threonine protein kinase.	X-ray repair cross complementing 2.	0.775
ATRX	ATM	ENSGALP00000012723	ENSGALP00000027660	ATRX chromatin remodeler.	Non-specific serine/threonine protein kinase.	0.669
CTC1	PALB2	ENSGALP00000049175	ENSGALP00000009796	Uncharacterized protein.	Partner and localizer of BRCA2.	0.519
CTC1	STK40	ENSGALP00000049175	ENSGALP00000073093	Uncharacterized protein.	Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	0.530
ENSGALP00000051627	ENSGALP00000071692	ENSGALP00000051627	ENSGALP00000071692	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.900
ENSGALP00000071692	ENSGALP00000051627	ENSGALP00000071692	ENSGALP00000051627	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.900
EP300	AR	ENSGALP00000019537	ENSGALP00000046062	E1A binding protein p300.	Uncharacterized protein.	0.735
EP300	ATM	ENSGALP00000019537	ENSGALP00000027660	E1A binding protein p300.	Non-specific serine/threonine protein kinase.	0.597
EP300	ERCC6	ENSGALP00000019537	ENSGALP00000010093	E1A binding protein p300.	ERCC excision repair 6, chromatin remodeling factor.	0.834
EP300	KDM6A	ENSGALP00000019537	ENSGALP00000026095	E1A binding protein p300.	Uncharacterized protein.	0.487
ERCC6	EP300	ENSGALP00000010093	ENSGALP00000019537	ERCC excision repair 6, chromatin remodeling factor.	E1A binding protein p300.	0.834
FKBP8	MTOR	ENSGALP00000064961	ENSGALP00000005274	Peptidylprolyl isomerase.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.669
HELT	TAL2	ENSGALP00000069334	ENSGALP00000067202	Helt bHLH transcription factor.	TAL bHLH transcription factor 2.	0.780
IHH	SMO	ENSGALP00000018493	ENSGALP00000048984	Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family.	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).	0.915