(15 nodes) Hippo signaling network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	WWTR1	WW domain containing transcription regulator 1. (386 aa)
	MOB1B	MOB kinase activator 1B. (314 aa)
	FAT4	FAT atypical cadherin 4. (5022 aa)
	SAV1	Salvador family WW domain containing protein 1. (385 aa)
	LATS1	Large tumor suppressor kinase 1. (1137 aa)
	TEAD4	Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...] (445 aa)
	LOC421195	Uncharacterized protein. (2510 aa)
	TEAD3	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). (433 aa)
	MOB1A	MOB kinase activator 1A. (216 aa)
	STK4	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (504 aa)
	STK3	Uncharacterized protein. (490 aa)
	YAP1	Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity); Belongs to the YAP1 family. (500 aa)
	TEAD1	TEA domain-containing protein. (433 aa)
	PJA2	RING-type domain-containing protein. (695 aa)
	LATS2	Non-specific serine/threonine protein kinase. (1125 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LATS1	LATS2	ENSGALP00000020194	ENSGALP00000074005	Large tumor suppressor kinase 1.	Non-specific serine/threonine protein kinase.	0.794
LATS1	MOB1A	ENSGALP00000020194	ENSGALP00000049331	Large tumor suppressor kinase 1.	MOB kinase activator 1A.	0.993
LATS1	MOB1B	ENSGALP00000020194	ENSGALP00000018856	Large tumor suppressor kinase 1.	MOB kinase activator 1B.	0.995
LATS1	SAV1	ENSGALP00000020194	ENSGALP00000020137	Large tumor suppressor kinase 1.	Salvador family WW domain containing protein 1.	0.989
LATS1	STK3	ENSGALP00000020194	ENSGALP00000052760	Large tumor suppressor kinase 1.	Uncharacterized protein.	0.839
LATS1	STK4	ENSGALP00000020194	ENSGALP00000050899	Large tumor suppressor kinase 1.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.823
LATS1	TEAD1	ENSGALP00000020194	ENSGALP00000053977	Large tumor suppressor kinase 1.	TEA domain-containing protein.	0.882
LATS1	TEAD3	ENSGALP00000020194	ENSGALP00000046990	Large tumor suppressor kinase 1.	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity).	0.643
LATS1	TEAD4	ENSGALP00000020194	ENSGALP00000023126	Large tumor suppressor kinase 1.	Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...]	0.710
LATS1	WWTR1	ENSGALP00000020194	ENSGALP00000016933	Large tumor suppressor kinase 1.	WW domain containing transcription regulator 1.	0.913
LATS1	YAP1	ENSGALP00000020194	ENSGALP00000053936	Large tumor suppressor kinase 1.	Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity); Belongs to the YAP1 family.	0.961
LATS2	LATS1	ENSGALP00000074005	ENSGALP00000020194	Non-specific serine/threonine protein kinase.	Large tumor suppressor kinase 1.	0.794
LATS2	MOB1A	ENSGALP00000074005	ENSGALP00000049331	Non-specific serine/threonine protein kinase.	MOB kinase activator 1A.	0.980
LATS2	MOB1B	ENSGALP00000074005	ENSGALP00000018856	Non-specific serine/threonine protein kinase.	MOB kinase activator 1B.	0.964
LATS2	SAV1	ENSGALP00000074005	ENSGALP00000020137	Non-specific serine/threonine protein kinase.	Salvador family WW domain containing protein 1.	0.983
LATS2	STK3	ENSGALP00000074005	ENSGALP00000052760	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.837
LATS2	STK4	ENSGALP00000074005	ENSGALP00000050899	Non-specific serine/threonine protein kinase.	Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...]	0.816
LATS2	TEAD1	ENSGALP00000074005	ENSGALP00000053977	Non-specific serine/threonine protein kinase.	TEA domain-containing protein.	0.832
LATS2	TEAD3	ENSGALP00000074005	ENSGALP00000046990	Non-specific serine/threonine protein kinase.	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity).	0.593
LATS2	TEAD4	ENSGALP00000074005	ENSGALP00000023126	Non-specific serine/threonine protein kinase.	Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differen [...]	0.677