(49 nodes) Regulation of multicellular organism growth network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STAT5A	Signal transducer and activator of transcription. (764 aa)
	GHRH	GHRH/PACAP-like. (172 aa)
	LOC427439	Nipped-B protein. (2783 aa)
	STAT3	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
	BBS4	TPR_REGION domain-containing protein. (532 aa)
	GH	Somatotropin; Growth hormone plays an important role in growth control. (216 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1166 aa)
	EZR	Ezrin. (585 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	PRL	Prolactin. (229 aa)
	MBD5	Methyl-CpG binding domain protein 5. (1735 aa)
	PLAC8	Uncharacterized protein. (145 aa)
	LGMN	Legumain. (431 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
	MKKS	Uncharacterized protein. (570 aa)
	ADRB1	Adrenoceptor beta 1. (477 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	CREB1	cAMP response element-binding protein. (327 aa)
	DRD2	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	GHRHR	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (528 aa)
	PLAC8L1	Uncharacterized protein. (111 aa)
	APP	BPTI/Kunitz inhibitor domain-containing protein. (751 aa)
	FXN	Frataxin. (167 aa)
	GHSR	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (561 aa)
	GHR	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. (646 aa)
	CHD9	Chromodomain helicase DNA binding protein 9. (2820 aa)
	ENSGALP00000048186	Uncharacterized protein. (528 aa)
	ADRB2	Adrenoceptor beta 2. (402 aa)
	SMO	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
	LOC427025	Nipped-B protein. (2769 aa)
	HTRA2	HtrA serine peptidase 2. (200 aa)
	CHD7	Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	FTO	FTO_NTD domain-containing protein. (565 aa)
	PRLH	Uncharacterized protein. (87 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
	CSF1	Uncharacterized protein. (493 aa)
	SOCS2	Uncharacterized protein. (227 aa)
	STAT6	SH2 domain-containing protein. (183 aa)
	LOC112530959	STAT_int domain-containing protein. (392 aa)
	GAMT	RMT2 domain-containing protein. (876 aa)
	LOC107050371	Uncharacterized protein. (1015 aa)
	SGPL1	Uncharacterized protein. (574 aa)
	ENSGALP00000069955	Uncharacterized protein. (496 aa)
	GDF15	TGF_BETA_2 domain-containing protein. (614 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (455 aa)
	ADRB3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (425 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB1	ADRB2	ENSGALP00000014538	ENSGALP00000048596	Adrenoceptor beta 1.	Adrenoceptor beta 2.	0.811
ADRB1	ADRB3	ENSGALP00000014538	ENSGALP00000029364	Adrenoceptor beta 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.821
ADRB2	ADRB1	ENSGALP00000048596	ENSGALP00000014538	Adrenoceptor beta 2.	Adrenoceptor beta 1.	0.811
ADRB2	ADRB3	ENSGALP00000048596	ENSGALP00000029364	Adrenoceptor beta 2.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.823
ADRB3	ADRB1	ENSGALP00000029364	ENSGALP00000014538	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Adrenoceptor beta 1.	0.821
ADRB3	ADRB2	ENSGALP00000029364	ENSGALP00000048596	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Adrenoceptor beta 2.	0.823
APP	GHRH	ENSGALP00000036014	ENSGALP00000006088	BPTI/Kunitz inhibitor domain-containing protein.	GHRH/PACAP-like.	0.442
APP	GHSR	ENSGALP00000036014	ENSGALP00000040663	BPTI/Kunitz inhibitor domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.431
APP	PIK3CA	ENSGALP00000036014	ENSGALP00000014504	BPTI/Kunitz inhibitor domain-containing protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.516
BBS2	BBS4	ENSGALP00000057299	ENSGALP00000002771	Bardet-Biedl syndrome 2 protein homolog.	TPR_REGION domain-containing protein.	0.999
BBS2	SMO	ENSGALP00000057299	ENSGALP00000048984	Bardet-Biedl syndrome 2 protein homolog.	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).	0.643
BBS4	BBS2	ENSGALP00000002771	ENSGALP00000057299	TPR_REGION domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	SMO	ENSGALP00000002771	ENSGALP00000048984	TPR_REGION domain-containing protein.	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).	0.625
BCL2	CREB1	ENSGALP00000020984	ENSGALP00000013824	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	cAMP response element-binding protein.	0.565
BCL2	HTRA2	ENSGALP00000020984	ENSGALP00000052289	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	HtrA serine peptidase 2.	0.586
BCL2	STAT3	ENSGALP00000020984	ENSGALP00000005161	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.864
BCL2	STAT5A	ENSGALP00000020984	ENSGALP00000005182	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Signal transducer and activator of transcription.	0.603
CREB1	BCL2	ENSGALP00000013824	ENSGALP00000020984	cAMP response element-binding protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.565
CREB1	FTO	ENSGALP00000013824	ENSGALP00000057593	cAMP response element-binding protein.	FTO_NTD domain-containing protein.	0.680
CREB1	STAT3	ENSGALP00000013824	ENSGALP00000005161	cAMP response element-binding protein.	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.655