(23 nodes) Positive regulation of multicellular organism growth network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EZR	Ezrin. (585 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
	MKKS	Uncharacterized protein. (570 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	CREB1	cAMP response element-binding protein. (327 aa)
	DRD2	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	GHRHR	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
	GHRH	GHRH/PACAP-like. (172 aa)
	LOC427439	Nipped-B protein. (2783 aa)
	BBS4	TPR_REGION domain-containing protein. (532 aa)
	GH	Somatotropin; Growth hormone plays an important role in growth control. (216 aa)
	LOC107050371	Uncharacterized protein. (1015 aa)
	ENSGALP00000069955	Uncharacterized protein. (496 aa)
	CSF1	Uncharacterized protein. (493 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	CHD7	Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
	LOC427025	Nipped-B protein. (2769 aa)
	SMO	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
	ENSGALP00000048186	Uncharacterized protein. (528 aa)
	CHD9	Chromodomain helicase DNA binding protein 9. (2820 aa)
	GHR	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. (646 aa)
	GHSR	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (561 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS2	BBS4	ENSGALP00000057299	ENSGALP00000002771	Bardet-Biedl syndrome 2 protein homolog.	TPR_REGION domain-containing protein.	0.999
BBS2	SMO	ENSGALP00000057299	ENSGALP00000048984	Bardet-Biedl syndrome 2 protein homolog.	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).	0.643
BBS4	BBS2	ENSGALP00000002771	ENSGALP00000057299	TPR_REGION domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	SMO	ENSGALP00000002771	ENSGALP00000048984	TPR_REGION domain-containing protein.	Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).	0.625
BCL2	CREB1	ENSGALP00000020984	ENSGALP00000013824	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	cAMP response element-binding protein.	0.565
CREB1	BCL2	ENSGALP00000013824	ENSGALP00000020984	cAMP response element-binding protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.565
DRD2	GH	ENSGALP00000012625	ENSGALP00000000327	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	Somatotropin; Growth hormone plays an important role in growth control.	0.492
DRD2	GHRHR	ENSGALP00000012625	ENSGALP00000008360	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family.	0.400
ENSGALP00000048186	ENSGALP00000069955	ENSGALP00000048186	ENSGALP00000069955	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000048186	LOC107050371	ENSGALP00000048186	ENSGALP00000071652	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000069955	ENSGALP00000048186	ENSGALP00000069955	ENSGALP00000048186	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000069955	LOC107050371	ENSGALP00000069955	ENSGALP00000071652	Uncharacterized protein.	Uncharacterized protein.	0.900
GH	DRD2	ENSGALP00000000327	ENSGALP00000012625	Somatotropin; Growth hormone plays an important role in growth control.	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	0.492
GH	GHR	ENSGALP00000000327	ENSGALP00000046304	Somatotropin; Growth hormone plays an important role in growth control.	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily.	0.994
GH	GHRH	ENSGALP00000000327	ENSGALP00000006088	Somatotropin; Growth hormone plays an important role in growth control.	GHRH/PACAP-like.	0.877
GH	GHRHR	ENSGALP00000000327	ENSGALP00000008360	Somatotropin; Growth hormone plays an important role in growth control.	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family.	0.553
GHR	GH	ENSGALP00000046304	ENSGALP00000000327	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily.	Somatotropin; Growth hormone plays an important role in growth control.	0.994
GHR	GHRH	ENSGALP00000046304	ENSGALP00000006088	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily.	GHRH/PACAP-like.	0.443
GHR	GHRHR	ENSGALP00000046304	ENSGALP00000008360	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily.	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family.	0.521
GHRH	GH	ENSGALP00000006088	ENSGALP00000000327	GHRH/PACAP-like.	Somatotropin; Growth hormone plays an important role in growth control.	0.877