(44 nodes) Positive regulation of T cell proliferation network (Gallus gallus)

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	CD276	Uncharacterized protein. (314 aa)
	CARD11	Uncharacterized protein. (1170 aa)
	TFRC	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa)
	FADD	Fas associated via death domain. (195 aa)
	CD28	T-cell-specific surface glycoprotein CD28 homolog; Possibly involved in T-cell activation. (304 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	IL12RB2	Uncharacterized protein. (868 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
	IGFBP2	Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (311 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
	IL6ST	Glycoprotein 130. (918 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (262 aa)
	CD274	Uncharacterized protein. (471 aa)
	SYK	Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
	CD80	Uncharacterized protein. (316 aa)
	TNFSF13B	TNF family B cell activation factor; Belongs to the tumor necrosis factor family. (288 aa)
	SLC7A1	AA_permease_C domain-containing protein. (624 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	TNFRSF13C	BaffR-Tall_bind domain-containing protein. (213 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
	CD86	Uncharacterized protein. (319 aa)
	DMB1	Ig-like domain-containing protein. (310 aa)
	CD24	Uncharacterized protein. (87 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
	IGF2	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	PTPRC	Uncharacterized protein. (1237 aa)
	SASH3	Uncharacterized protein. (382 aa)
	DMB2	Ig-like domain-containing protein. (323 aa)
	K4LB56_CHICK	CD150. (333 aa)
	ENSGALP00000065981	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (164 aa)
	IL12RB1	Fibronectin type-III domain-containing protein. (591 aa)
	HHLA2	HERV-H LTR-associating 2. (364 aa)
	NCK1	Cytoplasmic protein. (380 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
	PDCD1LG2	Uncharacterized protein. (334 aa)
	CD6	Uncharacterized protein. (1081 aa)
	RIPK3	Uncharacterized protein. (424 aa)
	ENSGALP00000072274	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (126 aa)
	DHPS	Uncharacterized protein. (141 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	IL1B	ENSGALP00000032184	ENSGALP00000050171	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Interleukin-1; Belongs to the IL-1 family.	0.461
CARD11	PTPRC	ENSGALP00000007002	ENSGALP00000055398	Uncharacterized protein.	Uncharacterized protein.	0.448
CARD11	RIPK2	ENSGALP00000007002	ENSGALP00000046771	Uncharacterized protein.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.511
CARD11	SYK	ENSGALP00000007002	ENSGALP00000024509	Uncharacterized protein.	Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...]	0.614
CARD11	TNFSF13B	ENSGALP00000007002	ENSGALP00000027177	Uncharacterized protein.	TNF family B cell activation factor; Belongs to the tumor necrosis factor family.	0.420
CARD11	TRAF6	ENSGALP00000007002	ENSGALP00000068399	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.842
CARD11	ZAP70	ENSGALP00000007002	ENSGALP00000002252	Uncharacterized protein.	Tyrosine-protein kinase.	0.653
CD24	CD80	ENSGALP00000043504	ENSGALP00000024911	Uncharacterized protein.	Uncharacterized protein.	0.640
CD24	CD86	ENSGALP00000043504	ENSGALP00000036384	Uncharacterized protein.	Uncharacterized protein.	0.619
CD24	IL6	ENSGALP00000043504	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.430
CD24	K4LB56_CHICK	ENSGALP00000043504	ENSGALP00000062477	Uncharacterized protein.	CD150.	0.421
CD274	CD80	ENSGALP00000024196	ENSGALP00000024911	Uncharacterized protein.	Uncharacterized protein.	0.998
CD274	CD86	ENSGALP00000024196	ENSGALP00000036384	Uncharacterized protein.	Uncharacterized protein.	0.742
CD274	IL1B	ENSGALP00000024196	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.400
CD274	IL6	ENSGALP00000024196	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.499
CD274	PDCD1LG2	ENSGALP00000024196	ENSGALP00000070477	Uncharacterized protein.	Uncharacterized protein.	0.885
CD274	PTPRC	ENSGALP00000024196	ENSGALP00000055398	Uncharacterized protein.	Uncharacterized protein.	0.448
CD276	CD80	ENSGALP00000002650	ENSGALP00000024911	Uncharacterized protein.	Uncharacterized protein.	0.662
CD276	CD86	ENSGALP00000002650	ENSGALP00000036384	Uncharacterized protein.	Uncharacterized protein.	0.639
CD28	CD80	ENSGALP00000014099	ENSGALP00000024911	T-cell-specific surface glycoprotein CD28 homolog; Possibly involved in T-cell activation.	Uncharacterized protein.	0.993