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| | CD79B | B29/Ig-b. (226 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa) |
| | DEF6 | DEF6 guanine nucleotide exchange factor. (625 aa) |
| | ATAD5 | AAA domain-containing protein. (1816 aa) |
| | ITM2A | BRICHOS domain-containing protein. (251 aa) |
| | CARD11 | Uncharacterized protein. (1170 aa) |
| | IRF8 | Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity); Belongs to the IRF family. (425 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa) |
| | POU2AF1 | Oct binding factor 1. (256 aa) |
| | BCL6 | B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa) |
| | KIAA1841 | DUF3342 domain-containing protein. (718 aa) |
| | HSPD1 | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (942 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (286 aa) |
| | TSHR | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa) |
| | EXO1 | Uncharacterized protein. (800 aa) |
| | CMTM7 | MARVEL domain-containing protein. (174 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (145 aa) |
| | LOC768614 | Interferon type A3; Has antiviral activities; Belongs to the alpha/beta interferon family. (193 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (730 aa) |
| | CG-1B | Beta-galactoside-binding lectin; This protein binds beta-galactoside. May participate in host antiviral defense through specific interaction with glycans on the viral envelope glycoproteins. (135 aa) |
| | MFNG | Beta-1,3-N-acetylglucosaminyltransferase. (352 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | NTRK1 | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa) |
| | IL7R | Interleukin-7 receptor alpha chain. (460 aa) |
| | IKZF3 | Uncharacterized protein. (509 aa) |
| | PTPN2 | Uncharacterized protein. (597 aa) |
| | AICDA | CMP/dCMP-type deaminase domain-containing protein. (198 aa) |
| | ITFG2 | Integrin alpha FG-GAP repeat containing 2. (460 aa) |
| | GON4L | Uncharacterized protein. (1044 aa) |
| | RABL3 | Rab-like protein 3; Belongs to the small GTPase superfamily. Rab family. (236 aa) |
| | TRAF3IP2 | SEFIR domain-containing protein. (532 aa) |
| | TNFSF13B | TNF family B cell activation factor; Belongs to the tumor necrosis factor family. (288 aa) |
| | GPR183 | G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (371 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3050 aa) |
| | IFNKL1 | Uncharacterized protein. (197 aa) |
| | HDAC4 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (1080 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa) |
| | CD86 | Uncharacterized protein. (319 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (711 aa) |
| | CD180 | CD180 molecule. (708 aa) |
| | CD40 | Uncharacterized protein. (299 aa) |
| | NTN1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa) |
| | IFNW1 | Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. (203 aa) |
| | CXCR5 | Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa) |
| | LRRC8A | Leucine rich repeat containing 8 VRAC subunit A. (810 aa) |
| | CDH17 | Uncharacterized protein. (835 aa) |
| | CG-16 | 16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation. (126 aa) |
| | LFNG | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning. (363 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (529 aa) |
| | SP3 | Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa) |
| | MLH1 | DNA mismatch repair protein MLH1. (757 aa) |
| | MALT1 | MALT1 paracaspase. (816 aa) |
| | LAT2 | Linker for activation of T-cells family member 2; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2. (198 aa) |
| | NKX2-3 | Homeobox domain-containing protein. (328 aa) |
| | NKX2-6 | Homeobox domain-containing protein. (193 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa) |
| | IL7 | Interleukin-7. (146 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1505 aa) |
| | SKAP2 | Src kinase associated phosphoprotein 2. (391 aa) |
| | PCASP3 | Uncharacterized protein. (632 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (384 aa) |
| | TPD52 | Uncharacterized protein. (184 aa) |
| | FLT3 | Fms related tyrosine kinase 3. (877 aa) |
| | CEBPG | Leucine zipper transcription factor. (150 aa) |
| | BAK1 | Uncharacterized protein. (216 aa) |
| | PTPRC | Uncharacterized protein. (1237 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa) |
| | PCASP2 | Uncharacterized protein. (741 aa) |
| | SASH3 | Uncharacterized protein. (382 aa) |
| | RAG2 | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (535 aa) |
| | LOC100858506 | Interferon alpha. (193 aa) |
| | ENSGALP00000060489 | Hist_deacetyl domain-containing protein. (316 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (480 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (356 aa) |
| | ENSGALP00000065981 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (164 aa) |
| | LOC100859414 | Uncharacterized protein. (193 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa) |
| | EXOSC3 | KH_dom_type_1 domain-containing protein. (288 aa) |
| | ENSGALP00000068805 | Uncharacterized protein. (165 aa) |
| | LOC100858177 | Interferon type A1/A2; Has antiviral activities. (193 aa) |
| | LOC776018 | Uncharacterized protein. (193 aa) |
| | DOCK10 | Dedicator of cytokinesis 10; Belongs to the DOCK family. (2212 aa) |
| | IFNA3 | Interferon. (193 aa) |
| | SH2D6 | B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...] (598 aa) |
| | LOC100857744 | Interferon type A1/A2-like. (193 aa) |
| | LOC100859032 | Interferon type A1/A2-like. (193 aa) |
| | NFAM1 | Uncharacterized protein. (323 aa) |
| | LOC100857947 | Interferon type A1/A2-like. (193 aa) |
| | IRF9 | IRF tryptophan pentad repeat domain-containing protein. (472 aa) |
| | DNAJB9 | J domain-containing protein. (216 aa) |
| | LOC100857403 | Interferon type A1/A2-like. (193 aa) |
| | ENSGALP00000072274 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (126 aa) |
| | ENSGALP00000072433 | Hist_deacetyl domain-containing protein. (266 aa) |
| | LOC100858762 | Uncharacterized protein. (193 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (605 aa) |
| | LEF1 | HMG box domain-containing protein. (412 aa) |
| | TXLNA | Taxilin alpha. (546 aa) |
