STRINGSTRING
TBC1D5 TBC1D5 PLEKHJ1 PLEKHJ1 VPS51 VPS51 VPS29 VPS29 TRAPPC10 TRAPPC10 VAMP3 VAMP3 RAB7B RAB7B SNX5 SNX5 RAB6A RAB6A CLN5 CLN5 GCC2 GCC2 RAB9A RAB9A SNX3 SNX3 TBC1D23 TBC1D23 RIC1 RIC1 RHOBTB3 RHOBTB3 FAM21C FAM21C STX5 STX5 ARFRP1 ARFRP1 VPS50 VPS50 LOC112530905 LOC112530905 SNX12 SNX12 PHETA2 PHETA2 RBSN RBSN PIKFYVE PIKFYVE VPS54 VPS54 TMEM87A TMEM87A VTI1B VTI1B HEATR5B HEATR5B GOLT1A GOLT1A SLC66A2 SLC66A2 RAB41 RAB41 HEATR5A HEATR5A WASH1 WASH1 SNX1 SNX1 RAB29 RAB29 ANKFY1 ANKFY1 VPS26B VPS26B UBE2O UBE2O STX10 STX10 BET1L BET1L SNX8 SNX8 VPS35 VPS35 RAB9B RAB9B CLTC CLTC GBF1 GBF1 VPS29L VPS29L TBC1D10A TBC1D10A RGP1 RGP1 ARL1 ARL1 VPS26A VPS26A VTI1A VTI1A SNX2 SNX2 STX16 STX16 GOLT1B GOLT1B SNX32 SNX32 YKT6 YKT6 PHETA1 PHETA1 CLTCL1 CLTCL1 RNF126 RNF126 VPS53 VPS53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBC1D5TBC1 domain family member 5. (834 aa)
PLEKHJ1Pleckstrin homology domain-containing family J member 1. (149 aa)
VPS51Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. (787 aa)
VPS29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...] (185 aa)
TRAPPC10Foie-gras_1 domain-containing protein. (1267 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (397 aa)
RAB6ARas-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Belongs to the small GTPase superfamily. Rab family. (208 aa)
CLN5Uncharacterized protein. (339 aa)
GCC2GRIP and coiled-coil domain containing 2. (1693 aa)
RAB9AUncharacterized protein. (201 aa)
SNX3PX domain-containing protein. (162 aa)
TBC1D23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (By similarity). May act as a general inhibitor of innate immunity signaling (By similarity). (679 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1419 aa)
RHOBTB3Rho related BTB domain containing 3. (618 aa)
FAM21CCAP-ZIP_m domain-containing protein. (1325 aa)
STX5Syntaxin 5; Belongs to the syntaxin family. (344 aa)
ARFRP1ADP ribosylation factor related protein 1. (256 aa)
VPS50Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. (997 aa)
LOC112530905Rab-GAP TBC domain-containing protein. (1368 aa)
SNX12PX domain-containing protein. (211 aa)
PHETA2PH domain containing endocytic trafficking adaptor 2. (252 aa)
RBSNRabenosyn, RAB effector. (787 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
VPS54VPS54 subunit of GARP complex. (974 aa)
TMEM87ATransmembrane protein 87A. (528 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
HEATR5BHEAT repeat containing 5B. (2073 aa)
GOLT1AGolgi transport 1A. (138 aa)
SLC66A2Solute carrier family 66 member 2. (271 aa)
RAB41Uncharacterized protein. (211 aa)
HEATR5AHEAT repeat containing 5A. (2031 aa)
WASH1WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (485 aa)
SNX1Sorting nexin 1. (514 aa)
RAB29RAB29, member RAS oncogene family. (205 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1076 aa)
VPS26BVPS26, retromer complex component B. (336 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1374 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
BET1Lt-SNARE coiled-coil homology domain-containing protein. (111 aa)
SNX8Sorting nexin 8. (448 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (799 aa)
RAB9BRAB9B, member RAS oncogene family. (261 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1863 aa)
VPS29LVacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (232 aa)
TBC1D10ARab-GAP TBC domain-containing protein. (477 aa)
RGP1Uncharacterized protein. (470 aa)
ARL1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (231 aa)
VPS26AVPS26, retromer complex component A. (326 aa)
VTI1At-SNARE coiled-coil homology domain-containing protein. (224 aa)
SNX2PX domain-containing protein. (605 aa)
STX16t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (326 aa)
GOLT1BGolgi transport 1B. (138 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (406 aa)
YKT6Uncharacterized protein; Belongs to the synaptobrevin family. (198 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (238 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
RNF126RING-type domain-containing protein. (385 aa)
VPS53Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Acts as component of the EARP complex that is involved in endocytic recycling. (831 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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