STRINGSTRING
EDNRA EDNRA PROX1 PROX1 LRIG3 LRIG3 MYO3B MYO3B DLX5 DLX5 WDPCP WDPCP USH1C USH1C TSHR TSHR SLITRK6 SLITRK6 LOC427439 LOC427439 PRRX1 PRRX1 FRZB FRZB EEF1E1 EEF1E1 GRXCR2 GRXCR2 NKX3-2 NKX3-2 TPRN TPRN ENSGALP00000066624 ENSGALP00000066624 REST REST ENSGALP00000068651 ENSGALP00000068651 GATA3 GATA3 CTHRC1 CTHRC1 ENSGALP00000069955 ENSGALP00000069955 DLX6 DLX6 KCNQ1 KCNQ1 WHRN WHRN LOC107050371 LOC107050371 OSR1 OSR1 OTX1 OTX1 PTPRQ PTPRQ EDN1 EDN1 IGF1 IGF1 E1C1Y1_CHICK E1C1Y1_CHICK MSX1 MSX1 TTC39C TTC39C MYO6 MYO6 PDZD7 PDZD7 LRRC1 LRRC1 SIX4 SIX4 FGF8 FGF8 LRIG1 LRIG1 SOX9 SOX9 PDZD7-2 PDZD7-2 NTN1 NTN1 SIX2 SIX2 FZD3 FZD3 NAGLU NAGLU TBX3 TBX3 USH1G USH1G SIX1 SIX1 CHD9 CHD9 OSR2 OSR2 ENSGALP00000048186 ENSGALP00000048186 SOX21 SOX21 OTOP1 OTOP1 SEC24B SEC24B EYA1 EYA1 LOC427025 LOC427025 GBX2 GBX2 ZIC1 ZIC1 FOXG1 FOXG1 SOBP SOBP ALDH1A3 ALDH1A3 MYO3A MYO3A CHD7 CHD7 WNT3A WNT3A CLRN1 CLRN1 TBX2 TBX2 NBL1 NBL1 WDR19 WDR19 GSC GSC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
PROX1Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa)
LRIG3Uncharacterized protein. (1099 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1287 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
WDPCPWD repeat containing planar cell polarity effector. (807 aa)
USH1CUSH1 protein network component harmonin. (556 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
SLITRK6SLIT and NTRK like family member 6. (840 aa)
LOC427439Nipped-B protein. (2783 aa)
PRRX1Paired mesoderm homeobox protein 1; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face. (245 aa)
FRZBSecreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (315 aa)
EEF1E1Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking (By similarity); Belongs to the BLOC1S5 family. (221 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (132 aa)
NKX3-2Homeobox domain-containing protein. (275 aa)
TPRNPhostensin domain-containing protein. (125 aa)
ENSGALP00000066624Uncharacterized protein. (187 aa)
RESTUncharacterized protein. (339 aa)
ENSGALP00000068651Uncharacterized protein. (150 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
CTHRC1Collagen triple helix repeat containing 1. (314 aa)
ENSGALP00000069955Uncharacterized protein. (496 aa)
DLX6Homeobox domain-containing protein. (283 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
WHRNWhirlin. (926 aa)
LOC107050371Uncharacterized protein. (1015 aa)
OSR1Uncharacterized protein. (260 aa)
OTX1Orthodenticle homeobox 1. (335 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2308 aa)
EDN1Endothelin 1. (194 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
E1C1Y1_CHICKUncharacterized protein. (351 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
TTC39CTetratricopeptide repeat domain 39C. (576 aa)
MYO6Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-su [...] (1276 aa)
PDZD7PDZ domain-containing protein. (413 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
SIX4SIX homeobox 4. (776 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1206 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
PDZD7-2Uncharacterized protein. (548 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa)
SIX2Sine oculis-related homeobox 2 homolog. (287 aa)
FZD3Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (751 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
USH1GUSH1 protein network component sans. (457 aa)
SIX1Sine oculis-related homeobox 1 homolog. (282 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2820 aa)
OSR2Uncharacterized protein. (412 aa)
ENSGALP00000048186Uncharacterized protein. (528 aa)
SOX21Transcription factor SOX-21; Acts as a negative regulator of transcription. (280 aa)
OTOP1Otopetrin 1. (609 aa)
SEC24BUncharacterized protein. (1234 aa)
EYA1Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa)
LOC427025Nipped-B protein. (2769 aa)
GBX2Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa)
ZIC1Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). (444 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
SOBPSine oculis-binding protein homolog; Implicated in development of the cochlea. (873 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1632 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
WNT3AProtein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa)
CLRN1Clarin 1. (232 aa)
TBX2T-box transcription factor 2. (693 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor. (194 aa)
WDR19WD_REPEATS_REGION domain-containing protein. (470 aa)
GSCHomeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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