STRINGSTRING
RFX6 RFX6 RPS6 RPS6 ZBTB20 ZBTB20 WFS1 WFS1 FGFR4 FGFR4 GCLC GCLC CPB2 CPB2 MTNR1B MTNR1B LEPR LEPR GCG GCG LRRC8D LRRC8D KCNB1 KCNB1 IGFBP5 IGFBP5 APPL2 APPL2 ADIPOR2 ADIPOR2 LRRC8A LRRC8A GAS6 GAS6 DBH DBH MLXIPL MLXIPL PARK7 PARK7 BHLHA15 BHLHA15 HECTD4 HECTD4 SESN2 SESN2 GCK GCK LOC100859819 LOC100859819 CYP7A1 CYP7A1 PDX1 PDX1 ADCY8 ADCY8 FABP5 FABP5 HK3 HK3 STK11 STK11 CARTPT CARTPT PRCP PRCP WISP1 WISP1 HNF1A HNF1A GPI GPI SIRT6 SIRT6 ASPSCR1 ASPSCR1 STXBP3 STXBP3 NUCKS1 NUCKS1 CYB5R4 CYB5R4 NOX4 NOX4 HK2 HK2 IL6 IL6 FFAR2L FFAR2L HIF3A HIF3A CRTC2 CRTC2 SUCNR1 SUCNR1 NR1D1 NR1D1 LOC107050658 LOC107050658 GPR1 GPR1 PCK2 PCK2 DHPS DHPS RPH3AL RPH3AL ADGRF5 ADGRF5 RBP4A RBP4A NCOA5 NCOA5 PCK1 PCK1 SLC37A4 SLC37A4 KLF7 KLF7 NEUROD1 NEUROD1 PIK3CA PIK3CA TRA2B TRA2B CCDC186 CCDC186 RAB11FIP2 RAB11FIP2 SELENOT SELENOT PRKAA2 PRKAA2 NR1H4 NR1H4 HIF1A HIF1A MBD5 MBD5 ZNF236 ZNF236 PTPN2 PTPN2 ADIPOR1 ADIPOR1 FOXK2 FOXK2 INPP5K INPP5K SIRT1 SIRT1 STAT3 STAT3 CSRP3 CSRP3 GPER1 GPER1 HKDC1 HKDC1 HK1 HK1 FOXK1 FOXK1 FBN1 FBN1 ADIPOQ ADIPOQ XBP1 XBP1 ABCC8 ABCC8 PRKAA1 PRKAA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFX6Regulatory factor X6. (916 aa)
RPS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ZBTB20Zinc finger and BTB domain containing 20. (669 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
FGFR4Fibroblast growth factor receptor. (803 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
CPB2Carboxypeptidase B2. (421 aa)
MTNR1BMelatonin receptor type 1B; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (361 aa)
LEPRUncharacterized protein. (1148 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (856 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (863 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
ADIPOR2Uncharacterized protein. (386 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
GAS6Growth arrest specific 6. (667 aa)
DBHDopamine beta-hydroxylase. (584 aa)
MLXIPLBHLH domain-containing protein. (895 aa)
PARK7Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
BHLHA15Basic helix-loop-helix family member a15. (166 aa)
HECTD4HECT domain E3 ubiquitin protein ligase 4. (4408 aa)
SESN2Uncharacterized protein. (474 aa)
GCKPhosphotransferase. (465 aa)
LOC100859819CARTL. (113 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
PDX1Homeobox domain-containing protein. (259 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (291 aa)
HK3Hexokinase 3. (950 aa)
STK11Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity). (426 aa)
CARTPTCART prepropeptide. (111 aa)
PRCPProlylcarboxypeptidase. (483 aa)
WISP1Uncharacterized protein. (359 aa)
HNF1AHepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator. Belongs to the HNF1 homeobox family. (634 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
ASPSCR1ASPSCR1 tether for SLC2A4, UBX domain containing. (584 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
NUCKS1Uncharacterized protein. (355 aa)
CYB5R4Cytochrome b5 reductase 4. (523 aa)
NOX4FAD-binding FR-type domain-containing protein. (639 aa)
HK2Uncharacterized protein. (1245 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
FFAR2LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (367 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (458 aa)
CRTC2TORC_N domain-containing protein. (320 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (317 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (678 aa)
LOC107050658Free fatty acid receptor 2-like. (367 aa)
GPR1G protein-coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. (414 aa)
DHPSUncharacterized protein. (141 aa)
RPH3ALUncharacterized protein. (295 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1342 aa)
RBP4ARetinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (196 aa)
NCOA5Nuclear receptor coactivator 5. (715 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
KLF7Uncharacterized protein. (296 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TRA2BTransformer-2 beta. (289 aa)
CCDC186Coiled-coil domain containing 186. (919 aa)
RAB11FIP2RAB11 family interacting protein 2. (510 aa)
SELENOTThioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. Selenoprotein T subfamily. (199 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NR1H4Farnesoid X receptor. (473 aa)
HIF1AHypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
MBD5Methyl-CpG binding domain protein 5. (1735 aa)
ZNF236Zinc finger protein 236. (1918 aa)
PTPN2Uncharacterized protein. (597 aa)
ADIPOR1Uncharacterized protein. (479 aa)
FOXK2Forkhead box K2. (653 aa)
INPP5KIPPc domain-containing protein. (465 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
CSRP3Uncharacterized protein. (194 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Uncharacterized protein. (780 aa)
FOXK1Forkhead box K1. (600 aa)
FBN1Fibrillin 1. (2861 aa)
ADIPOQC1q domain-containing protein. (244 aa)
XBP1BZIP domain-containing protein. (372 aa)
ABCC8ATP binding cassette subfamily C member 8. (1595 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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