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| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa) |
| | VCP | Valosin containing protein. (806 aa) |
| | UBE2J2 | Ubiquitin conjugating enzyme E2 J2. (259 aa) |
| | FBXL20 | F-box and leucine rich repeat protein 20. (436 aa) |
| | RNF122 | Ring finger protein 122. (155 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | HERPUD1 | Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (322 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (924 aa) |
| | CDC27 | Uncharacterized protein. (833 aa) |
| | CCDC47 | Coiled-coil domain containing 47. (481 aa) |
| | FBXL17 | F-box and leucine rich repeat protein 17. (442 aa) |
| | PSMF1 | Uncharacterized protein. (271 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (481 aa) |
| | BFAR | Bifunctional apoptosis regulator. (449 aa) |
| | CDC20B | Cell division cycle 20B. (403 aa) |
| | ENSGALP00000069923 | Uncharacterized protein. (357 aa) |
| | FBXO45 | F-box protein 45. (107 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1758 aa) |
| | TBX21 | T-box transcription factor 21. (580 aa) |
| | FBXL12 | Uncharacterized protein. (471 aa) |
| | LOC112531384 | AAA_lid_3 domain-containing protein. (110 aa) |
| | PSMC5 | AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa) |
| | ENSGALP00000070665 | Nuclear factor, erythroid 2. (326 aa) |
| | GID4 | GID complex subunit 4 homolog. (399 aa) |
| | ANAPC10 | DOC domain-containing protein. (255 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa) |
| | RNF4 | RING-type domain-containing protein. (194 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa) |
| | DNAJB9 | J domain-containing protein. (216 aa) |
| | ENSGALP00000071775 | RING-type domain-containing protein. (343 aa) |
| | CDC26 | Uncharacterized protein. (84 aa) |
| | ENSGALP00000072290 | WD_REPEATS_REGION domain-containing protein. (89 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (723 aa) |
| | KLHDC3 | Kelch domain containing 3. (382 aa) |
| | FBXO41 | F-box protein 41. (795 aa) |
| | ENSGALP00000073564 | Uncharacterized protein. (243 aa) |
| | ANKRD46 | Ankyrin repeat domain 46. (228 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa) |
| | WDR26 | WD repeat domain 26. (648 aa) |
| | NFE2L2 | BZIP domain-containing protein. (593 aa) |
| | CANX | Uncharacterized protein. (601 aa) |
| | EDEM3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (933 aa) |
| | CUL2 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa) |
| | FBXL2 | F-box and leucine rich repeat protein 2. (436 aa) |
| | ECRG4 | ECRG4 augurin precursor. (112 aa) |
| | UBXN2A | Uncharacterized protein. (290 aa) |
| | FBXW7 | Uncharacterized protein. (586 aa) |
| | MAN1B1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (655 aa) |
| | CCNF | Cyclin F; Belongs to the cyclin family. (750 aa) |
| | SGTA | TPR_REGION domain-containing protein. (312 aa) |
| | DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa) |
| | WWP1 | E3 ubiquitin-protein ligase. (922 aa) |
| | ANAPC4 | Anaphase promoting complex subunit 4. (838 aa) |
| | UBE2A | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | RNF121 | Ring finger protein 121. (336 aa) |
| | RHBDD2 | Rhomboid domain-containing protein. (375 aa) |
| | ENSGALP00000049125 | Uncharacterized protein. (111 aa) |
| | ENSGALP00000049065 | Uncharacterized protein; Belongs to the AAA ATPase family. (448 aa) |
| | TRIP4 | Thyroid hormone receptor interactor 4. (581 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (874 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (504 aa) |
| | ECPAS | Ecm29 proteasome adaptor and scaffold. (1872 aa) |
| | AKIRIN2 | Akirin. (191 aa) |
| | LTN1 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family. (1770 aa) |
| | RNF103 | RING-type domain-containing protein. (684 aa) |
| | RMND5A | Uncharacterized protein. (391 aa) |
| | FBXO9 | F-box domain-containing protein. (435 aa) |
| | PBK | Protein kinase domain-containing protein. (322 aa) |
| | CDC16 | TPR_REGION domain-containing protein. (623 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (767 aa) |
| | KLHL42 | Kelch like family member 42. (503 aa) |
| | LOC419074 | Uncharacterized protein. (765 aa) |
| | TRIM71 | E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development. Belongs to the TRIM/RBCC family. (877 aa) |
| | UBE3D | Ubiquitin protein ligase E3D. (516 aa) |
| | EPM2A | Laforin. (319 aa) |
| | FBXO48 | F-box protein 48. (155 aa) |
| | KLHDC2 | Uncharacterized protein. (407 aa) |
| | UFD1L | Ubiquitin fusion-degradation 1-like protein. (307 aa) |
| | FZR1 | WD_REPEATS_REGION domain-containing protein. (493 aa) |
| | PSMC3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa) |
| | PELI3 | Uncharacterized protein. (418 aa) |
| | UBXN10 | UBX domain protein 10. (326 aa) |
| | UBE2G1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | FEM1A | Fem-1 homolog A. (765 aa) |
| | SELENOS | Uncharacterized protein. (207 aa) |
| | PSMD12 | PCI domain-containing protein. (456 aa) |
| | ANKRD9 | Ankyrin repeat domain 9. (292 aa) |
| | MARCHF6 | Membrane associated ring-CH-type finger 6. (921 aa) |
| | FBXO4 | F-box protein 4. (354 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (878 aa) |
| | LOC107055431 | Uncharacterized protein. (970 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa) |
| | ARMC8 | Uncharacterized protein. (673 aa) |
| | ENSGALP00000054501 | Uncharacterized protein. (152 aa) |
| | FBXO2 | F-box protein 2. (247 aa) |
| | FBXO22 | FIST_C domain-containing protein. (393 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (406 aa) |
| | FBXL7 | F-box and leucine rich repeat protein 7. (491 aa) |
| | FBXO39 | F-box protein 39. (402 aa) |
| | ZNRF2 | Zinc and ring finger 2. (232 aa) |
| | ENSGALP00000052647 | HECT domain-containing protein. (283 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (955 aa) |
| | KLHL15 | Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. (604 aa) |
| | FAM89A | Family with sequence similarity 89 member A. (136 aa) |
| | ENSGALP00000051793 | Uncharacterized protein. (360 aa) |
| | FAM8A1 | Family with sequence similarity 8 member A1. (160 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (883 aa) |
| | UBE2H | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | DDIT3 | C/EBP-like protein. (155 aa) |
| | YOD1 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (346 aa) |
| | UBE4A | U-box domain-containing protein. (1074 aa) |
| | UBE2W | UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (793 aa) |
| | HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1636 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (362 aa) |
| | TRIM2 | Uncharacterized protein. (744 aa) |
| | TTC33 | Tetratricopeptide repeat domain 33. (304 aa) |
| | SPSB1 | SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa) |
| | FBXL3 | F-box and leucine rich repeat protein 3. (433 aa) |
| | FBXL22 | F-box and leucine rich repeat protein 22. (226 aa) |
| | TRIP12 | Thyroid hormone receptor interactor 12. (2060 aa) |
| | ATXN3L | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By [...] (375 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (268 aa) |
| | DCAF11 | Uncharacterized protein. (92 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa) |
| | UBXN7 | UBX domain protein 7. (623 aa) |
| | FBXW9 | F-box domain-containing protein. (337 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (400 aa) |
| | FBXO31 | F-box protein 31. (573 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1948 aa) |
| | TRIM3 | Tripartite motif containing 3. (862 aa) |
| | UBXN11 | UBX domain protein 11. (370 aa) |
| | SPOPL | Speckle type BTB/POZ protein like. (392 aa) |
| | RNF34 | RING-type domain-containing protein. (359 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) |
| | NHLRC3 | NHL repeat containing 3. (502 aa) |
| | ASCC2 | Activating signal cointegrator 1 complex subunit 2. (753 aa) |
| | AMN1 | Antagonist of mitotic exit network 1 homolog. (266 aa) |
| | LOC107051165 | Uncharacterized protein. (230 aa) |
| | ENSGALP00000065343 | F-box domain-containing protein. (314 aa) |
| | FBXL15 | F-box and leucine rich repeat protein 15. (299 aa) |
| | UBE2G2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (165 aa) |
| | ZNF598 | Zinc finger protein 598. (877 aa) |
| | APPBP2 | TPR_REGION domain-containing protein. (586 aa) |
| | KCTD10 | Potassium channel tetramerization domain containing 10. (313 aa) |
| | ZSWIM8 | SWIM-type domain-containing protein. (1833 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (744 aa) |
| | RNF216 | Ring finger protein 216. (904 aa) |
| | FBXO38 | F-box protein 38. (1186 aa) |
| | DNAJB12 | J domain-containing protein. (374 aa) |
| | UBXN2B | UBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (402 aa) |
| | CALR | Calreticulin. (416 aa) |
| | RNF126 | RING-type domain-containing protein. (385 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | CTNNB1 | Uncharacterized protein. (781 aa) |
| | FAF1 | Fas associated factor 1. (650 aa) |
| | FBXW11 | Uncharacterized protein. (531 aa) |
| | AREL1 | Apoptosis resistant E3 ubiquitin protein ligase 1. (840 aa) |
| | USP19 | Ubiquitin specific peptidase 19. (1434 aa) |
| | SIRT2 | Deacetylase sirtuin-type domain-containing protein. (485 aa) |
| | AMFR | Autocrine motility factor receptor. (622 aa) |
| | ZFAND2A | Zinc finger AN1-type containing 2A. (175 aa) |
| | EDEM2 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (601 aa) |
| | TRPC4AP | Uncharacterized protein. (771 aa) |
| | FBXL8 | F-box domain-containing protein. (379 aa) |
| | ERLIN1 | PHB domain-containing protein. (347 aa) |
| | FAF2 | Fas associated factor family member 2. (445 aa) |
| | SKP2 | F-box domain-containing protein. (520 aa) |
| | SMURF2 | SMAD specific E3 ubiquitin protein ligase 2. (717 aa) |
| | FBXO42 | F-box protein 42. (764 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (565 aa) |
| | CALR3 | Calreticulin. (420 aa) |
| | NEDD4 | E3 ubiquitin-protein ligase. (932 aa) |
| | FBXL18 | F-box domain-containing protein. (711 aa) |
| | FBXW5 | Uncharacterized protein. (588 aa) |
| | FBXL4 | F-box and leucine rich repeat protein 4. (620 aa) |
| | SPSB4 | SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa) |
| | SPOP | Speckle type BTB/POZ protein. (374 aa) |
| | TMEM67 | Transmembrane protein 67. (976 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | ZNRF1 | Zinc and ring finger 1. (337 aa) |
| | PSMD4 | VWFA domain-containing protein. (376 aa) |
| | SIAH3 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (242 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | FEM1B | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity); Belongs to the fem-1 family. (627 aa) |
| | ASCC3 | Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. (2211 aa) |
| | HACE1 | E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. (942 aa) |
| | PCNP | Uncharacterized protein. (178 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase. (466 aa) |
| | SGTB | TPR_REGION domain-containing protein. (304 aa) |
| | FBXL5 | F-box and leucine rich repeat protein 5. (837 aa) |
| | DNAJB14 | J domain-containing protein. (380 aa) |
| | SEC61B | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa) |
| | MAEA | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] (396 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (386 aa) |
| | FOXRED2 | FAD dependent oxidoreductase domain containing 2. (680 aa) |
| | TRIM9 | Tripartite motif containing 9. (802 aa) |
| | NEMF | Uncharacterized protein. (1071 aa) |
| | UBXN4 | Uncharacterized protein. (216 aa) |
| | JKAMP | Uncharacterized protein. (314 aa) |
| | STT3B | Uncharacterized protein. (801 aa) |
| | ANKZF1 | Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (717 aa) |
| | PSMD14 | MPN domain-containing protein. (310 aa) |
| | ASB2 | Ankyrin repeat and SOCS box containing 2. (645 aa) |
| | PSMC1 | 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. (529 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (319 aa) |
| | HECTD3 | Uncharacterized protein. (845 aa) |
| | LOC424588 | Uncharacterized protein. (887 aa) |
| | FBXO33 | F-box protein 33. (526 aa) |
| | CDC20 | WD_REPEATS_REGION domain-containing protein. (507 aa) |
| | HECTD1 | HECT domain E3 ubiquitin protein ligase 1. (2570 aa) |
| | DTL | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (720 aa) |
| | CLGN | Calmegin. (655 aa) |
| | UBR3 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1070 aa) |
| | UBR1 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1809 aa) |
| | ANKRD9L | ANK_REP_REGION domain-containing protein. (293 aa) |
| | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10. (797 aa) |
| | EDEM1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (616 aa) |
| | CRBN | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (445 aa) |
| | FEM1C | Fem-1 homolog C. (617 aa) |
| | ERLEC1 | Endoplasmic reticulum lectin 1. (452 aa) |
| | KLHDC10 | Kelch domain containing 10. (409 aa) |
| | HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1566 aa) |
| | KCTD2 | BTB domain-containing protein. (332 aa) |
| | CDC23 | Cell division cycle 23. (595 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa) |
| | KLHL22 | BTB domain-containing protein. (638 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | NSFL1C | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (379 aa) |
| | DCAF12L2 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (427 aa) |
| | NEDD4L | Uncharacterized protein. (1267 aa) |
| | RFFL | RING-type domain-containing protein. (360 aa) |
| | KCTD17 | Potassium channel tetramerization domain containing 17. (223 aa) |
| | PMLL | Uncharacterized protein. (464 aa) |
| | PSMC6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa) |
| | PLAA | Phospholipase A2 activating protein. (794 aa) |
| | ENSGALP00000062654 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (352 aa) |
| | FBXL13 | Uncharacterized protein. (439 aa) |
| | UBE2J1 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (317 aa) |
| | KLHDC1 | Kelch domain containing 1. (404 aa) |
| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa) |
| | ENSGALP00000059206 | Uncharacterized protein. (64 aa) |
| | UBE2K | Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | FBXL14 | F-box and leucine rich repeat protein 14. (400 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). (613 aa) |
| | LOC430766 | Uncharacterized protein; Belongs to the AAA ATPase family. (820 aa) |
| | STUB1 | STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Mediates polyubiquitination of DNA polymerase beta (POLB), thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. May ubiquitinate EPHA2 and regulate the receptor stability and activity through proteasomal degradation. (314 aa) |
| | LOC100858626 | Zinc finger AN1-type containing 2B. (488 aa) |
| | DERL2 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa) |
| | FBXO44 | Uncharacterized protein. (304 aa) |
| | GSE1 | Gse1 coiled-coil protein. (1169 aa) |
| | GID8 | Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. (228 aa) |
| | ERLIN2 | ER lipid raft associated 2. (342 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) |
| | UBE4B | Ubiquitination factor E4B. (1346 aa) |
| | DNAJC18 | J domain-containing protein. (296 aa) |
| | FBXL16 | Uncharacterized protein. (503 aa) |
| | SPSB3 | SplA/ryanodine receptor domain and SOCS box containing 3. (389 aa) |
