(18 nodes) Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VPS25	Vacuolar protein sorting 25 homolog. (174 aa)
	VPS4A	Uncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
	RNF126	RING-type domain-containing protein. (385 aa)
	VPS37C	VPS37 C-terminal domain-containing protein. (370 aa)
	PLAA	Phospholipase A2 activating protein. (794 aa)
	RNF115	RING-type domain-containing protein. (522 aa)
	VPS37D	VPS37D subunit of ESCRT-I. (358 aa)
	CHMP3	Uncharacterized protein. (241 aa)
	VPS37A	VPS37A subunit of ESCRT-I. (395 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	VPS37B	VPS37B subunit of ESCRT-I. (283 aa)
	TSG101	Uncharacterized protein. (390 aa)
	UBAP1L	Uncharacterized protein. (428 aa)
	VPS4B	Uncharacterized protein; Belongs to the AAA ATPase family. (438 aa)
	CHMP5	Uncharacterized protein. (219 aa)
	VPS36	Vacuolar protein sorting 36 homolog. (541 aa)
	UBAP1	Ubiquitin associated protein 1. (515 aa)
	STAM	Signal transducing adaptor molecule. (522 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP3	CHMP5	ENSGALP00000070780	ENSGALP00000021459	Uncharacterized protein.	Uncharacterized protein.	0.970
CHMP3	SNF8	ENSGALP00000070780	ENSGALP00000001991	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.848
CHMP3	STAM	ENSGALP00000070780	ENSGALP00000043582	Uncharacterized protein.	Signal transducing adaptor molecule.	0.740
CHMP3	TSG101	ENSGALP00000070780	ENSGALP00000010193	Uncharacterized protein.	Uncharacterized protein.	0.866
CHMP3	UBAP1	ENSGALP00000070780	ENSGALP00000033856	Uncharacterized protein.	Ubiquitin associated protein 1.	0.540
CHMP3	UBAP1L	ENSGALP00000070780	ENSGALP00000011852	Uncharacterized protein.	Uncharacterized protein.	0.540
CHMP3	VPS25	ENSGALP00000070780	ENSGALP00000044578	Uncharacterized protein.	Vacuolar protein sorting 25 homolog.	0.821
CHMP3	VPS36	ENSGALP00000070780	ENSGALP00000027458	Uncharacterized protein.	Vacuolar protein sorting 36 homolog.	0.922
CHMP3	VPS37A	ENSGALP00000070780	ENSGALP00000072630	Uncharacterized protein.	VPS37A subunit of ESCRT-I.	0.701
CHMP3	VPS37B	ENSGALP00000070780	ENSGALP00000005929	Uncharacterized protein.	VPS37B subunit of ESCRT-I.	0.936
CHMP3	VPS37C	ENSGALP00000070780	ENSGALP00000051299	Uncharacterized protein.	VPS37 C-terminal domain-containing protein.	0.676
CHMP3	VPS37D	ENSGALP00000070780	ENSGALP00000069540	Uncharacterized protein.	VPS37D subunit of ESCRT-I.	0.676
CHMP3	VPS4A	ENSGALP00000070780	ENSGALP00000045396	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.861
CHMP3	VPS4B	ENSGALP00000070780	ENSGALP00000020977	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.836
CHMP5	CHMP3	ENSGALP00000021459	ENSGALP00000070780	Uncharacterized protein.	Uncharacterized protein.	0.970
CHMP5	SNF8	ENSGALP00000021459	ENSGALP00000001991	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.408
CHMP5	STAM	ENSGALP00000021459	ENSGALP00000043582	Uncharacterized protein.	Signal transducing adaptor molecule.	0.672
CHMP5	TSG101	ENSGALP00000021459	ENSGALP00000010193	Uncharacterized protein.	Uncharacterized protein.	0.574
CHMP5	VPS25	ENSGALP00000021459	ENSGALP00000044578	Uncharacterized protein.	Vacuolar protein sorting 25 homolog.	0.628
CHMP5	VPS36	ENSGALP00000021459	ENSGALP00000027458	Uncharacterized protein.	Vacuolar protein sorting 36 homolog.	0.628