STRINGSTRING
LOC112530485 LOC112530485 PAK1 PAK1 HSPA5 HSPA5 ARPC5L ARPC5L TBCD TBCD CAMSAP1 CAMSAP1 BBS4 BBS4 TPPP3 TPPP3 TMOD1 TMOD1 CAMSAP2 CAMSAP2 KIF14 KIF14 GBA2 GBA2 ATR ATR MYL1 MYL1 MTOR MTOR BAIAP2L1 BAIAP2L1 FBLIM1 FBLIM1 RICTOR RICTOR DKK1 DKK1 CYFIP2 CYFIP2 ARPC3 ARPC3 LOC419677 LOC419677 CAPZB CAPZB TRAF3IP1 TRAF3IP1 SAR1A SAR1A TMOD3 TMOD3 TFIP11 TFIP11 VILL VILL MLST8 MLST8 MAPRE1 MAPRE1 TLR4 TLR4 CRYAB CRYAB SLF2 SLF2 PAK3 PAK3 NAPB NAPB HRG HRG LMOD2 LMOD2 FERMT1 FERMT1 MKKS MKKS PFN3 PFN3 ZNF827 ZNF827 KANK1 KANK1 CXCL13L2 CXCL13L2 EIF2AK2 EIF2AK2 SCIN SCIN EVL EVL WARS1 WARS1 ARPC2 ARPC2 PPM1A PPM1A EP300 EP300 BAIAP2L2 BAIAP2L2 LATS1 LATS1 TUBB2B TUBB2B RDX RDX CAPZA3 CAPZA3 SNX9 SNX9 CDT1 CDT1 ARHGAP28 ARHGAP28 CLUL1 CLUL1 RIOK3 RIOK3 IMPACT IMPACT RASA1 RASA1 ADD1 ADD1 TRAPPC12 TRAPPC12 CYFIP1 CYFIP1 DNAJC15 DNAJC15 ATM ATM ARHGEF5 ARHGEF5 RPS3 RPS3 COTL1 COTL1 LMOD3 LMOD3 PFN4 PFN4 SVIP SVIP LCMT1 LCMT1 CARMIL2 CARMIL2 SSH2 SSH2 ANKRA2 ANKRA2 DRG1 DRG1 AMBRA1 AMBRA1 CDC42EP4 CDC42EP4 SOX9 SOX9 AIDA AIDA ARPC5 ARPC5 HSPB1 HSPB1 ARPC1A ARPC1A TMEM130 TMEM130 KANK3 KANK3 TMSB4X TMSB4X LMOD1 LMOD1 ARF6 ARF6 AKAIN1 AKAIN1 BMF BMF ANKRD27 ANKRD27 TWF1 TWF1 NAPA NAPA CDH17 CDH17 NLRC3 NLRC3 SLIT2 SLIT2 FAF1 FAF1 MSN MSN TMSB15B TMSB15B SENP6 SENP6 BAIAP2 BAIAP2 PMEPA1 PMEPA1 PINK1 PINK1 TPPP TPPP OPRD1 OPRD1 CDC42EP1 CDC42EP1 ARFGEF1 ARFGEF1 NUMA1 NUMA1 LOC100859468 LOC100859468 CAPG CAPG FAM49A FAM49A SMAD6 SMAD6 ENSGALP00000050074 ENSGALP00000050074 FLII FLII ARPC1B ARPC1B HIP1R HIP1R ADD2 ADD2 ENSGALP00000051793 ENSGALP00000051793 CXCL13L3 CXCL13L3 ULK1 ULK1 SOST SOST CDK5RAP2 CDK5RAP2 TWF2 TWF2 TBX20 TBX20 C15orf62 C15orf62 SPTBN1 SPTBN1 C7orf73 C7orf73 HCLS1 HCLS1 GSN GSN MET MET FARP2 FARP2 HJURP HJURP PRUNE1 PRUNE1 LGALS3 LGALS3 BAK1 BAK1 SAR1B SAR1B ENSGALP00000055818 ENSGALP00000055818 BBS10 BBS10 STMN2 STMN2 ARHGAP18 ARHGAP18 CARMIL1 CARMIL1 MTPN MTPN FERMT2 FERMT2 LOC421441 LOC421441 NCKAP1L NCKAP1L FCHSD2 FCHSD2 NOP53 NOP53 CAPZA2 CAPZA2 CAPZA1 CAPZA1 TMOD2 TMOD2 TENM1 TENM1 DBN1 DBN1 TOGARAM1 TOGARAM1 HSF1 HSF1 VIL1 VIL1 FES FES DHX33 DHX33 ENSGALP00000060289 ENSGALP00000060289 ENSGALP00000060643 ENSGALP00000060643 STMN1 STMN1 ENSGALP00000061073 ENSGALP00000061073 TIRAP TIRAP PSMC6 PSMC6 CXCL13 CXCL13 PTGER4 PTGER4 ENSGALP00000065294 ENSGALP00000065294 LOC107049673 LOC107049673 FAM49B FAM49B PLEK PLEK PDE4DIP PDE4DIP JAM3 JAM3 CDC42 CDC42 DMTN DMTN SPTBN4L SPTBN4L DBNL DBNL SPTAN1 SPTAN1 VEGFA VEGFA STXBP6 STXBP6 FNIP2 FNIP2 ENSGALP00000066829 ENSGALP00000066829 NCK1 NCK1 CLIP1 CLIP1 TTBK1 TTBK1 ENSGALP00000067665 ENSGALP00000067665 INPP5J-2 INPP5J-2 ICE1 ICE1 TPPP2 TPPP2 SLAIN2 SLAIN2 CCL19 CCL19 FER FER ENSGALP00000068509 ENSGALP00000068509 LOC101752211 LOC101752211 ENSGALP00000069115 ENSGALP00000069115 SPTBN5 SPTBN5 HAX1 HAX1 ELN ELN ARHGAP40 ARHGAP40 SVIL SVIL LOC107056280 LOC107056280 FAM178B FAM178B TRARG1 TRARG1 SPTBN2 SPTBN2 SPIDR SPIDR SLF1 SLF1 ADD3 ADD3 LOC107050229 LOC107050229 MECP2 MECP2 ARPC4 ARPC4 ENSGALP00000070586 ENSGALP00000070586 BCL2L11 BCL2L11 CTTN CTTN CKAP5 CKAP5 ENSGALP00000071066 ENSGALP00000071066 CRACD CRACD USP50 USP50 ENSGALP00000071309 ENSGALP00000071309 KANK4 KANK4 LOC107050733 LOC107050733 TMSB4Y TMSB4Y TMOD4 TMOD4 KIF9 KIF9 SLC39A12 SLC39A12 RNF4 RNF4 FCHSD1 FCHSD1 WNT1 WNT1 CDC42EP3 CDC42EP3 SKAP1 SKAP1 ENSGALP00000072279 ENSGALP00000072279 CTNNBIP1 CTNNBIP1 MAP2 MAP2 ENSGALP00000072464 ENSGALP00000072464 MAPT MAPT FAM206A FAM206A BAG4 BAG4 SLAIN1 SLAIN1 ENSGALP00000073167 ENSGALP00000073167 NCKAP1 NCKAP1 CCLL4 CCLL4 PFN2 PFN2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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LOC112530485Uncharacterized protein. (326 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (119 aa)
TBCDTubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] (1203 aa)
CAMSAP1Calmodulin regulated spectrin associated protein 1. (1623 aa)
BBS4TPR_REGION domain-containing protein. (532 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
TMOD1Uncharacterized protein. (359 aa)
CAMSAP2Calmodulin regulated spectrin associated protein family member 2. (1490 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (853 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2660 aa)
MYL1Myosin light chain 1, skeletal muscle isoform. (192 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
BAIAP2L1Uncharacterized protein. (506 aa)
FBLIM1Filamin binding LIM protein 1. (338 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1711 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (240 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
LOC419677Uncharacterized protein. (324 aa)
CAPZBF-actin-capping protein subunit beta isoforms 1 and 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization. (277 aa)
TRAF3IP1TRAF3 interacting protein 1. (665 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
TMOD3Uncharacterized protein. (352 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. (827 aa)
VILLVillin like. (860 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
MAPRE1Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Belongs to the MAPRE family. (263 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. (174 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1189 aa)
PAK3Non-specific serine/threonine protein kinase. (543 aa)
NAPBUncharacterized protein. (296 aa)
HRGUncharacterized protein. (1078 aa)
LMOD2Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family. (552 aa)
FERMT1Fermitin family member 1. (677 aa)
MKKSUncharacterized protein. (570 aa)
PFN3Profilin; Belongs to the profilin family. (134 aa)
ZNF827Zinc finger protein 827. (1335 aa)
KANK1ANK_REP_REGION domain-containing protein. (1344 aa)
CXCL13L2Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (100 aa)
EIF2AK2Uncharacterized protein. (550 aa)
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (730 aa)
EVLWH1 domain-containing protein. (418 aa)
WARS1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (473 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
EP300E1A binding protein p300. (2450 aa)
BAIAP2L2BAI1 associated protein 2 like 2. (489 aa)
LATS1Large tumor suppressor kinase 1. (1137 aa)
TUBB2BTubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
RDXRadixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. (583 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (290 aa)
SNX9Sorting nexin. (600 aa)
CDT1Chromatin licensing and DNA replication factor 1. (745 aa)
ARHGAP28Rho GTPase activating protein 28. (490 aa)
CLUL1Clusterin; Belongs to the clusterin family. (461 aa)
RIOK3Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (516 aa)
IMPACTImpact RWD domain protein. (320 aa)
RASA1Uncharacterized protein. (1120 aa)
ADD1Aldolase_II domain-containing protein. (736 aa)
TRAPPC12Trafficking protein particle complex 12. (790 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
DNAJC15J domain-containing protein. (148 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
ARHGEF5Uncharacterized protein. (1733 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
COTL1ADF actin binding protein. (142 aa)
LMOD3Leiomodin 3. (524 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
SVIPUncharacterized protein. (80 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (411 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1435 aa)
SSH2Slingshot protein phosphatase 2. (1395 aa)
ANKRA2ANK_REP_REGION domain-containing protein. (313 aa)
DRG1OBG-type G domain-containing protein. (367 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
CDC42EP4CDC42 effector protein 4. (302 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
AIDAUncharacterized protein. (306 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
HSPB1Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization; Belongs to the small heat shock protein (HSP20) family. (194 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
TMEM130Transmembrane protein 130. (425 aa)
KANK3KN motif and ankyrin repeat domains 3. (1168 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
LMOD1Leiomodin 1. (624 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa)
AKAIN1AKAP7_RIRII_bdg domain-containing protein. (68 aa)
BMFUncharacterized protein. (200 aa)
ANKRD27Uncharacterized protein. (1087 aa)
TWF1Uncharacterized protein. (491 aa)
NAPANSF attachment protein alpha. (313 aa)
CDH17Uncharacterized protein. (835 aa)
NLRC3NLR family CARD domain containing 3. (1095 aa)
SLIT2Uncharacterized protein. (1533 aa)
FAF1Fas associated factor 1. (650 aa)
MSNMoesin. (580 aa)
TMSB15BThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
SENP6SUMO specific peptidase 6. (1148 aa)
BAIAP2BAI1 associated protein 2. (573 aa)
PMEPA1Uncharacterized protein. (286 aa)
PINK1PTEN induced kinase 1. (364 aa)
TPPPTubulin polymerization promoting protein. (219 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
CDC42EP1CDC42 effector protein 1. (388 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1846 aa)
NUMA1Uncharacterized protein. (2226 aa)
LOC100859468Uncharacterized protein. (657 aa)
CAPGCapping actin protein, gelsolin like. (327 aa)
FAM49AProtein FAM49A; Belongs to the FAM49 family. (356 aa)
SMAD6Mothers against decapentaplegic homolog 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling, preventing NF-kappa-B activation, and BMP-SMAD1 signaling pathway. Binds to regulatory elements in target promoter regions (By similarity). (431 aa)
ENSGALP00000050074Uncharacterized protein. (685 aa)
FLIIUncharacterized protein. (1228 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa)
HIP1RUncharacterized protein. (977 aa)
ADD2Adducin 2. (775 aa)
ENSGALP00000051793Uncharacterized protein. (360 aa)
CXCL13L3Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1081 aa)
SOSTSclerostin. (213 aa)
CDK5RAP2Uncharacterized protein. (751 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (385 aa)
TBX20T-box transcription factor TBX20; Acts as a transcriptional regulator involved in heart developmental processes. (440 aa)
C15orf62Chromosome 15 open reading frame 62. (176 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2362 aa)
C7orf73Uncharacterized protein. (49 aa)
HCLS1SH3 domain-containing protein. (515 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (833 aa)
METUncharacterized protein. (1382 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1049 aa)
HJURPUncharacterized protein. (772 aa)
PRUNE1Prune exopolyphosphatase 1. (521 aa)
LGALS3Galectin. (258 aa)
BAK1Uncharacterized protein. (216 aa)
SAR1BUncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
ENSGALP00000055818Uncharacterized protein. (734 aa)
BBS10Uncharacterized protein. (317 aa)
STMN2Stathmin-2; Is a key regulator of neurite extension through regulation of microtubule instabilily. (179 aa)
ARHGAP18Rho GTPase activating protein 18. (652 aa)
CARMIL1Uncharacterized protein. (1429 aa)
MTPNMyotrophin; Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity); Belongs to the myotrophin family. (118 aa)
FERMT2Fermitin family member 2. (720 aa)
LOC421441PH domain-containing protein. (1734 aa)
NCKAP1LUncharacterized protein. (1130 aa)
FCHSD2FCH and double SH3 domains 2. (1105 aa)
NOP53NOP53 ribosome biogenesis factor. (598 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line. (286 aa)
CAPZA1F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. (286 aa)
TMOD2Tropomodulin 2. (351 aa)
TENM1Teneurin C-terminal-associated peptide; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). [Ten-1 intracellular domain]: Induces gene transcription activation; Belongs to the tenascin family. Teneurin subfamily. (2713 aa)
DBN1Drebrin; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in synaptic plasticity (By similarity). (652 aa)
TOGARAM1TOG array regulator of axonemal microtubules 1. (1580 aa)
HSF1Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] (343 aa)
VIL1Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa)
FESFES proto-oncogene, tyrosine kinase. (885 aa)
DHX33Uncharacterized protein. (143 aa)
ENSGALP00000060289Uncharacterized protein. (217 aa)
ENSGALP00000060643Uncharacterized protein. (116 aa)
STMN1Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity). (172 aa)
ENSGALP00000061073PH_9 domain-containing protein. (674 aa)
TIRAPTIR domain-containing protein. (231 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa)
CXCL13Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
PTGER4Prostaglandin E2 receptor subtype 4; Belongs to the G-protein coupled receptor 1 family. (475 aa)
ENSGALP00000065294Uncharacterized protein. (1324 aa)
LOC107049673Glucosylceramidase. (298 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
PLEKUncharacterized protein. (353 aa)
PDE4DIPNBPF domain-containing protein. (932 aa)
JAM3Junctional adhesion molecule 3. (458 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
DMTNAbLIM_anchor domain-containing protein. (687 aa)
SPTBN4LCalponin-homology (CH) domain-containing protein. (862 aa)
DBNLADF-H domain-containing protein. (124 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1; Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization. (2497 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). (674 aa)
STXBP6V-SNARE coiled-coil homology domain-containing protein. (210 aa)
FNIP2Folliculin interacting protein 2. (1165 aa)
ENSGALP00000066829Uncharacterized protein. (105 aa)
NCK1Cytoplasmic protein. (380 aa)
CLIP1CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. (1444 aa)
TTBK1Protein kinase domain-containing protein. (1419 aa)
ENSGALP00000067665Uncharacterized protein. (423 aa)
INPP5J-2SKICH domain-containing protein. (338 aa)
ICE1Uncharacterized protein. (1919 aa)
TPPP2Tubulin polymerization promoting protein family member 2. (174 aa)
SLAIN2SLAIN motif family member 2. (597 aa)
CCL19C-C motif chemokine. (108 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ENSGALP00000068509CKK domain-containing protein. (392 aa)
LOC101752211Uncharacterized protein. (95 aa)
ENSGALP00000069115Calponin-homology (CH) domain-containing protein. (192 aa)
SPTBN5Uncharacterized protein. (3926 aa)
HAX1HCLS1 associated protein X-1. (315 aa)
ELNElastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. (811 aa)
ARHGAP40Rho-GAP domain-containing protein. (868 aa)
SVILSupervillin. (2303 aa)
LOC107056280Uncharacterized protein. (466 aa)
FAM178BUncharacterized protein. (653 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (176 aa)
SPTBN2Uncharacterized protein. (708 aa)
SPIDRScaffold protein involved in DNA repair. (937 aa)
SLF1SMC5-SMC6 complex localization factor 1. (981 aa)
ADD3Aldolase_II domain-containing protein. (742 aa)
LOC107050229Glucosylceramidase. (538 aa)
MECP2Methyl-CpG binding protein 2. (208 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (178 aa)
ENSGALP00000070586Uncharacterized protein. (1264 aa)
BCL2L11BCL2 like 11. (179 aa)
CTTNSrc substrate protein p85; Contributes to the organization of the actin cytoskeleton and cell shape (By similarity). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones, and may play a role in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cel [...] (516 aa)
CKAP5Uncharacterized protein. (2073 aa)
ENSGALP00000071066FERM_M domain-containing protein. (543 aa)
CRACDKIAA1211. (1561 aa)
USP50UCH domain-containing protein. (115 aa)
ENSGALP00000071309Calponin-homology (CH) domain-containing protein. (153 aa)
KANK4KN motif and ankyrin repeat domains 4. (1010 aa)
LOC107050733Med25 domain-containing protein. (143 aa)
TMSB4YThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
TMOD4Uncharacterized protein. (570 aa)
KIF9Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (812 aa)
SLC39A12Solute carrier family 39 member 12. (702 aa)
RNF4RING-type domain-containing protein. (194 aa)
FCHSD1FCH and double SH3 domains 1. (788 aa)
WNT1Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. Developmental protein that promotes cell proliferation in the developing spinal cord. Has a role in osteoblast function, bone development and bone homeostasis (By similarity). (550 aa)
CDC42EP3CDC42 effector protein 3. (253 aa)
SKAP1Src kinase associated phosphoprotein 1. (355 aa)
ENSGALP00000072279Cnn_1N domain-containing protein. (161 aa)
CTNNBIP1ICAT domain-containing protein. (81 aa)
MAP2Microtubule-associated protein. (1955 aa)
ENSGALP00000072464Uncharacterized protein. (549 aa)
MAPTMicrotubule-associated protein. (788 aa)
FAM206AProtein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons; Belongs to the ABITRAM family. (363 aa)
BAG4BCL2 associated athanogene 4. (364 aa)
SLAIN1SLAIN motif family member 1. (702 aa)
ENSGALP00000073167Cnn_1N domain-containing protein. (48 aa)
NCKAP1NCK associated protein 1. (1134 aa)
CCLL4C-C motif chemokine. (95 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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