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LRRC38 LRRC38 GPER1 GPER1 P2RX4 P2RX4 P2RX7 P2RX7 PLCG1 PLCG1 NKX2-5 NKX2-5 TRPC1 TRPC1 LOC416197 LOC416197 STC1 STC1 CEBPB CEBPB ATP1B3 ATP1B3 AMIGO1 AMIGO1 PTGES PTGES PLA2G6 PLA2G6 EDN1 EDN1 STIM2 STIM2 F1NA95_CHICK F1NA95_CHICK WFS1 WFS1 HTT HTT ARC ARC ACE2 ACE2 APLNR APLNR PLA2G10L PLA2G10L COX17 COX17 CHP1 CHP1 PLA2R1 PLA2R1 ENSGALP00000071809 ENSGALP00000071809 LOC112530976 LOC112530976 GCG GCG PLA2G10 PLA2G10 P2RX1 P2RX1 ATF4 ATF4 THY1 THY1 TNFSF11 TNFSF11 CX3CL1 CX3CL1 TMEM27 TMEM27 CACNG4 CACNG4 CAV1 CAV1 STIM1 STIM1 ENSGALP00000045329 ENSGALP00000045329 PINK1 PINK1 SLC6A1 SLC6A1 PKD2 PKD2 CASK CASK ANXA2P2 ANXA2P2 STAC STAC RAMP3 RAMP3 CFTR CFTR SYT4 SYT4 RNF207 RNF207 CACNB4 CACNB4 DRD4 DRD4 PLCG2 PLCG2 NPSR1 NPSR1 ATPSCKMT ATPSCKMT WNK2 WNK2 CAPN3 CAPN3 R3HDM1 R3HDM1 LOC107049024 LOC107049024 LGALS3 LGALS3 BAK1 BAK1 KCNE5 KCNE5 IFNGR2 IFNGR2 SLC17A8 SLC17A8 HOMER1 HOMER1 WNK4 WNK4 CACNG2 CACNG2 NDUFA4 NDUFA4 F2RL3 F2RL3 LRRC26 LRRC26 TNFRSF11A TNFRSF11A CNTD1 CNTD1 COA8 COA8 ENSGALP00000065128 ENSGALP00000065128 GPR25 GPR25 UCN UCN KCNQ1 KCNQ1 ENSGALP00000071543 ENSGALP00000071543 R3HDM2 R3HDM2 ENSGALP00000066996 ENSGALP00000066996 PIRT PIRT SLC9A1 SLC9A1 PDZK1 PDZK1 ADCYAP1R1 ADCYAP1R1 ENSGALP00000067557 ENSGALP00000067557 AKAP7 AKAP7 SCN3B SCN3B ORAI1 ORAI1 CDK5 CDK5 WNK1 WNK1 PSEN1 PSEN1 STAC3 STAC3 LOC776273 LOC776273 TESC TESC F2 F2 CAV3 CAV3 TRH TRH SRI SRI ANO6 ANO6 AMIGO2 AMIGO2 AKAP6 AKAP6 EDNRA EDNRA SNX4 SNX4 PDGFB PDGFB RAB3GAP1 RAB3GAP1 DRD2 DRD2 SCN4B SCN4B FHL1 FHL1 ABCC8 ABCC8 VMP1 VMP1 PLA2G4A PLA2G4A TRPV2 TRPV2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRC38Leucine rich repeat containing 38. (293 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (385 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1277 aa)
NKX2-5Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1 isoform alpha; Belongs to the transient receptor (TC 1.A.4) family. (781 aa)
LOC416197G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (532 aa)
STC1Stanniocalcin 1. (247 aa)
CEBPBCCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...] (328 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known; Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (492 aa)
PTGESProstaglandin E synthase. (146 aa)
PLA2G6Uncharacterized protein. (796 aa)
EDN1Endothelin 1. (194 aa)
STIM2Stromal interaction molecule 2. (740 aa)
F1NA95_CHICKAKAP7_NLS domain-containing protein. (256 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
HTTHuntingtin. (3095 aa)
ARCActivity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis- dependent forms [...] (404 aa)
ACE2Angiotensin-converting enzyme. (808 aa)
APLNRApelin receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PLA2G10LPhospholipase A(2). (158 aa)
COX17Uncharacterized protein. (67 aa)
CHP1Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa)
PLA2R1Uncharacterized protein. (1459 aa)
ENSGALP00000071809SH2 domain-containing protein. (217 aa)
LOC112530976FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (77 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
PLA2G10Phospholipase A(2). (155 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (392 aa)
ATF4ATF4. (354 aa)
THY1Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
CX3CL1SCY domain-containing protein. (496 aa)
TMEM27Collectrin domain-containing protein. (226 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
STIM1SAM domain-containing protein. (742 aa)
ENSGALP00000045329Asp-B-Hydro_N domain-containing protein. (161 aa)
PINK1PTEN induced kinase 1. (364 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (598 aa)
PKD2Uncharacterized protein. (881 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (944 aa)
ANXA2P2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa)
STACSH3 and cysteine rich domain. (402 aa)
RAMP3Receptor activity modifying protein 3. (156 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
SYT4Synaptotagmin 4. (425 aa)
RNF207Ring finger protein 207. (658 aa)
CACNB4SH3 domain-containing protein. (480 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (378 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (373 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (234 aa)
WNK2WNK lysine deficient protein kinase 2. (2294 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
R3HDM1R3H domain containing 1. (1051 aa)
LOC107049024Epidermal differentiation protein. (316 aa)
LGALS3Galectin. (258 aa)
BAK1Uncharacterized protein. (216 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (103 aa)
IFNGR2Uncharacterized protein. (334 aa)
SLC17A8MFS domain-containing protein. (587 aa)
HOMER1Homer scaffold protein 1. (358 aa)
WNK4Protein kinase domain-containing protein. (440 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
NDUFA4Uncharacterized protein. (96 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (386 aa)
LRRC26Uncharacterized protein. (320 aa)
TNFRSF11ATNF receptor superfamily member 11a. (656 aa)
CNTD1Cyclin N-terminal domain containing 1. (254 aa)
COA8Cytochrome c oxidase assembly factor 8. (185 aa)
ENSGALP00000065128SH2 domain-containing protein. (126 aa)
GPR25Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. (365 aa)
UCNUrocortin. (100 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
ENSGALP00000071543Uncharacterized protein. (439 aa)
R3HDM2Uncharacterized protein. (1218 aa)
ENSGALP00000066996Uncharacterized protein. (110 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (141 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa)
PDZK1PDZ domain containing 1. (548 aa)
ADCYAP1R1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (499 aa)
ENSGALP00000067557Uncharacterized protein. (239 aa)
AKAP7A-kinase anchoring protein 7. (468 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (303 aa)
ORAI1Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores; Belongs to the Orai family. (226 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
WNK1WNK lysine deficient protein kinase 1. (2662 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
STAC3SH3 and cysteine rich domain 3. (363 aa)
LOC7762731-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
TESCCalcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity). (214 aa)
F2Uncharacterized protein; Belongs to the peptidase S1 family. (644 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
SRIUncharacterized protein. (297 aa)
ANO6Anoctamin. (912 aa)
AMIGO2Ig-like domain-containing protein. (521 aa)
AKAP6A-kinase anchoring protein 6. (2342 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
SNX4Sorting nexin 4. (435 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1014 aa)
DRD2Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (182 aa)
FHL1Four and a half LIM domains 1. (297 aa)
ABCC8ATP binding cassette subfamily C member 8. (1595 aa)
VMP1Vacuole membrane protein 1. (406 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (789 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (785 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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