(17 nodes) Leukocyte degranulation network (Gallus gallus)

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	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (209 aa)
	PTGDR	Prostaglandin D2 receptor. (362 aa)
	LYN	Tyrosine-protein kinase. (491 aa)
	LAT2	Linker for activation of T-cells family member 2; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2. (198 aa)
	CPLX2	Uncharacterized protein. (134 aa)
	VAMP7	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family. (220 aa)
	ADORA2B	Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (340 aa)
	SEC11A	Signal peptidase complex catalytic subunit SEC11. (179 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
	PTGDS	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (185 aa)
	SEC11C	Signal peptidase complex catalytic subunit SEC11. (177 aa)
	RASGRP1	RAS guanyl releasing protein 1. (480 aa)
	STXBP3	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
	ENSGALP00000066581	Uncharacterized protein. (532 aa)
	GRP	Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
	RAB44	Uncharacterized protein. (1276 aa)
	CLNK	SH2 domain-containing protein. (175 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2B	PTGDR	ENSGALP00000027991	ENSGALP00000048744	Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin D2 receptor.	0.437
CPLX2	ENSGALP00000066581	ENSGALP00000042773	ENSGALP00000066581	Uncharacterized protein.	Uncharacterized protein.	0.414
CPLX2	SNAP23	ENSGALP00000042773	ENSGALP00000014793	Uncharacterized protein.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.717
CPLX2	VAMP7	ENSGALP00000042773	ENSGALP00000031702	Uncharacterized protein.	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family.	0.545
ENSGALP00000066581	CPLX2	ENSGALP00000066581	ENSGALP00000042773	Uncharacterized protein.	Uncharacterized protein.	0.414
ENSGALP00000066581	VAMP7	ENSGALP00000066581	ENSGALP00000031702	Uncharacterized protein.	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family.	0.553
KIT	LYN	ENSGALP00000051217	ENSGALP00000047115	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...]	Tyrosine-protein kinase.	0.711
LYN	KIT	ENSGALP00000047115	ENSGALP00000051217	Tyrosine-protein kinase.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...]	0.711
PTGDR	ADORA2B	ENSGALP00000048744	ENSGALP00000027991	Prostaglandin D2 receptor.	Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.	0.437
PTGDR	PTGDS	ENSGALP00000048744	ENSGALP00000052720	Prostaglandin D2 receptor.	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	0.529
PTGDS	PTGDR	ENSGALP00000052720	ENSGALP00000048744	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Prostaglandin D2 receptor.	0.529
SEC11A	SEC11C	ENSGALP00000049552	ENSGALP00000055426	Signal peptidase complex catalytic subunit SEC11.	Signal peptidase complex catalytic subunit SEC11.	0.901
SEC11C	SEC11A	ENSGALP00000055426	ENSGALP00000049552	Signal peptidase complex catalytic subunit SEC11.	Signal peptidase complex catalytic subunit SEC11.	0.901
SNAP23	CPLX2	ENSGALP00000014793	ENSGALP00000042773	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein.	0.717
SNAP23	STXBP3	ENSGALP00000014793	ENSGALP00000065190	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.707
SNAP23	VAMP7	ENSGALP00000014793	ENSGALP00000031702	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family.	0.993
STXBP3	SNAP23	ENSGALP00000065190	ENSGALP00000014793	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.707
VAMP7	CPLX2	ENSGALP00000031702	ENSGALP00000042773	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family.	Uncharacterized protein.	0.545
VAMP7	ENSGALP00000066581	ENSGALP00000031702	ENSGALP00000066581	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family.	Uncharacterized protein.	0.553
VAMP7	SNAP23	ENSGALP00000031702	ENSGALP00000014793	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.993