22 items (Gallus gallus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Input:
	GATA3	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
	SKI	Ski oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity). (750 aa)
	NEUROD1	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
	HMGB2	High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antige [...] (207 aa)
	EP300	E1A binding protein p300. (2450 aa)
	TXN	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
	DDRGK1	DDRGK domain containing 1. (221 aa)
	NIBAN2	Niban apoptosis regulator 2. (898 aa)
	ISL1	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
	SIRT2	Deacetylase sirtuin-type domain-containing protein. (485 aa)
	EGF	Uncharacterized protein. (1283 aa)
	CTNNB1	Uncharacterized protein. (781 aa)
	POU4F1	POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
	PITX2	Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (356 aa)
	EDF1	Endothelial differentiation-related factor 1 homolog; Probable transcriptional coactivator. (148 aa)
	GTF2B	General transcription factor IIB. (344 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	MMP9	Uncharacterized protein. (713 aa)
	MYOCD	Phosphatase and actin regulator. (908 aa)
	RB1	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	EGF	ENSGALP00000045406	ENSGALP00000044972	Uncharacterized protein.	Uncharacterized protein.	0.575
CTNNB1	EP300	ENSGALP00000045406	ENSGALP00000019537	Uncharacterized protein.	E1A binding protein p300.	0.941
CTNNB1	MMP9	ENSGALP00000045406	ENSGALP00000068659	Uncharacterized protein.	Uncharacterized protein.	0.513
CTNNB1	SIRT2	ENSGALP00000045406	ENSGALP00000044776	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.533
EGF	CTNNB1	ENSGALP00000044972	ENSGALP00000045406	Uncharacterized protein.	Uncharacterized protein.	0.575
EGF	ISL1	ENSGALP00000044972	ENSGALP00000043151	Uncharacterized protein.	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.404
EGF	MMP9	ENSGALP00000044972	ENSGALP00000068659	Uncharacterized protein.	Uncharacterized protein.	0.722
EGF	NEUROD1	ENSGALP00000044972	ENSGALP00000014468	Uncharacterized protein.	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	0.434
EP300	CTNNB1	ENSGALP00000019537	ENSGALP00000045406	E1A binding protein p300.	Uncharacterized protein.	0.941
EP300	GATA3	ENSGALP00000019537	ENSGALP00000068882	E1A binding protein p300.	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	0.901
EP300	GTF2B	ENSGALP00000019537	ENSGALP00000060224	E1A binding protein p300.	General transcription factor IIB.	0.669
EP300	MYOCD	ENSGALP00000019537	ENSGALP00000069052	E1A binding protein p300.	Phosphatase and actin regulator.	0.424
EP300	SIRT2	ENSGALP00000019537	ENSGALP00000044776	E1A binding protein p300.	Deacetylase sirtuin-type domain-containing protein.	0.510
GATA3	EP300	ENSGALP00000068882	ENSGALP00000019537	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	E1A binding protein p300.	0.901
GATA3	ISL1	ENSGALP00000068882	ENSGALP00000043151	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.712
GATA3	NEUROD1	ENSGALP00000068882	ENSGALP00000014468	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	0.538
GATA3	POU4F1	ENSGALP00000068882	ENSGALP00000046501	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...]	0.428
GTF2B	EP300	ENSGALP00000060224	ENSGALP00000019537	General transcription factor IIB.	E1A binding protein p300.	0.669
ISL1	EGF	ENSGALP00000043151	ENSGALP00000044972	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	Uncharacterized protein.	0.404
ISL1	GATA3	ENSGALP00000043151	ENSGALP00000068882	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	0.712