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| | PHOX2B | Paired like homeobox 2B. (292 aa) |
| | FGF8 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa) |
| | SIX4 | SIX homeobox 4. (776 aa) |
| | IFT88 | Intraflagellar transport 88. (817 aa) |
| | GABRA5 | Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (373 aa) |
| | LRRC1 | Leucine rich repeat containing 1. (797 aa) |
| | MYO6 | Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-su [...] (1276 aa) |
| | TTC39C | Tetratricopeptide repeat domain 39C. (576 aa) |
| | CYTL1 | Cytokine like 1. (132 aa) |
| | MSX1 | Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa) |
| | E1C1Y1_CHICK | Uncharacterized protein. (351 aa) |
| | AHI1 | Abelson helper integration site 1. (1242 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1300 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa) |
| | EDN1 | Endothelin 1. (194 aa) |
| | ROR1 | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (896 aa) |
| | DFNA5 | Uncharacterized protein. (505 aa) |
| | PTPRQ | Protein tyrosine phosphatase receptor type Q. (2308 aa) |
| | TRIP11 | Thyroid hormone receptor interactor 11. (1980 aa) |
| | TTC8 | Tetratricopeptide repeat domain 8. (567 aa) |
| | TSHR | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa) |
| | CLRN1 | Clarin 1. (232 aa) |
| | LGR5 | Leucine rich repeat containing G protein-coupled receptor 5. (909 aa) |
| | EDNRA | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa) |
| | PROX1 | Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa) |
| | LRIG3 | Uncharacterized protein. (1099 aa) |
| | KCNK2 | Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa) |
| | USH2A | Usherin. (5190 aa) |
| | MYO3B | Myosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1287 aa) |
| | DLX5 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa) |
| | NEUROD1 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa) |
| | WDPCP | WD repeat containing planar cell polarity effector. (807 aa) |
| | SLC26A5 | Prestin. (742 aa) |
| | C1QTNF5 | C1q and TNF related 5. (585 aa) |
| | CXCL14 | Jun-suppressed chemokine. (98 aa) |
| | USH1C | USH1 protein network component harmonin. (556 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (929 aa) |
| | PAFAH1B1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa) |
| | CCM2 | PID domain-containing protein. (453 aa) |
| | ADAM10 | Uncharacterized protein. (749 aa) |
| | LOC427439 | Nipped-B protein. (2783 aa) |
| | OCM | Parvalbumin, thymic CPV3; Binds two calcium ions. (109 aa) |
| | PRRX1 | Paired mesoderm homeobox protein 1; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face. (245 aa) |
| | FRZB | Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (315 aa) |
| | PCDH15 | Protocadherin-15; Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity). (2192 aa) |
| | LHX3 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa) |
| | STRA6 | Uncharacterized protein. (671 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (395 aa) |
| | ENSGALP00000073923 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (324 aa) |
| | PDZD7 | PDZ domain-containing protein. (413 aa) |
| | SLC4A7 | Anion exchange protein. (1243 aa) |
| | OTX1 | Orthodenticle homeobox 1. (335 aa) |
| | ATG4B | Cysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE). Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). (393 aa) |
| | OSR1 | Uncharacterized protein. (260 aa) |
| | RDH10 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (446 aa) |
| | LOC107050371 | Uncharacterized protein. (1015 aa) |
| | WHRN | Whirlin. (926 aa) |
| | KCNQ1 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa) |
| | ADGRV1 | Uncharacterized protein. (4788 aa) |
| | BCL2L11 | BCL2 like 11. (179 aa) |
| | DLX6 | Homeobox domain-containing protein. (283 aa) |
| | ENSGALP00000069955 | Uncharacterized protein. (496 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (314 aa) |
| | RPGRIP1L | RPGRIP1 like. (1273 aa) |
| | GATA3 | GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa) |
| | ENSGALP00000068651 | Uncharacterized protein. (150 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa) |
| | RARG | Retinoic acid receptor gamma. (490 aa) |
| | REST | Uncharacterized protein. (339 aa) |
| | ENSGALP00000066624 | Uncharacterized protein. (187 aa) |
| | TPRN | Phostensin domain-containing protein. (125 aa) |
| | NKX3-2 | Homeobox domain-containing protein. (275 aa) |
| | GRXCR2 | Glutaredoxin and cysteine rich domain containing 2. (132 aa) |
| | EEF1E1 | Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking (By similarity); Belongs to the BLOC1S5 family. (221 aa) |
| | MKS1 | MKS transition zone complex subunit 1. (562 aa) |
| | IFT20 | Intraflagellar transport 20. (132 aa) |
| | C1QB | Complement C1q B chain. (244 aa) |
| | SLITRK6 | SLIT and NTRK like family member 6. (840 aa) |
| | GSC | Homeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa) |
| | WDR19 | WD_REPEATS_REGION domain-containing protein. (470 aa) |
| | LHX4 | LIM homeobox 4. (533 aa) |
| | CECR2 | Bromo domain-containing protein. (1531 aa) |
| | CEBPD | CCAAT enhancer binding protein delta. (302 aa) |
| | NBL1 | Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor. (194 aa) |
| | TBX2 | T-box transcription factor 2. (693 aa) |
| | WNT3A | Protein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa) |
| | CHD7 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa) |
| | SLC17A8 | MFS domain-containing protein. (587 aa) |
| | MYO3A | Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1632 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | SOBP | Sine oculis-binding protein homolog; Implicated in development of the cochlea. (873 aa) |
| | FOXG1 | Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa) |
| | ZIC1 | Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). (444 aa) |
| | GBX2 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa) |
| | LOC427025 | Nipped-B protein. (2769 aa) |
| | EYA1 | Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa) |
| | FREM2 | FRAS1 related extracellular matrix 2. (3168 aa) |
| | BMPER | Crossveinless-2. (678 aa) |
| | SEC24B | Uncharacterized protein. (1234 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa) |
| | LRTOMT | Uncharacterized protein. (259 aa) |
| | OTOP1 | Otopetrin 1. (609 aa) |
| | SOX21 | Transcription factor SOX-21; Acts as a negative regulator of transcription. (280 aa) |
| | ENSGALP00000048186 | Uncharacterized protein. (528 aa) |
| | OSR2 | Uncharacterized protein. (412 aa) |
| | ENSGALP00000047771 | Uncharacterized protein. (240 aa) |
| | CHD9 | Chromodomain helicase DNA binding protein 9. (2820 aa) |
| | SIX1 | Sine oculis-related homeobox 1 homolog. (282 aa) |
| | OC90 | Otoconin. (524 aa) |
| | USH1G | USH1 protein network component sans. (457 aa) |
| | SOX2 | Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa) |
| | TBX3 | T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa) |
| | NAGLU | N-acetyl-alpha-glucosaminidase. (751 aa) |
| | FZD3 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa) |
| | SIX2 | Sine oculis-related homeobox 2 homolog. (287 aa) |
| | MPV17 | Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (256 aa) |
| | NTN1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa) |
| | PDZD7-2 | Uncharacterized protein. (548 aa) |
| | DFNB59 | Gasdermin domain-containing protein. (273 aa) |
| | SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) |
| | RARB | Retinoic acid receptor beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for limb and craniofacial development. (455 aa) |
| | GRXCR1 | Glutaredoxin and cysteine rich domain containing 1. (293 aa) |
| | LRIG1 | Leucine rich repeats and immunoglobulin like domains 1. (1206 aa) |
