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| | CHMP7 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family. (448 aa) |
| | CDC27 | Uncharacterized protein. (833 aa) |
| | PPP6C | Serine/threonine-protein phosphatase. (563 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | LZTS1 | Leucine zipper tumor suppressor 1. (604 aa) |
| | CHMP4B | Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (227 aa) |
| | E2F1 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa) |
| | FBXL8 | F-box domain-containing protein. (379 aa) |
| | CCND3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa) |
| | SKP2 | F-box domain-containing protein. (520 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (565 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa) |
| | CCNE1 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (407 aa) |
| | FBXL15 | F-box and leucine rich repeat protein 15. (299 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | USH1C | USH1 protein network component harmonin. (556 aa) |
| | KDM8 | Lysine demethylase 8. (401 aa) |
| | CCNJ | Cyclin J; Belongs to the cyclin family. (383 aa) |
| | MASTL | Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...] (889 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) |
| | CDC23 | Cell division cycle 23. (595 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2290 aa) |
| | CDK15 | Cyclin dependent kinase 15. (253 aa) |
| | CCNG2 | Cyclin G2. (259 aa) |
| | SPAST | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (613 aa) |
| | CDK17 | Cyclin dependent kinase 17. (536 aa) |
| | CCNI | Cyclin I; Belongs to the cyclin family. (384 aa) |
| | CCNA2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa) |
| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1137 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | FOXM1 | Fork-head domain-containing protein. (795 aa) |
| | ZPR1 | ZPR1 zinc finger. (447 aa) |
| | TPD52L1 | Tumor protein D53 homolog. (210 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (912 aa) |
| | BACH1 | BTB domain and CNC homolog 1. (675 aa) |
| | KLF11 | Uncharacterized protein. (530 aa) |
| | CDC16 | TPR_REGION domain-containing protein. (623 aa) |
| | TFDP1 | Transcription factor. (411 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (406 aa) |
| | CCND2 | G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa) |
| | SPDYA | Speedy/RINGO cell cycle regulator family member A. (324 aa) |
| | CDK3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (309 aa) |
| | TRIM71 | E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development. Belongs to the TRIM/RBCC family. (877 aa) |
| | SIRT7 | Deacetylase sirtuin-type domain-containing protein. (399 aa) |
| | E2F6 | E2F_TDP domain-containing protein. (252 aa) |
| | APP | BPTI/Kunitz inhibitor domain-containing protein. (751 aa) |
| | E2F3 | E2F transcription factor 3. (341 aa) |
| | USP37 | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity); Belongs to the peptidase C19 family. (988 aa) |
| | ARPP19 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity); Belongs to the endosulfine family. (112 aa) |
| | CCNI2 | Cyclin I family member 2; Belongs to the cyclin family. (259 aa) |
| | GPR132 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (373 aa) |
| | CCNO | Cyclin O; Belongs to the cyclin family. (338 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | CCNE2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | HINFP | Histone H4 transcription factor. (546 aa) |
| | PPM1D | Protein phosphatase, Mg2+/Mn2+ dependent 1D. (590 aa) |
| | ACVR1 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). (524 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] (451 aa) |
| | RCC1 | Regulator of chromosome condensation 1. (417 aa) |
| | E2F7 | E2F transcription factor 7. (923 aa) |
| | CLASP1 | Cytoplasmic linker associated protein 1. (1499 aa) |
| | CHEK2 | Uncharacterized protein. (524 aa) |
| | CCNF | Cyclin F; Belongs to the cyclin family. (750 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa) |
| | CHMP2A | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | NASP | Nuclear autoantigenic sperm protein. (456 aa) |
| | ENSA | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). (117 aa) |
| | KHDRBS1 | KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates [...] (442 aa) |
| | FBXL7 | F-box and leucine rich repeat protein 7. (491 aa) |
| | CACUL1 | Cullin domain-containing protein; Belongs to the cullin family. (377 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1086 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | CDC25A | Rhodanese domain-containing protein. (526 aa) |
| | CCNB3 | G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. (403 aa) |
| | RPL24 | TRASH domain-containing protein. (156 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | LOC112530990 | Uncharacterized protein. (205 aa) |
| | CDK18 | Cyclin dependent kinase 18. (615 aa) |
| | CCNJL | Cyclin J like; Belongs to the cyclin family. (402 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1948 aa) |
| | BRSK1 | Protein kinase domain-containing protein. (802 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (268 aa) |
| | CIT | Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2068 aa) |
| | CDC25B | Cell division cycle 25B. (555 aa) |
| | CLASP2 | Uncharacterized protein. (1506 aa) |
| | FBXL22 | F-box and leucine rich repeat protein 22. (226 aa) |
| | FBXL3 | F-box and leucine rich repeat protein 3. (433 aa) |
| | CDK5 | Protein kinase domain-containing protein. (522 aa) |
| | LOC107050650 | Protein kinase domain-containing protein. (153 aa) |
| | CDK14 | Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (469 aa) |
| | CTDP1 | CTD phosphatase subunit 1. (1047 aa) |
| | FBXL12 | Uncharacterized protein. (471 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1125 aa) |
