STRINGSTRING
HOOK1 HOOK1 PIK3C3 PIK3C3 KIF16B KIF16B EMP2 EMP2 RAB7A RAB7A WDR81 WDR81 AKTIP AKTIP STX8 STX8 PIK3R4 PIK3R4 SNX16 SNX16 ANKRD27 ANKRD27 HOOK3 HOOK3 ATG14 ATG14 WDR91 WDR91 BECN1 BECN1 RILP RILP SNF8 SNF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOOK1Protein Hook homolog 1; May function to promote vesicle trafficking and/or fusion. (718 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
KIF16BKinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2059 aa)
EMP2Epithelial membrane protein 2. (167 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
WDR81WD repeat domain 81. (1946 aa)
AKTIPAKT-interacting protein; May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity); Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. (351 aa)
STX8t-SNARE coiled-coil homology domain-containing protein. (273 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1426 aa)
SNX16PX domain-containing protein. (347 aa)
ANKRD27Uncharacterized protein. (1087 aa)
HOOK3Hook microtubule tethering protein 3. (713 aa)
ATG14Autophagy related 14. (492 aa)
WDR91WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa)
BECN1Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa)
RILPRab interacting lysosomal protein. (400 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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