STRINGSTRING
SDF4 SDF4 SYT6 SYT6 UNC13B UNC13B P2RX7 P2RX7 SYT12 SYT12 SYT9 SYT9 ERC2 ERC2 SYT8 SYT8 SYT13 SYT13 SNAP25 SNAP25 STEAP2 STEAP2 SNAP23 SNAP23 RAB11FIP2 RAB11FIP2 STX11 STX11 CRHBP CRHBP SYK SYK CPLX1 CPLX1 RIMS1 RIMS1 LRRC1 LRRC1 BLK BLK ADORA2B ADORA2B VAMP7 VAMP7 RAB31 RAB31 VAMP3 VAMP3 SNAPIN SNAPIN CPLX3 CPLX3 SYT1 SYT1 CPLX2 CPLX2 SYNGR2 SYNGR2 SYNJ1 SYNJ1 UNC13A UNC13A STX1A STX1A STX2 STX2 UNC13C UNC13C CADPS CADPS RAB26 RAB26 RIMS1-2 RIMS1-2 LAT2 LAT2 LYN LYN SYT2 SYT2 SNAP29 SNAP29 PTGDR PTGDR SEC11A SEC11A SYT4 SYT4 KIT KIT CPLX4 CPLX4 PTGDS PTGDS MYH9 MYH9 RAPGEF4 RAPGEF4 SEC11C SEC11C SYT17 SYT17 SYT7 SYT7 SYT15 SYT15 SYT11 SYT11 RASGRP1 RASGRP1 TMEM79 TMEM79 TPH1 TPH1 ENSGALP00000065007 ENSGALP00000065007 STXBP3 STXBP3 RIMS2 RIMS2 UNC13C-2 UNC13C-2 PLEK PLEK DMTN DMTN STX3 STX3 ENSGALP00000066581 ENSGALP00000066581 STX19 STX19 ENSGALP00000068651 ENSGALP00000068651 CDK5 CDK5 TRARG1 TRARG1 SNAP47 SNAP47 PSEN1 PSEN1 SYNGR3 SYNGR3 RIMS3 RIMS3 GRP GRP CADPS2 CADPS2 RAB11FIP1 RAB11FIP1 RAB44 RAB44 SYT10 SYT10 CLNK CLNK RAB11FIP5 RAB11FIP5 ERC1 ERC1 LOC112530958 LOC112530958 ENSGALP00000074167 ENSGALP00000074167
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SDF445 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family. (356 aa)
SYT6Synaptotagmin 6. (414 aa)
UNC13BUnc-13 homolog B. (1574 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
SYT12C2 domain-containing protein. (417 aa)
SYT9Synaptotagmin 9. (528 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (979 aa)
SYT8Synaptotagmin 8. (396 aa)
SYT13C2 domain-containing protein. (430 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family. (206 aa)
STEAP2STEAP2 metalloreductase. (489 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (209 aa)
RAB11FIP2RAB11 family interacting protein 2. (510 aa)
STX11Syntaxin 11. (288 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
CPLX1Complexin 1. (134 aa)
RIMS1C2 domain-containing protein. (261 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
BLKTyrosine-protein kinase. (526 aa)
ADORA2BAdenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (340 aa)
VAMP7Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family. (220 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
CPLX3Uncharacterized protein. (157 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family. (430 aa)
CPLX2Uncharacterized protein. (134 aa)
SYNGR2Synaptogyrin. (225 aa)
SYNJ1Synaptojanin 1. (1536 aa)
UNC13AUncharacterized protein. (1738 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (407 aa)
STX2t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (288 aa)
UNC13CUncharacterized protein. (1097 aa)
CADPSUncharacterized protein. (1322 aa)
RAB26RAB26, member RAS oncogene family. (190 aa)
RIMS1-2PDZ domain-containing protein. (506 aa)
LAT2Linker for activation of T-cells family member 2; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2. (198 aa)
LYNTyrosine-protein kinase. (491 aa)
SYT2Synaptotagmin 2. (490 aa)
SNAP29t-SNARE coiled-coil homology domain-containing protein. (248 aa)
PTGDRProstaglandin D2 receptor. (362 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
SYT4Synaptotagmin 4. (425 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
CPLX4Complexin 4. (130 aa)
PTGDSLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (185 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1026 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (177 aa)
SYT17Synaptotagmin 17. (474 aa)
SYT7Synaptotagmin 7. (403 aa)
SYT15Uncharacterized protein. (416 aa)
SYT11Synaptotagmin 11. (432 aa)
RASGRP1RAS guanyl releasing protein 1. (480 aa)
TMEM79Transmembrane protein 79. (435 aa)
TPH1Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (475 aa)
ENSGALP00000065007Uncharacterized protein. (162 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1495 aa)
UNC13C-2Uncharacterized protein. (411 aa)
PLEKUncharacterized protein. (353 aa)
DMTNAbLIM_anchor domain-containing protein. (687 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (462 aa)
ENSGALP00000066581Uncharacterized protein. (532 aa)
STX19Syntaxin 19; Belongs to the syntaxin family. (291 aa)
ENSGALP00000068651Uncharacterized protein. (150 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (176 aa)
SNAP47Synaptosome associated protein 47. (461 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
SYNGR3MARVEL domain-containing protein. (295 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (377 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
CADPS2Calcium dependent secretion activator 2. (1298 aa)
RAB11FIP1RAB11 family interacting protein 1. (1259 aa)
RAB44Uncharacterized protein. (1276 aa)
SYT10Synaptotagmin 10. (525 aa)
CLNKSH2 domain-containing protein. (175 aa)
RAB11FIP5Uncharacterized protein. (1661 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1121 aa)
LOC112530958Uncharacterized protein. (149 aa)
ENSGALP00000074167Uncharacterized protein. (178 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.